Department of Internal Medicine Intranet

Department of Internal Medicine Research Day

Research Day Schedule:

Tuesday, October 20, 2020

1:00-2:00 pm Keynote Presentation:
From P-Hacking to Pandemics: An Editor’s Journey Toward Scientific Humility

Brahmajee K. Nallamothu, MD, MPH
University of Michigan

2:00-2:15 pm break

2:15-3:15 pm
Research Mentoring Session with Q&A
Dr. Nallamothu

3:15-3:30 pm break

3:30-5:30 pm

3:30

4:00

4:30

5:00

Invited Short Presentations:

Mediating Cardiac Transcription
Chad Grueter, PhD, Cardiovascular Medicine

Mechanisms of Microvascular Dysfunction Following Preeclamptic Pregnancy
Anna Stanhewicz, PhD, Health and Human Physiology

Cell-Specific Aptamer Ligands to Treat Cardiovascular Disease
William Thiel, PhD, Cardiovascular Medicine

Psychological Insights to Improve How We Communicate Information About Chronic and Infectious Diseases
Aaron Scherer, PhD, General Internal Medicine

Wednesday, October 21, 2020

12:00-1:00 pm Research Mentoring Session with Q&A
Dr. Wu

1:00-2:00 pm Keynote Presentation:

Stem Cells and Genomics for Precision Medicine

Joseph Wu, MD, PhD
Stanford University

2:00-2:15 pm break

2:15-4:00 pm
Concurrent Abstract Sessions (schedule of presenters below)

Session I – Cardiovascular Disease
Session II – Diabetes & obesity
Session III – Gene regulation & muscle biology
Session IV – Immunology & lung biology
Session V – Clinical/Outcomes Research 1
Session VI – Clinical/Outcomes Research 2

Concurrent Abstract Sessions:

Session I - Cardiovascular disease -

2:15 pm Vikram Sharma
Comparison of troponin complexes and free fractions in plasma and circulation peripheral blood mononuclear cells in patients with acute myocardial infarction and end stage renal disease

2:25 pm Nathan Lindsey
Endothelial Specific Mitochondrial Calcium Uniporter Deficiency attenuates Radiation-Induced Brain Blood Barrier Leakage.

2:35 pm Chandan Narayan
Generating cardiac-specific ligands using hi-SELEX ("human-iPSC" SELEX)

2:45 pm Jared McLendon
Loss of SORBS2 in Cardiomyocytes Leads to Dilated Left Ventricle Cardiomyopathy in Mice

2:55 pm Gabriel Baccam
Cardioprotection by Klotho through Lipid Rafts

3:05 pm Helena Kenny
Cardiac specific overexpression of transcription factor EB (TFEB) results in cardiac hypertrophy, contractile dysfunction, altered mitochondrial gene profile and premature death

3:15 pm Qian Shi
Novel role of Insulin receptor substrate 2 (IRS-2) in the maintenance of cardiac calcium homeostasis

3:25 pm Rhonda Souvenir
The Absence of Uncoupling Protein -2 in Platelets Attenuates Thrombosis

Session II - Diabetes and obesity -

2:15 pm Joseph Skurski
Loss of iRhom2 Accelerates Fat Gain and Insulin Resistance in Diet-Induced Obesity Despite Reduced Adipose Tissue Inflammation

2:25 pm William Sivitz (Brian D. Fink)
Effect of Mitoquinone on Liver Metabolism and Steatosis in Obese and Diabetic Rats

2:35 pm Gourav Bhardwaj
Loss of Insulin and IGF1 Receptors in Muscle Impairs Complex I Dependent Mitochondrial Bioenergetics and Supercomplex Formation via FoxO Transcription Factors

2:45 pm Sarah H. Bjorkman
ATF4 Expression in BAT is Required for Adaptive Thermogenesis

2:55 pm Yuan Zhang
Sex Differences in the Response of C57BL/6 Mice to Ketogenic Diets

