Department of Internal Medicine Intranet

Department of Internal Medicine Research Day

Research Day Schedule:

Thursday, September 26, 2024

12:00-1:00pm Keynote Presentation - Medical Alumni Auditorium, E331 GH

Metabolically healthy and unhealthy obesity

Samuel Klein, MD
William H. Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Nutritional Science & Obesity Medicine
Director, Nutrition Obesity Research Center (NORC)
Director, Weight Management Program
Washington University School of Medicine

1:15-2:45pm

Invited Short Presentations - Watzke Auditorium, BSB Aud 3

Dissecting metabolic failure of the pancreatic beta-cell in Type 2 diabetes
Samuel Stephens, PhD, Associate Professor, Division of Endocrinology and Metabolism

The role of iRhom2 in fat cell function and immune responses during obesity
Thorsten Maretzky, PhD, Assistant Professor, Division of Infectious Diseases

Leveraging microbial actions to improve heart health
Ajit Vikram, PhD, Assistant Professor, Division of Cardiovascular Medicine

CFTR is essential for endothelium-dependent vasorelaxation
Shravan K. Uppulapu, PhD, Postdoctoral Research Scholar, Division of Cardiovascular Medicine
Proto-oncogene HRAS transcript level predicts overall survival in stage II and III colorectal cancer
Donghyun Kim, MD, PhD, Second-Year Fellow, Hematology and Medical Oncology

2:45-4:00pm Poster session - Atrium, MERF

Poster Session

1 Yang Yu
Inhibition of RORÎ³t Ameliorates Angiotensin II-Induced Blood-Brain Barrier Disruption and Microglia Activation by Reducing Interleukin-17A Production in Rats

2 Nusaira Beenta Shahab
Role of Angiotensin II on Cardiovascular/Autonomic Function and Cognition in a Novel Mouse Model of Alzheimerâ€™s Disease

3 Jordan Hook
Examining Clinical Outcomes of Multiple Sclerosis Patients Who Utilized Diet as Part of Their Personal Treatment Plan: A Longitudinal Study

4 Trisha Slehria
Integration of obstetrical and gynecological history during cardiovascular disease risk assessment

5 Mohanraj Sadasivam
DLL3-Targeted Pan-Î³Î´ T Cell Engagers for Enhanced SCLC Immunotherapy

6 Akshaya Warrier
Identification of metabolic vulnerabilities in malignant peripheral nerve sheath tumors

7 Mark Yorek
Effects Of Fish Oil Â± Salsalate On The Omega-3 Index And The Circulating Lipodome Of Omega-3 Polyunsaturated Fatty Acid Metabolites In Patients With Type 2 Diabetes And Diabetic Neuropathy Â€Œtinsal Fishâ€

8 Ethan Chen
Very Low-Calorie Diet for Metabolic Dysfunction-Associated Steatotic Liver Disease in Obesity

9 Nathan Witmer
Upstream alternative polyadenylation in SCN5A produces a short transcript isoform encoding a mitochondria-localized NaV1.5 N-terminal fragment that influences cardiomyocyte respiration

10 Hanna Paton
Dissecting the multifaceted roles of CD47 during cutaneous L. major infection

11 Elizabeth Wagstaff
Meningoencephalitis Associated with Archetype-like JC Polyomavirus and Complete Neurological Recovery

12 Nina Carnevale
Therapeutic targeting of PRC2-driven MPNST metastasis

13 Jasmyn Hoeger
Translational Control of Cardiac Gene Expression through Alternative Open Reading Frames

14 Kayla Henry
Cardiomyocyte-Specific Deletion of Med13 & Med13L Results in Dysregulated Gene Expression and Lethal Systolic Heart Failure

15 Kyle Westhoff
Effects of radiation on cerebral microvessels and mitochondrial activity

16 Srija Manchkanti
Estrogen Therapy is Associated with a Greater Prevalence of Cardiac, Renal, Hepatic and Metabolic Outcomes in Cisgender Women, but Partially Spares Transgender Women: A Global Retrospective Study

17 Aravinthasamy Sivamurugan
Comparison of Cardiovascular Outcomes in Patients receiving FLOT versus Carboplatin/Paclitaxel prior to Esophagectomy for Esophageal Adenocarcinoma

