Department of Internal Medicine
Cardiovascular Medicine Faculty
Medical School:
The University of Iowa
Residency:
University of Texas,
Southwestern
Fellowship:
The University of Iowa
Peter Snyder, M.D.
Professor of Medicine and Molecular Physiology and Biophysics
Dr. Snyder's clinical interest is general cardiology. His research interest is understanding function and regulation of the DEG/ENaC family of ion channels. Defects in those channels cause hypertension and contribute to the pathogenesis of cystic fibrosis.
Honors, Awards, and Organizations
- Alpha Omega Alpha
- Astra-Merck Young Investigator Award, 1998
- American Heart Association Katz Basic Science Research Prize for Young Investigators, 1998
- American Society for Clinical Investigation, 2002
- Gill Heart Institute Young Physician Scientist Award, 2002
- American Society of Hypertension Young Scholar Award, 2003
- Association of University Cardiologists, 2003
Recent Publications
- Snyder PM. Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2. Sci Signal. 2009 Jul 14;2(79):pe41.
- Collier, D.M., and Snyder, P.M.: Extracellular Protons Regulate Human ENaC by Modulating Na+ Self-inhibition. J. Biol. Chem., 284(2):792-8, 2009.
- Kabra, R., Knight, K.K., Zhou, R., and Snyder, P.M.: Nedd4-2 Induces Endocytosis and Degradation of Proteolytically Cleaved Epithelial Na+ Channels. J. Biol. Chem., 283:6033-6039, 2008.
- Knight, K.K., Wentzlaff, D.M., and Snyder, P.M.: Intracellular Sodium Regulates Proteolytic Activation of the Epithelial Sodium Channel. J. Biol. Chem., 283(41):27477-82, 2008.
- Zhou, R., Patel, S.V., and Snyder, P.M.: Nedd4-2 Catalyzes Ubiquitihation and Degradation of Cell Surface ENaC. J. Biol. Chem., 282:20207-20212, 2007.
- Knight, K.K., Olson, D.R., Zhou, R., and Snyder, P.M.: Liddle's Syndrome Mutations Increase Na+ Transport Through Dual Effects on Epithelial Na+ Channel Surface Expression and Proteolytic Cleavage. Proc. Nat'l. Acad. Sci. U.S.A>, 103:2805-2808, 2006.
- Zhou, R. and Snyder, P.M.: Nedd4-2 Phosphorylation Induces Serum and Glucocorticoid-Regulated Kinase (SGK) Ubiquitination and Degradation. J. Biol. Chem., 280:4518-4523, 2005.
- Snyder, P.M.: Regulation of Epithelial Na+ Channel Trafficking. Endocrinology, 106:5079-5085, 2005.
- Snyder, P.M., Olson, D.R., Kabra, R., Ahou, R., Steines, J.C.: cAMP and Serum and Glucocorticoid-Regulated Kinase (SGK) Regulate the Epithelial Na(+) Channel Through Convergent Phosphorylation of Nedd4-2. J. Biol. Chem., 279:45753-45758, 2004.
Links of Interest