Department of Internal Medicine
Pulmonary, Critical Care and
Occupational Medicine Faculty
A. Brent Carter, M.D.
Dr. Carter’s clinical interests include pulmonary fibrosis, asthma, and acute lung injury. His research interests are related to the regulation of inflammatory and fibrotic responses that occur in the lung in models of acute lung injury and pulmonary fibrosis. These studies include investigations dealing with the role of reactive oxygen species and antioxidant enzymes in the development of inflammatory/fibrotic response and the regulation of the signal transduction pathways in monocytes and macrophages that induce the development of pulmonary fibrosis. This work is supported by grants from the National Institutes of Health.
Honors, Awards, and Organizations
- American Thoracic Society, Member
- American College of Chest Physicians, Fellow
- American College of Physicians, Member
- Samuel, I., Tephly, L., Williard, D.E., Zaheer, A., Carter, A.B. Enteral exclusion increases map kinase activation and cytokine production in a model of gallstone pancreatitis. Pancreatology (In press), 2007.
- Tephly, L.A. and Carter, A.B. Constitutive NADPH oxidase and increased mitochondrial respiratory chain activity regulate chemokine gene expression. Am. J. Physiol: Lung Cell. Mol. Physiol. (In press), 2007.
- Tephly, L.A. and Carter, A.B. Differential expression and oxidation of MKP-1 modulates TNF-? gene expression. Am. Jour. Resp. Cell Mol. Biol. 37:366-374, 2007.
- Agassandian M., Zhou J., Tephly, L.A., Carter, A.B., and Mallampalli, R.K. Oxysterols inhibit surfactant phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase J. Biol. Chem. 280:21577-21587, 2005.
- Carter, A.B., Tephly, L.A., Venkataraman, S., Oberley, L.W., Zhang, Y., Buettner, G. R., Spitz, D.R. and Hunninghake, G.W. High levels of catalase and glutathione peroxidase activity dampens hydrogen peroxide signaling in human alveolar macrophages. Am. J. Resp. Cell Mo. Biol. 31:43-53, 2004.
- Carter, A.B., Monick, M.M., and Hunninghake, G.W.: Both ERK and p38 kinases are necessary for cytokine gene transcription. Am. J. Respir. Cell Mol. Biol. 20 :751-758, 1999.
- Carter, A.B., and Hornick, D.B.: Therapy for ventilator-associated pneumonia. Clin. Chest Med. 20:681-691, 1999.
- Monick, M.M., Carter, A.B., and Hunninghake, G.W.: Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA-binding activity. J. Biol. Chem. 274 (25):18075-18080, 1999.
- Carter, A.B., Knudtson, K., Monick, M.M., and Hunninghake, G.W.: The p38 mitogen-activated protein kinase is required for NF- k B-dependent gene expression: The role of TATA-binding protein (TBP). J. Biol. Chem. 274 :30858-63, 1999.