18 Amy O'Shea
Understanding Telemedicine Preferences, Experiences, and Barriers to Improve Access and Healthcare Utilization for Rural Veterans

19 Blake Bernauer
Cytokine and JC plasma-induced activation of Natural Killer cells in response to JC Virus infection

20 Andrew Polgreen
Sailing broad reach: Angled transport by airway cilia

21 Izola Ramalho
Women with a History of Preeclampsia Demonstrate Increased Platelet Activation without Increased Coagulation

22 Sandra Blom
Proinflammatory cytokines alter Î²-cell Golgi structure and function via GRASP55 and iNOS

23 Katherine (KB) Butler
The effect of infectious and inflammatory stimuli on the synovium and resident synovial macrophages in a novel human explant model

24 Gokul Patil
Persistent Prothrombotic State in Post-Acute Sequelae of Mild SARS-CoV-2 Infection: Role of Extracellular Histones and Immune Complexes

25 Jack Siemering
Neuroimmune and inflammatory responses to Simian Immunodeficiency Virus (SIVsabaeus) in the central nervous system of African green monkeys

26 Weijie Du
Hypoxia slows cilia beating in airway epithelia

27 Josh Peterson
Synergistic Effects of FGF21 and GDF15 During Mitochondrial Stress in Brown Adipose Tissue

28 steven bullard
Upregulation of Ancient Spiggin Homolog MUC19 in MUC5B Knockout Pigs: Insights into Mucosal Dynamics

29 Heather Davila
Sex differences in discharge location and 30-day outcomes following total knee or total hip replacement in the Veterans Health Administration

30 brie hilkin
Early Intervention with Ivacaftor Reverses Mucociliary Transport Defects in Neonatal G551D Piglets

31 Adam Blaine
Point of Care Ultrasound Education and Resources at Fort Portal Regional Referral Hospital

32 Saurabh Saini
Receptor-interacting protein kinase 2 (RIPK2) regulated gut microbiota promotes acute radiation syndrome.

33 Azaj Ahmed
Prediabetes increases platelet activation and thrombotic susceptibility via mitochondrial oxidants.

34 Austin Paden
Listeria monocytogenes and Sounding the Alarm: Cytoplasmic Sensors Crucial for Survival

35 Grace Peil
GPx1 Modifies Migration and EMT in Colon Cancer Cells

36 Alyanne Bastian & Arturo Martinez
Effects of a diet-based multi-modal intervention on cardiometabolic markers in people with progressive MS: A secondary analysis of a pilot study

37 Prabuddha Sarkar
Sexual Dimorphism in the Inflammatory Response to Lipopolysaccharide in Mice

38 Omar Aristizabal
Viral Pathogenesis In The Brain Of Rhesus Macaques During Acute Siv Infection Treated With A Bispecific Antibody

39 Linda Powers
Engaging citizen science to track and reduce energy use in laboratories.

40 Peter James Szachowicz
Complement activation in an intraperitoneal bleomycin model of pulmonary fibrosis

41 Roger D. Struble, MD, MPH
Estimating Time in Patient Rooms of Physicians and Other Healthcare Providers in an Intensive care Unit Using a Sensor Network

42 Donghyun Kim
Proto-oncogene HRAS transcript level predicts overall survival in stage II and III colorectal cancer

43 Marvis Monteiro
FGFR signaling inhibits STAT1 phosphorylation in dormant breast cancer cells

44 Corinne Bovee
Phosphorylation of Perilipin 5 S155 is dynamic in mice in vivo and regulates Insulin Receptor Substrate 2 expression in the liver

45 Ashten Sherman
Eosinophilia is Associated with Chronic Lung Allograft Dysfunction and Survival Following Lung Transplantation

46 Winter Philibert
Oxidative Stress and Mucus Viscoelasticity in Cystic Fibrosis

47 Casey Hardin, MD
Low Baseline Creatinine Reduces the Likelihood of Nephrology Consultation in Stage 3 Acute Kidney Injury

48 Kimberly Dukes
Facilitators and Barriers for the Use of Ultraviolet-C Disinfection for Patient Rooms at VA Hospitals: A Qualitative Analysis

49 Matthew Gao
E-cigarette exposure induces endothelial activation and alters the phenotype of circulating monocytes

50 Dana Tasabehji
Investigating A Link Between Sympathetic Nervous System And T-Regulatory Cells In Roux-En-Y-Gastric Bypass

