Department of Internal Medicine
Cardiovascular Medicine Faculty
Graduate School:
Physiology, Louisiana State
University Medical Center
Mark W. Chapleau, Ph.D.
Professor
Dr. Chapleau's research focuses on mechanisms of baroreceptor activation and factors determining sympathetic nerve activity in normal and pathologic states including hypertension, atherosclerosis and aging. Experimental approaches include studies in genetically modified mice and gene transfer using viral vectors.
Honors, Awards, and Organizations
- American Association of the Advancement of Science
- American Federation for Medical Research
- American Heart Association
- Council on Basic Cardiovascular Sciences, Fellow
- Council for High Blood Pressure Research, Fellow
- American Physiological Society, Cardiovascular Section, Fellow
- Inter-American Society of Hypertension (IASH)
- International Society for Autonomic Neuroscience (ISAN)
- Iowa Academy of Science
- Iowa Physiological Society (IPS)
- New York Academy of Sciences
- Society for Neuroscience
- NIH, FIRST Award, 1988-91
- VA Merit Review Awards, 1988-91, 1991-95, 1995-99, 1999-2004
- Editorial Board, Hypertension, 1991-1995, 2001-2004
- Editorial Board, Primary Sensory Neuron, 1995-1998
- Editorial Board, American Journal of Physiology (Heart and Circulatory Physiology), 1999-2000
- Editorial Board, American Journal of Physiology (Regulatory, Integrative, and Comparative Physiology), 2001-2006
- Editorial Board, Clinical Autonomic Research, 2001-2004
- Editorial Board, Current Hypertension Reviews, 2004-
Recent Publications
- Ma, X., Sigmund, C.D., Hingtgen, S.D., Tian, X., Davisson, R.L., Abboud, F.M., Chapleau, M.W.: Ganglionic Action of Angiotensin Contributes to Sympathetic Activity in Renin-Angiotensinogen Transgenic Mice. Hypertension 2[part2]: 312-316, 2004.
- Meyrelles, S.S., Sharma, R.V., Mao, H.Z., Abboud, F.M., Chapleau, M.W.: Modulation of Baroreceptor Activity by Gene Transfer of Nitric Oxide Synthase to Carotid Sinus Adventitia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284: R1190-R1198, 2003.
- Ma, X., Abboud, F.M., Chapleau, M.W.: Neurocardiovascular Regulation in Mice: Experimental Approaches and Novel Findings. Clin. Exp. Pharmacol. Physiol. 30: 885-893, 2003.
- Chapleau MW: Determinants of Baroreflex Sensitivity in Health and Disease: From Correlates to Causality. Clin. Auton. Res. 13:310-313, 2003.
- Snitsarev, V., Whiteis, C.A., Abboud, F.M. and Chapleau, M.W.: Mechanosensory Transduction of Vagal and Baroreceptor Afferents Revealed by Study of Isolated Nodose Neurons in Culture. Autonomic Neuroscience: Basic & Clinical 98:59-63, 2002.
- Ma, X., Abboud, F.M., and Chapleau, M.W.: Analysis of Afferent, Central and Efferent Components of the Baroreflex in Mice. Am. J. Physiol. Regulatory Integrative Comp. Physiol., 283: R1033-R1040, 2002.
- Chapleau, M.W., Li, Z., Meyrelles, S.S., Ma, X., and Abboud, F.M. Mechanisms Determining Sensitivity of Baroreceptor Afferents in Health and Disease. In: Neuro-Cardiovascular Regulation: From Molecules to Man. Ann. NY Acad. Sci., M.W. Chapleau, F.M. Abboud, eds. The New York Academy of Sciences, New York, NY, vol. 940, pp. 1-19, 2001.
- Ma, X.Y., Abboud, F.M. and Chapleau, M.W.: A Novel Effect of Angiotensin on Renal Sympathetic Nerve Activity in Mice. J. Hypertension 19:609-618, 2001.
- Fazan, R. Jr., Whiteis C.A., Chapleau, M.W., Abboud, F.M., and Bielefeldt, K.: Slow Inactivation of Sodium Currents in the Rat Nodose Neurons. Autonomic Neurosci.: Basic & Clinical 87:209-216, 2001.
- Ma, X.Y., Chapleau, M.W., Whiteis, C.A. Abboud, F.M. and Bielefeldt, K.: Angiotensin Selectively Activates a Subpopulation of Postganglionic Sympathetic Neurons in Mice. Circ. Res. 88:787-793, 2001.
Links of Interest