Department of Internal Medicine
Infectious Diseases Faculty
Medical School:
B.S., State University of New York, Stony Brook
Ph.D., New York University
Jerrold P. Weiss, Ph.D.
Professor
Dr. Weiss' main research interest is neutrophil host defense. His main concern is innate mechanisms of host defense against bacteria. Major foci include the molecular basis of nonoxidative cellular and extracellular antibacterial cytotoxicity, molecular and cellular determinants of action of defined lipid deacylases in inflammatory settings, and regulation of host cell signaling by LPS. His studies have led to the identification, characterization, and preclinical development of bactericidal/permeability-increasing protein(BPI), and LPS-binding neutrophil granule protein with highly potent and selective cytotoxicity toward Gram-negative bacteria and endotoxin-neutralizing activity.
Recent Publications
- Iovine, N.M., Elsbach, P., and Weiss, J.: An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N-and C- terminal domains. Proc. Natl. Acad. Sci. U.S.A. 94:10973-10978,1997.
- Weinrauch, Y., Abad, C., Liang, N.C., Lowry, S.F., and Weiss, J.: Mobilization of potent plasma bactericidal activity during systemic bacterial challenge: role of group IIA phospholipase A2 .J. Clin. Invest .102: 633-638,1998.
- Foreman-Wykert, A.K., Weinrauch, Y., Elsbach, P., and Weiss, J.: Cell wall determinants of the bactericidal action of group IIA phospholipase A2 against gram- positive bacteria. J. Clin. Invest. 103:715- 721,1999.
- Katz, S.S., Weinrauch, Y., Munford, R.S., Elsbach, P., and Weiss, J.: Lipopolysaccha- ride deacylation following extracellular or intracellular killing of Escherichia coli by rabbit inflammatory peritoneal exudates. J. Biol. Chem .274: 36579-36584,1999.
Links of Interest