Department of Internal Medicine
Cardiovascular Medicine Faculty
Graduate School:
Case Western Reserve University
Postdoctoral Fellowship:
Washington University
Thomas J. Hund, Ph.D.
Assistant Professor of Medicine and Biomedical Engineering
Dr. Hund's research interests include computer modeling of the cardiac action potential, calcium transient and intracellular signaling pathways, the role of CaMKII in electrical remodeling and arrhythmias post-infarction, and regulation of gap junctions and cell-cell communication during myocardial ischemia.
Honors, Awards, and Organizations
- Ruth L. Kirchstein National Research Service Award, NIH, 2006
- NIH Pathway to Independence Award (K99/R00), 2009
- Early Career Author’s Prize – International Society for Heart Research/Journal of Molecular and Cellular Cardiology, 2008
Links of Interest
Select Publications
- Koval OM, Guan X, Wu Y, Joiner M, Gao Z, Chen B, Grumbach IM, Luczak ED, Colbran RJ, Song LS, Hund TJ, Mohler PJ, and Anderson ME. The Cav1.2 β subunit coordinates CaMKII-triggered cardiomyocyte death and after depolarizations. Proc Natl Acad Sci U S A. 2010; 107:4996-5000.
- Christensen MD, Dun W, Boyden PA, Anderson ME, Mohler PJ, and Hund TJ. Oxidized calmodulin kinase II regulates conduction following myocardial infarction: A computational analysis. PLoS Comput Biol. 2009; 5:e1000583.
- Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke WJ, Sarma S, Grumbach IM, Wehrens XHT, Song LS, Mohler PJ, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009; 106:5972-7.
- Kline CF, Kurata HT, Hund TJ, Cunha SR, Koval OM, Wright PJ, Christensen M, Anderson ME, Nichols CG, and Mohler PJ. Dual role of KATP channel C-terminal motif in membrane targeting and metabolic regulation. Proc Natl Acad Sci U S A. 2009; 106:16663-16668.
- Hund, T.J., Wright, P., Dun, W., Snyder, J.S., Boyden, P.A., and Mohler, P.J. Regulation of ankyrin-B-based targeting pathway following myocardial infarction. Cardiovasc Res. 2009;81:742-9.
- Thiel, W.H., Chen, B., Hund, T.J., Koval, O.M., Purohit, A., Song, L.S., Mohler, P.J., and Anderson, M.E. Proarrhythmic defects in Timothy Syndrome require calmodulin kinase II. Circulation. 2008;118:2225-2234.
- Le Scouarnec, S., Bhasin, N., Vieyres, C., Hund, T.J., Cunha, S.R., Koval, O., Marionneau, C., Chen, B., Wu, Y., Demolombe, S., Song, L.S., Le Marec, H., Probst, V., Schott, J.J., Anderson, M.E., and Mohler, P.J. Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease. Proc Natl Acad Sci.,USA. 2008;105:15617-22.
- Hund, T.J., Decker, K.F., Kanter, E., Mohler, P.J., Boyden, P.A., Schuessler, R.B., Yamada, K.A., Rudy, Y.. Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling. J Mol Cell Cardiol. 2008;45:420-8.
- Lowe, J.S., Palygin, O., Bhasin, N., Hund, T.J., Boyden, P.A., Shibata, E., Anderson, M.E., and Mohler, P.J. Voltage-gated Nav channel targeting in heart requires an ankyrin-G-dependent pathway. J Cell Biol. 2008;180:173-186.
- Hund, T.J., Lerner, D.L., Yamada, K.A., Schuessler, R.B., and Saffitz, J.E. Protein kinase Cε mediates salutary effects on electrical coupling induced by ischemic preconditioning. Heart Rhythm. 2007;4:1183-93
- Hund, T.J. and Rudy, Y. Rate dependence and regulation of the action potential and calcium transient in a canine cardiac ventricular cell model. Circulation. 2004; 110:3168-3174.
- Hund, T.J., Otani, N.F., Kucera, J.P., and Rudy, Y. Ionic charge conservation and long-term steady state in the Luo-Rudy dynamic model of the cardiac cell. Biophys J. 2001; 81:3324-31.