51 Justin Holmes
Recognizing Repercussions of Recurrent Rapid Response Events

52 Sanaz Saleh
Sleeve Gastrectomy versus Gastroplasty: Effects on Weight, Glucose Regulation, and Hormonal Profiles in Mice

53 Cameron Brownlee
An Unusual Case of Massive Hemoptysis

54 MariaJose Valera-Brush
Adrenal tumor with invasion of the Inferior Vena Cava extending into the right atrium

55 Austin Mallory
From Sniffles to Struggles: A Cold That Pulled No Punches in RA and ILD

56 Jarvis, Natalie
Dietary effects on the course of visceral leishmaniasis in a mouse model.

57 Mohamed Fawzi Mudarres
A Case of Renal Artery Thrombosis With Concurrent Adrenal Hemorrhage in Polycythemia Vera

58 Shravan k Uppulapu
CFTR is essential for endothelium-dependent vasorelaxation

59 Gatr-alnada Gheriani
Establishing a Multidisciplinary Clinic to Enhance Care for Vasculitis Patients

60 Melissa Swee
Enhancing Access to Nephrology Care: The Redesign of a Telenephrology Dashboard via Human-Centered Design

61 Rakesh B. Patel
von Willebrand factor deficiency improves long-term stroke outcomes in mice with respiratory infections

62 Jamal Naderi
Ceramide-Induced FGF13 Disrupts Nutrient Sensing and Contributes to Metabolic Dysfunction

63 Michael Rector
Progression Of Lung Disease In A Porcine Model Of Primary Ciliary Dyskinesia

64 Sarah Ernst
Reducing Waste and Energy Usage in Research Laboratories

65 Olumayokun Akinbo
Immunologic Correlates of Lung Abnormalities in Post-Acute Sequela of COVID-19

66 Maya Barros
Next generation aptamers for targeting both human and mouse vascular smooth muscle cells in treating various vascular disorders

67 Joshua Kettelkamp
Defining Computable Phenotypes for Immunosuppressant related Complications after Kidney Transplant

68 Betty H Tu
Revisiting the Lille Score: A Measure of Survival, rather than Steroid Response, in Patients with Acute Alcohol-Associated Hepatitis?

69 Jason Gao
Optimized Recovery of Coronary Artery Endothelial Cells for Aptamer-Based Recovery

70 Andrea Milenia Benavides
E-cigarette use alters the epigenetic landscape of circulating monocytes in a sex-specific manner

71 Boulos Nassar MD
Emergency Response Team

72 Vinnyfred Vincent
The role of ceramide induced Bone Morphogenetic Protein 3 on adipocyte metabolism

73 Maria Isabel Aguilar Pescozo, MD
The effect of heated, humidified high-flow air in COPD patients with chronic bronchitis.

74 Miles Hagner
The Role of B Cells during Granuloma Formation in Sarcoidosis

If you have any questions, please contact Lori Strommer Pace.