3:05 pm Kristen Rohli
Mapping of the proinsulin interactome reveals systematic changes to proinsulin trafficking in a model of β-cell dysfunction

3:15 pm Siming Liu (Yumi Imai)
The loss of lipid droplet protein perilipin2 in beta cells impairs insulin secretion under nutritional stress and negatively affects mitochondrial health

3:25 pm Young Do Koo
ULK1 Regulates Hepatic Lipid Metabolism via Autophagy Independent Mechanisms

3:35 pm Antentor Hinton, Jr
OPA-1 Deficiency in Skeletal Muscle Increases Mitochondria-ER Contact Formation Through an ATF-4 Dependent Mechanism

Session III - Gene regulation and muscle biology -

2:15 pm Wade Gutierrez
Epigenetic Combination Therapy Improves Survival in Soft Tissue Sarcoma by a Novel Immune-independent Mechanism

2:25 pm Jennifer Streeter
Activating Transcription Factor 4 is required for preventing diabetes and obesity in the OPA1 skeletal muscle knock out model.

2:35 pm Tahsin Khataei
ASICs are required for immediate exercise-induced muscle pain (IEIP), but not delayed onset muscle soreness (DOMS)

2:45 pm Gavin McGivney
Tumor suppressor status alters MPNST profiles and gene expression

2:55 pm Andrea G. Marshall
How similar are they? Exploring sexual differences in the transcriptome of MuRF1 KO mice.

3:05 pm Nanmeng Yu
Understanding the role of soluble immune checkpoints in anti-tumor immunity

3:15 pm Jacilara Conceicao
Transcriptomes of Neutrophils from Individuals with Cutaneous Leishmaniasis, Subclinical L. braziliensis Infection and Healthy Controls in Northeast Brazil.

3:25 pm Ellen T. Kiser
Dietary Lipids Impact Liver Architecture, Parasite Burden, and Transcriptional Profiles During Leishmania infantum Infection

Session IV - Immunology and lung biology -

2:15 pm Shreya Ghimire
How Do Th2 and Th17 Inflammation Affect Human Airway Innate Immunity?

2:25 pm Weam Shahin
Lef-1 Promotes Ionocyte Differentiation from Submucosal Gland Stem Cells

2:35 pm Nicholas Pitcher
Whole genome sequencing identifies strains of Staphylococcus aureus responsible for persistent infections in CF.

2:45 pm Yuliang Xie
Acidic Submucosal Gland pH and Elevated Protein Concentration Produce Abnormal Cystic Fibrosis Mucus

2:55 pm Carley Stewart
An Image Analysis Approach for Assessing Mucociliary Transport in Porcine Airways

3:05 pm Lalita Mazgaeen
A protective role for CD47 in inhibiting aberrant inflammation and death of Ptpn6spin mice.

3:15 pm Alicia Eustes
Increased Thrombin Generation in COVID-19: A possible role for NETosis

3:25 pm Nandita Raikwar
Adaptive immune mechanisms contribute to cholinergic activation-mediated hypertension in Dahl salt-sensitive rats

Session V - Clinical/Outcomes Research 1 -

2:15 pm Samantha Parks
Qualitative Investigation of Factors Associated with Dietary Intervention Adherence as Perceived by Support Persons of Individuals with Multiple Sclerosis

2:25 pm Cassidy Dean
Qualitative Investigation of Facilitators and Barriers Associated with Adherence to Wahls and Swank Dietary Interventions

2:35 pm Erin Evans
Association of Epinephrine Prior to Defibrillation with Survival in Patients with In-hospital Cardiac Arrest

2:45 pm Rajeshwari Nair
Risk Adjusted Home Time as a Novel Hospital-Level Performance Metric for Pneumonia Hospitalization among Medicare Beneficiaries

2:55 pm Thorarinn A. Bjarnason
Diffusion of Percutaneous Ventricular Assist Devices In U.S. Markets

3:05 pm Danielle Riley
Hospital Variation in Incidence of In-hospital Cardiac Arrest

