Department of Internal Medicine

Hematology, Oncology and Blood &  Marrow Transplantation Faculty

James McNamara, Ph.D.

Graduate School:
Duke University

Post-Doctoral Training:
Duke University

James O. McNamara, Ph.D.
Assistant Professor

Dr. McNamara's research focuses on the development of RNA-based therapeutic approaches for neurological disorders.

Honors, Awards, and Organizations

Recent Publications

  1. Dassie JP, Liu X-Y, Thomas GS, Whitaker RM, Thiel KW, , Stockdale KR, Meyerholz DK, McCaffrey AP, McNamara JO, Giangrande PH. Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotech. 27:839-846, 2009.
  2. McNamara JO, Kolonias D, Pastor F, Mittler RS, Chen L, Giangrande PH, Sullenger B, Gilboa E. Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. J Clin Invest. 118(1):376-86, 2008.
  3. McNamara JO, Andrechek E, Wang Y, Viles KD, Rempel RE, Gilboa E, Sullenger BA, Giangrande PH. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotech. 24(8):1005-1015, 2006.
  4. Grigston JC, VanDongen HM, McNamara JO, VanDongen AM. Translation of an integral membrane protein in distal dendrites of hippocampal neurons. Eur J Neurosci. 6:1457-68, 2005.
  5. McNamara JO, Grigston JC, VanDongen HM, VanDongen AM. Rapid dendritic transport of TGN38, a putative cargo receptor. Brain Res Mol Brain Res. 127(1-2):68-78, 2004.

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