Research Day Home

1	Yang Yu Inhibition of RORÎ³t Ameliorates Angiotensin II-Induced Blood-Brain Barrier Disruption and Microglia Activation by Reducing Interleukin-17A Production in Rats
2	Nusaira Beenta Shahab Role of Angiotensin II on Cardiovascular/Autonomic Function and Cognition in a Novel Mouse Model of Alzheimerâ€™s Disease
3	Jordan Hook Examining Clinical Outcomes of Multiple Sclerosis Patients Who Utilized Diet as Part of Their Personal Treatment Plan: A Longitudinal Study
4	Trisha Slehria Integration of obstetrical and gynecological history during cardiovascular disease risk assessment
5	Mohanraj Sadasivam DLL3-Targeted Pan-Î³Î´ T Cell Engagers for Enhanced SCLC Immunotherapy
6	Akshaya Warrier Identification of metabolic vulnerabilities in malignant peripheral nerve sheath tumors
7	Mark Yorek Effects Of Fish Oil Â± Salsalate On The Omega-3 Index And The Circulating Lipodome Of Omega-3 Polyunsaturated Fatty Acid Metabolites In Patients With Type 2 Diabetes And Diabetic Neuropathy Â€Œtinsal Fishâ€
8	Ethan Chen Very Low-Calorie Diet for Metabolic Dysfunction-Associated Steatotic Liver Disease in Obesity
9	Nathan Witmer Upstream alternative polyadenylation in SCN5A produces a short transcript isoform encoding a mitochondria-localized NaV1.5 N-terminal fragment that influences cardiomyocyte respiration
10	Hanna Paton Dissecting the multifaceted roles of CD47 during cutaneous L. major infection
11	Elizabeth Wagstaff Meningoencephalitis Associated with Archetype-like JC Polyomavirus and Complete Neurological Recovery
12	Nina Carnevale Therapeutic targeting of PRC2-driven MPNST metastasis
13	Jasmyn Hoeger Translational Control of Cardiac Gene Expression through Alternative Open Reading Frames
14	Kayla Henry Cardiomyocyte-Specific Deletion of Med13 & Med13L Results in Dysregulated Gene Expression and Lethal Systolic Heart Failure
15	Kyle Westhoff Effects of radiation on cerebral microvessels and mitochondrial activity
16	Srija Manchkanti Estrogen Therapy is Associated with a Greater Prevalence of Cardiac, Renal, Hepatic and Metabolic Outcomes in Cisgender Women, but Partially Spares Transgender Women: A Global Retrospective Study
17	Aravinthasamy Sivamurugan Comparison of Cardiovascular Outcomes in Patients receiving FLOT versus Carboplatin/Paclitaxel prior to Esophagectomy for Esophageal Adenocarcinoma
18	Amy O'Shea Understanding Telemedicine Preferences, Experiences, and Barriers to Improve Access and Healthcare Utilization for Rural Veterans
19	Blake Bernauer Cytokine and JC plasma-induced activation of Natural Killer cells in response to JC Virus infection
20	Andrew Polgreen Sailing broad reach: Angled transport by airway cilia
21	Izola Ramalho Women with a History of Preeclampsia Demonstrate Increased Platelet Activation without Increased Coagulation
22	Sandra Blom Proinflammatory cytokines alter Î²-cell Golgi structure and function via GRASP55 and iNOS
23	Katherine (KB) Butler The effect of infectious and inflammatory stimuli on the synovium and resident synovial macrophages in a novel human explant model
24	Gokul Patil Persistent Prothrombotic State in Post-Acute Sequelae of Mild SARS-CoV-2 Infection: Role of Extracellular Histones and Immune Complexes
25	Jack Siemering Neuroimmune and inflammatory responses to Simian Immunodeficiency Virus (SIVsabaeus) in the central nervous system of African green monkeys
26	Weijie Du Hypoxia slows cilia beating in airway epithelia
27	Josh Peterson Synergistic Effects of FGF21 and GDF15 During Mitochondrial Stress in Brown Adipose Tissue
28	steven bullard Upregulation of Ancient Spiggin Homolog MUC19 in MUC5B Knockout Pigs: Insights into Mucosal Dynamics
29	Heather Davila Sex differences in discharge location and 30-day outcomes following total knee or total hip replacement in the Veterans Health Administration
30	brie hilkin Early Intervention with Ivacaftor Reverses Mucociliary Transport Defects in Neonatal G551D Piglets
31	Adam Blaine Point of Care Ultrasound Education and Resources at Fort Portal Regional Referral Hospital
32	Saurabh Saini Receptor-interacting protein kinase 2 (RIPK2) regulated gut microbiota promotes acute radiation syndrome.
33	Azaj Ahmed Prediabetes increases platelet activation and thrombotic susceptibility via mitochondrial oxidants.
34	Austin Paden Listeria monocytogenes and Sounding the Alarm: Cytoplasmic Sensors Crucial for Survival