3:15 pm Nicholas Arnold
Improving adherence to get with the guidelines-resuscitation recommendations for management of shockable rhythms

3:25 pm Qais Radaideh
Direct Oral Anticoagulants plus antiplatelet therapy versus antiplatelet therapy alone in Patients with Peripheral Arterial Disease: Meta-analysis of Randomized Controlled Trials

3:25 pm Jai Parekh
Outcomes of Transcatheter Aortic Valve Replacement in Patients With Mixed Aortic Valve Disease Versus Pure Aortic Stenosis

Session VI - Clinical/Outcomes Research 2 -

2:15 pm Chermaine Hung
Denosumab and impact on bone health in Duchenne/Becker muscular dystrophy

2:25 pm Hari Mani
Composite Hemangioendothelioma Presenting as Bone Tumors: A Rare Case Series

2:35 pm Benjamin Chen
Late Prosthetic Shoulder Joint Infection due to Actinomyces neuii in an Adult Man

2:45 pm Homa Sadeghi
Total Blood Mercury Levels and Bone or Joint Replacement among NHANES population (2003-2004)

2:55 pm Jeff Zavala
Real-World Analysis of Time to Resolution of Milk Allergy Utilizing Baked-Milk Diet

3:05 pm Kanchna Ramchandran
Repetitive Intermittent Accelerated Transcranial magnetic stimulation (iTBS) as a potential intervention for chemotherapy induced cognitive deficits (CICD)- a pilot clinical trial to explore feasibility and efficacy.

3:15 pm Terry Wahls
Effects of Wahls Elimination and Swank Dietary Patterns on Multiple Sclerosis Related Fatigue, Quality of Life, Processing Speed and Waking Distance

3:25 pm Jennifer Lee
A Modified MCT-Based Ketogenic Diet Increases Plasma Î²-Hydroxybutyrate but Has Less Effect on Fatigue and Quality of Life in People with Multiple Sclerosis Compared to a Modified Paleolithic Diet: A Waitlist-Controlled, Randomized Pilot Study

3:25 pm Emmanuel Akintoyie
Prognostic Utility of Risk Enhancers and CAC Score Recommended in the 2018 AHA/ACC Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts

If you have any questions, please contact Cat Cigrand or Leah Pitka.

Research Day Home

1:00-2:00 pm	Keynote Presentation: From P-Hacking to Pandemics: An Editor’s Journey Toward Scientific Humility Brahmajee K. Nallamothu, MD, MPH University of Michigan
2:00-2:15 pm	break
2:15-3:15 pm	Research Mentoring Session with Q&A Dr. Nallamothu
3:15-3:30 pm	break
3:30-5:30 pm 3:30 4:00 4:30 5:00	Invited Short Presentations: Mediating Cardiac Transcription Chad Grueter, PhD, Cardiovascular Medicine Mechanisms of Microvascular Dysfunction Following Preeclamptic Pregnancy Anna Stanhewicz, PhD, Health and Human Physiology Cell-Specific Aptamer Ligands to Treat Cardiovascular Disease William Thiel, PhD, Cardiovascular Medicine Psychological Insights to Improve How We Communicate Information About Chronic and Infectious Diseases Aaron Scherer, PhD, General Internal Medicine

12:00-1:00 pm	Research Mentoring Session with Q&A Dr. Wu
1:00-2:00 pm	Keynote Presentation: Stem Cells and Genomics for Precision Medicine Joseph Wu, MD, PhD Stanford University
2:00-2:15 pm	break
2:15-4:00 pm	Concurrent Abstract Sessions (schedule of presenters below) Session I – Cardiovascular Disease Session II – Diabetes & obesity Session III – Gene regulation & muscle biology Session IV – Immunology & lung biology Session V – Clinical/Outcomes Research 1 Session VI – Clinical/Outcomes Research 2

