Department of Internal Medicine

Pulmonary, Critical Care and
Occupational Medicine Faculty

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Lakshmi Durairaj, M.B.B.S., M.S.
Assistant Professor

Dr. Durairaj's main focus is in translational research in airway infections and immunity. Her current studies include xylitol for exacerbation of cystic fibrosis, genetics of ventilator associated pneumonia and assessment of biomarkers in lung fluid in critically ill patients.

Honors, Awards and Organizations:

• NIH UOI award for a phase II clinical trial of novel therapies in lung disease. 2010-2013
• NIH K23 career development award, 2005- 2010
• Mentored career development award (NIH K12), 2004-2005
• American Lung Association clinical research award, 2004
• American Thoracic Society 2004-

Recent Publications

1. Ray, N, Durairaj L et al; Dynamic regulation of cardiolipin by the lipid pump, Atp8b1, determines the severity of lung injury in experimental pneumonia: Nature Med 2010: (10):1120-7
2. Durairaj, L, Mohamad Z, Launspach J, et al; Patterns and density of early tracheal colonization in intensive care unit patients. J Crit Care. 2009; 24(1):114-21
3. Durairaj L, Schmidt GA: “Fluid therapy in resuscitated sepsis; less is more.” Chest 2008; 133:1; 252-63
4. Durairaj L, Launspach J, Watt JL, et al: “Safety assessment of inhaled xylitol in subjects with cystic fibrosis.“J Cyst Fibrosis. 2007;1:31-4
5. Durairaj L, Neelakantan S, Launspach J et al. “Bronchoscopic Assessment of Airway Retention Time of Aerosolized Xylitol.” Respiratory Research 2006;7:27
6. Durairaj L, Torner JC, et al: “Hospital volume-outcome relationship among medical admissions to intensive care units.” Chest 2005: 128; 1682-1689
7. Durairaj L, Launspach J, Watt JL, et al: “Safety assessment of inhaled xylitol in mice and healthy volunteers.” Respir Res 2004; 5:13
8. Durairaj L, Will JG, Torner J et al; “Prognostic Factors for Mortality Following Interhospital Transfers to the Medical Intensive Care Unit of a Tertiary Referral Center.” Crit Care Med 2003; 31:1981-1986
9. Evans A, Husain S, Durairaj L et al; “Azithromycin for Acute Bronchitis: a randomized controlled trial.” Lancet 2002; 359: 1648-54
10. Wester CW, Durairaj L et al; “Antibiotic Resistance: A Survey of physician perceptions.” Arch of Int Med 2002, Oct 2002.
11. Durairaj L, Reilly B, et al; “Emergency Department Admissions to Inpatient Cardiac Telemetry Unit.” Am J Med 2001; 110: 7-11

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