35	Grace Peil GPx1 Modifies Migration and EMT in Colon Cancer Cells
36	Alyanne Bastian & Arturo Martinez Effects of a diet-based multi-modal intervention on cardiometabolic markers in people with progressive MS: A secondary analysis of a pilot study
37	Prabuddha Sarkar Sexual Dimorphism in the Inflammatory Response to Lipopolysaccharide in Mice
38	Omar Aristizabal Viral Pathogenesis In The Brain Of Rhesus Macaques During Acute Siv Infection Treated With A Bispecific Antibody
39	Linda Powers Engaging citizen science to track and reduce energy use in laboratories.
40	Peter James Szachowicz Complement activation in an intraperitoneal bleomycin model of pulmonary fibrosis
41	Roger D. Struble, MD, MPH Estimating Time in Patient Rooms of Physicians and Other Healthcare Providers in an Intensive care Unit Using a Sensor Network
42	Donghyun Kim Proto-oncogene HRAS transcript level predicts overall survival in stage II and III colorectal cancer
43	Marvis Monteiro FGFR signaling inhibits STAT1 phosphorylation in dormant breast cancer cells
44	Corinne Bovee Phosphorylation of Perilipin 5 S155 is dynamic in mice in vivo and regulates Insulin Receptor Substrate 2 expression in the liver
45	Ashten Sherman Eosinophilia is Associated with Chronic Lung Allograft Dysfunction and Survival Following Lung Transplantation
46	Winter Philibert Oxidative Stress and Mucus Viscoelasticity in Cystic Fibrosis
47	Casey Hardin, MD Low Baseline Creatinine Reduces the Likelihood of Nephrology Consultation in Stage 3 Acute Kidney Injury
48	Kimberly Dukes Facilitators and Barriers for the Use of Ultraviolet-C Disinfection for Patient Rooms at VA Hospitals: A Qualitative Analysis
49	Matthew Gao E-cigarette exposure induces endothelial activation and alters the phenotype of circulating monocytes
50	Dana Tasabehji Investigating A Link Between Sympathetic Nervous System And T-Regulatory Cells In Roux-En-Y-Gastric Bypass
51	Justin Holmes Recognizing Repercussions of Recurrent Rapid Response Events
52	Sanaz Saleh Sleeve Gastrectomy versus Gastroplasty: Effects on Weight, Glucose Regulation, and Hormonal Profiles in Mice
53	Cameron Brownlee An Unusual Case of Massive Hemoptysis
54	MariaJose Valera-Brush Adrenal tumor with invasion of the Inferior Vena Cava extending into the right atrium
55	Austin Mallory From Sniffles to Struggles: A Cold That Pulled No Punches in RA and ILD
56	Jarvis, Natalie Dietary effects on the course of visceral leishmaniasis in a mouse model.
57	Mohamed Fawzi Mudarres A Case of Renal Artery Thrombosis With Concurrent Adrenal Hemorrhage in Polycythemia Vera
58	Shravan k Uppulapu CFTR is essential for endothelium-dependent vasorelaxation
59	Gatr-alnada Gheriani Establishing a Multidisciplinary Clinic to Enhance Care for Vasculitis Patients
60	Melissa Swee Enhancing Access to Nephrology Care: The Redesign of a Telenephrology Dashboard via Human-Centered Design
61	Rakesh B. Patel von Willebrand factor deficiency improves long-term stroke outcomes in mice with respiratory infections
62	Jamal Naderi Ceramide-Induced FGF13 Disrupts Nutrient Sensing and Contributes to Metabolic Dysfunction
63	Michael Rector Progression Of Lung Disease In A Porcine Model Of Primary Ciliary Dyskinesia
64	Sarah Ernst Reducing Waste and Energy Usage in Research Laboratories
65	Olumayokun Akinbo Immunologic Correlates of Lung Abnormalities in Post-Acute Sequela of COVID-19
66	Maya Barros Next generation aptamers for targeting both human and mouse vascular smooth muscle cells in treating various vascular disorders
67	Joshua Kettelkamp Defining Computable Phenotypes for Immunosuppressant related Complications after Kidney Transplant
68	Betty H Tu Revisiting the Lille Score: A Measure of Survival, rather than Steroid Response, in Patients with Acute Alcohol-Associated Hepatitis?
69	Jason Gao Optimized Recovery of Coronary Artery Endothelial Cells for Aptamer-Based Recovery
70	Andrea Milenia Benavides E-cigarette use alters the epigenetic landscape of circulating monocytes in a sex-specific manner
71	Boulos Nassar MD Emergency Response Team
72	Vinnyfred Vincent The role of ceramide induced Bone Morphogenetic Protein 3 on adipocyte metabolism
73	Maria Isabel Aguilar Pescozo, MD The effect of heated, humidified high-flow air in COPD patients with chronic bronchitis.
74	Miles Hagner The Role of B Cells during Granuloma Formation in Sarcoidosis