2:15 pm	Vikram Sharma Comparison of troponin complexes and free fractions in plasma and circulation peripheral blood mononuclear cells in patients with acute myocardial infarction and end stage renal disease
2:25 pm	Nathan Lindsey Endothelial Specific Mitochondrial Calcium Uniporter Deficiency attenuates Radiation-Induced Brain Blood Barrier Leakage.
2:35 pm	Chandan Narayan Generating cardiac-specific ligands using hi-SELEX ("human-iPSC" SELEX)
2:45 pm	Jared McLendon Loss of SORBS2 in Cardiomyocytes Leads to Dilated Left Ventricle Cardiomyopathy in Mice
2:55 pm	Gabriel Baccam Cardioprotection by Klotho through Lipid Rafts
3:05 pm	Helena Kenny Cardiac specific overexpression of transcription factor EB (TFEB) results in cardiac hypertrophy, contractile dysfunction, altered mitochondrial gene profile and premature death
3:15 pm	Qian Shi Novel role of Insulin receptor substrate 2 (IRS-2) in the maintenance of cardiac calcium homeostasis
3:25 pm	Rhonda Souvenir The Absence of Uncoupling Protein -2 in Platelets Attenuates Thrombosis

2:15 pm	Joseph Skurski Loss of iRhom2 Accelerates Fat Gain and Insulin Resistance in Diet-Induced Obesity Despite Reduced Adipose Tissue Inflammation
2:25 pm	William Sivitz (Brian D. Fink) Effect of Mitoquinone on Liver Metabolism and Steatosis in Obese and Diabetic Rats
2:35 pm	Gourav Bhardwaj Loss of Insulin and IGF1 Receptors in Muscle Impairs Complex I Dependent Mitochondrial Bioenergetics and Supercomplex Formation via FoxO Transcription Factors
2:45 pm	Sarah H. Bjorkman ATF4 Expression in BAT is Required for Adaptive Thermogenesis
2:55 pm	Yuan Zhang Sex Differences in the Response of C57BL/6 Mice to Ketogenic Diets
3:05 pm	Kristen Rohli Mapping of the proinsulin interactome reveals systematic changes to proinsulin trafficking in a model of β-cell dysfunction
3:15 pm	Siming Liu (Yumi Imai) The loss of lipid droplet protein perilipin2 in beta cells impairs insulin secretion under nutritional stress and negatively affects mitochondrial health
3:25 pm	Young Do Koo ULK1 Regulates Hepatic Lipid Metabolism via Autophagy Independent Mechanisms
3:35 pm	Antentor Hinton, Jr OPA-1 Deficiency in Skeletal Muscle Increases Mitochondria-ER Contact Formation Through an ATF-4 Dependent Mechanism

2:15 pm	Wade Gutierrez Epigenetic Combination Therapy Improves Survival in Soft Tissue Sarcoma by a Novel Immune-independent Mechanism
2:25 pm	Jennifer Streeter Activating Transcription Factor 4 is required for preventing diabetes and obesity in the OPA1 skeletal muscle knock out model.
2:35 pm	Tahsin Khataei ASICs are required for immediate exercise-induced muscle pain (IEIP), but not delayed onset muscle soreness (DOMS)
2:45 pm	Gavin McGivney Tumor suppressor status alters MPNST profiles and gene expression
2:55 pm	Andrea G. Marshall How similar are they? Exploring sexual differences in the transcriptome of MuRF1 KO mice.
3:05 pm	Nanmeng Yu Understanding the role of soluble immune checkpoints in anti-tumor immunity
3:15 pm	Jacilara Conceicao Transcriptomes of Neutrophils from Individuals with Cutaneous Leishmaniasis, Subclinical L. braziliensis Infection and Healthy Controls in Northeast Brazil.
3:25 pm	Ellen T. Kiser Dietary Lipids Impact Liver Architecture, Parasite Burden, and Transcriptional Profiles During Leishmania infantum Infection

