Department of Internal Medicine

Hematology, Oncology and Blood &  Marrow Transplantation Faculty

Medical School:
University of Porto, Portugal

Residency:
University of Porto, Portugal
Cook County Hospital, Chicago

Fellowship:
M.D. Anderson Cancer Center, Houston
University of Illinois
Case Western Reserve University

Margarida deMagalhaes-Silverman, M.D.
Clinical Professor

Dr. deMagalhaes-Silverman's clinical and research interests focus on new applications of  stem cell transplantation, development of new conditioning regimens, and therapy for post transplant residual disease.

Honors, Awards, and Organizations

• Cripp Award for Clinician, 1997
• American Society of Clinical Oncology
• American Society of Hematology
• American College of Physicians
• American Society for Blood and Marrow Transplantation
• European Haematology Association
• Member, International Immunocompromised Host Society
• Member, Canadian Blood & Marrow Transplantation Group
• Member, International Society for Hematotherapy and Graft Engineering

Recent Publications

1. Giles, F.J., Rodriguez, R., Weisdorf, D., Wingard, J.R., Martin, P.J., Fleming, T.R., Goldberg, S.L., Anaissie, E.J., Bolwell, B.J., Chao, N.J., Shea, T.C., Brunvan, M.M., Vaughan, W., Petersen, F., Schubert, M., Lazarus, H.M., Maziarz, R.T., Silverman, M., Beveridge, R.A., Redman, R., Pulliam, J.G., Devitt-Risse, P., Fuchs, H.J., Hurd, D.D.: A Phase III randomized, double blind, placebo-controlled, study of iseganan for the receiving stomatotoxic chemotherapy. Leukemia Res. 2004 Jun;28(6):559-65.
2. Siwek, G.T., Dodgson, K.J., Magalhaes-Silverman, M., Bartlet, L.A., Kilborn, S.B., Hoth, P.L., Diekema, D.J., Pfaller, M.A. Invasive Zygomycosis in hematopoietic stem-cell transplant patients receiving voriconazole prophylaxis. - Clin Infect Dis, 2004 (in press)
3. Hamawi, Khaled, deMagalhaes-Silverman, M., and Bertolatus, Andrew J., Outcomes of Renal Transplantation Following Bone Marrow Transplantation. Accepted American Journal of Transplantation 2003; 3: 301-305.
4. DeMagalhaes-Silverman, M., Lister, J., Rybka, W., Wilson J., Ball ED: Busulfan and cyclophosphamide (BU/CY2) as preparative regimen for patients with lymphoma. Bone Marrow Transplant, 19: 777-781, 1997.
5. DeMagalhaes-Silverman, M., Bloom E, Lembersky B, Lister J, Pincus S, Rybka W, Voloshin M Wilson J, Ball ED. High dose chemotherapy and autologous stem cell support followed by post transplant doxorubicin as initial therapy for metastatic breast cancer. Clinical Cancer Research, 3: 193-197, 1997.
6. DeMagalhaes-Silverman, M., Lembersky, B., Lister, J., Rybka W., Wilson, J., and Ball E.D.: High-dose chemotherapy and autologous stem cell support followed by post transplant doxorubicin and taxol as initial therapy for metastatic breast cancer. Bone Marrow Transplant, 21:1207-1212, 1998.
7. DeMagalhaes-Silverman M, Donnenberg A, Hammert L et al: Factors influencing mobilization and engraftment is patients ( pts) with metastatic breast cancer (MBC) undergoing peripheral blood stem cell transplantation. J. Hematotherapy, 2 167-172, 1999.
8. Rodrigues GA, Lee Ck, deMagalhaes-Silverman M. Human herpes virus 6 and fatal encephalitis in a bone marrow recipient. Scandinavian Journal of Infectious Diseases, 31: 313-15, 1999.
9. DeMagalhaes-Silverman M, Donnenberg A, Lembersky B et al: Post transplant adoptive immunotherapy with activated natural killer cells in patients with metastatic breast cancer. Journal of immunotherapy, 23; 154-60, 2000.
10. Lee CK, deMagalhaes-Silverman M, Hayashi M, Schlueter A, Strauss R, Gingrich R: Dose escalation study for salvage chemotherapy for patients with refractory lymphoma, prior to the high dose myeloablative therapy with stem cell transplantation. Accepted for publication Bone Marrow Transplant, 2002, 29: 647-52.
11. Lee C.K, Gingrich RD., deMagalhaes-Silverman M, Hohl R, Hayashi M, Buatti J, Wen BC, Schlueter A, Strauss RG: Prophylactic T Cell Infusion after T-Cell-Depleted Bone Marrow Transplantation in Patients with Refractory Lymphoma. Bone Marrow Transplant, 2002, 29: 615-20.
12. Lee CK, deMagalhaes-Silverman M, Hohl R, Hayashi M, Buatti J, Chen-Wen B, Schlueter A, Strauss R, Gingrich R: Donor T lymphocytes infusion for Unrelated Allogeneic Bone Marrow Transplantation with CD3 + T cell depleted graft. Biology Bone Marrow Transplant. 2003, 2: 121-128.
13. deMagalhaes-Silverman M, Lee CK, Hohl R, Schleuter A, Ritchie J, Gingrich R: Allogeneic Transplantation of CD34+ Selected Peripheral Blood Progenitor Cell from HLA Matched Identical Siblings Followed by Pre-emptive T-cell Add-back. A faculty study. Stem Cell and Cellular Therapy. 1. 21-28. 2003.