2:15 pm	Shreya Ghimire How Do Th2 and Th17 Inflammation Affect Human Airway Innate Immunity?
2:25 pm	Weam Shahin Lef-1 Promotes Ionocyte Differentiation from Submucosal Gland Stem Cells
2:35 pm	Nicholas Pitcher Whole genome sequencing identifies strains of Staphylococcus aureus responsible for persistent infections in CF.
2:45 pm	Yuliang Xie Acidic Submucosal Gland pH and Elevated Protein Concentration Produce Abnormal Cystic Fibrosis Mucus
2:55 pm	Carley Stewart An Image Analysis Approach for Assessing Mucociliary Transport in Porcine Airways
3:05 pm	Lalita Mazgaeen A protective role for CD47 in inhibiting aberrant inflammation and death of Ptpn6spin mice.
3:15 pm	Alicia Eustes Increased Thrombin Generation in COVID-19: A possible role for NETosis
3:25 pm	Nandita Raikwar Adaptive immune mechanisms contribute to cholinergic activation-mediated hypertension in Dahl salt-sensitive rats

2:15 pm	Samantha Parks Qualitative Investigation of Factors Associated with Dietary Intervention Adherence as Perceived by Support Persons of Individuals with Multiple Sclerosis
2:25 pm	Cassidy Dean Qualitative Investigation of Facilitators and Barriers Associated with Adherence to Wahls and Swank Dietary Interventions
2:35 pm	Erin Evans Association of Epinephrine Prior to Defibrillation with Survival in Patients with In-hospital Cardiac Arrest
2:45 pm	Rajeshwari Nair Risk Adjusted Home Time as a Novel Hospital-Level Performance Metric for Pneumonia Hospitalization among Medicare Beneficiaries
2:55 pm	Thorarinn A. Bjarnason Diffusion of Percutaneous Ventricular Assist Devices In U.S. Markets
3:05 pm	Danielle Riley Hospital Variation in Incidence of In-hospital Cardiac Arrest
3:15 pm	Nicholas Arnold Improving adherence to get with the guidelines-resuscitation recommendations for management of shockable rhythms
3:25 pm	Qais Radaideh Direct Oral Anticoagulants plus antiplatelet therapy versus antiplatelet therapy alone in Patients with Peripheral Arterial Disease: Meta-analysis of Randomized Controlled Trials
3:25 pm	Jai Parekh Outcomes of Transcatheter Aortic Valve Replacement in Patients With Mixed Aortic Valve Disease Versus Pure Aortic Stenosis

2:15 pm	Chermaine Hung Denosumab and impact on bone health in Duchenne/Becker muscular dystrophy
2:25 pm	Hari Mani Composite Hemangioendothelioma Presenting as Bone Tumors: A Rare Case Series
2:35 pm	Benjamin Chen Late Prosthetic Shoulder Joint Infection due to Actinomyces neuii in an Adult Man
2:45 pm	Homa Sadeghi Total Blood Mercury Levels and Bone or Joint Replacement among NHANES population (2003-2004)
2:55 pm	Jeff Zavala Real-World Analysis of Time to Resolution of Milk Allergy Utilizing Baked-Milk Diet
3:05 pm	Kanchna Ramchandran Repetitive Intermittent Accelerated Transcranial magnetic stimulation (iTBS) as a potential intervention for chemotherapy induced cognitive deficits (CICD)- a pilot clinical trial to explore feasibility and efficacy.
3:15 pm	Terry Wahls Effects of Wahls Elimination and Swank Dietary Patterns on Multiple Sclerosis Related Fatigue, Quality of Life, Processing Speed and Waking Distance
3:25 pm	Jennifer Lee A Modified MCT-Based Ketogenic Diet Increases Plasma Î²-Hydroxybutyrate but Has Less Effect on Fatigue and Quality of Life in People with Multiple Sclerosis Compared to a Modified Paleolithic Diet: A Waitlist-Controlled, Randomized Pilot Study
3:25 pm	Emmanuel Akintoyie Prognostic Utility of Risk Enhancers and CAC Score Recommended in the 2018 AHA/ACC Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts