Department of Internal Medicine

Cardiovascular Medicine Faculty

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Mark E. Anderson, M.D., Ph.D.
Professor of Medicine and Physiology
Head, Department of Internal Medicine
Director, UI Cardiovascular Research Center

Dr. Anderson is clinically trained as a cardiac electrophysiologist. His research is focused on cellular signaling and ionic mechanisms that cause heart failure and sudden cardiac death. Work from the Anderson laboratory led to current concepts about the role of the multifunctional Ca2+/calmodulin dependent protein kinase II (CaMKII) as a central signal contributing to myocardial dysfunction and arrhythmias. The laboratory work ranges from molecular structure activity analysis of CaMKII to systems physiology using genetically modified mice. The main research themes pursued by the Anderson laboratory are 1. Oxidative activation of CaMKII; 2. CaMKII signaling to ion channels; 3. The role of CaMKII in inflammation; 4. The role of CaMKII in cardiac pacemaker cells; 5. The role of CaMKII in cell survival.

Links of Interest

• Dr. Anderson's Lab
• Transatlantic CaMKII Alliance website (Fondation Leducq)

Honors, Awards, and Organizations

• American Society of Clinical Investigation
• Established Investigator, American Heart Association
• Association of American Physicians
• Director, Fondation Leducq Transatlantic Network, “Alliance for CaMKII signaling”

Recent Publications

1. Joiner MA, Koval OM, Li J, He BJ, Allamargot C, Guo Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, Sivitz W, Song L-S, and Anderson ME. CaMKII determines mitochondrial stress responses in heart. Nature 2012 Nov 8;491(7423):269-73. doi: 10.1038/nature11444. Epub 2012 Oct 10. [PMID:23051746]
2. He BJ, Joiner MA, Singh MV, Luczak E, Dominic Swaminathan P, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, Blankesteijn WM, Heymans S, Mohler PJ, and Anderson ME. Oxidation of CaMKII determines cardiotoxic effects of aldosterone. Nat Med 17(12): 1610-1619, 2011. [PMID:22081025]
3. Swaminathan PD, Purohit A, Soni S, Voigt N, Singh M, Glukhov A, Gao Z, He J, Luczak E, Joiner M, Kutschke W, Yang J, Donahue JK, Weiss R, Grumbach I, Ogawa M, Chen P-S, Efimov IR, Dobrev D, Mohler P, Hund T, Anderson ME . Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest 121(8):3277-88, 2011. Commentary in J Clin Invest 121(8):2975-7, 2011. [PMID: 21785215]
4. Koval OM, Guan X, Wu Y, Joiner M, Gao Z, Chen B, Grumbach IM, Luczak ED, Colbran R, Song LS, Hund TJ, Mohler P, Anderson ME. The CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations. Proc. Natl. Acad. Sci. 107(11):4996-5000, 2010. [PMID: 20194790]
5. Wu Y, Gao Z, Chen B, Koval O, Singh M, Guan X,Hund T, Kutschke WJ, Sarma S, Grumbach I, Wehrens X, Mohler P, Song L, Anderson M.E. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc. Natl. Acad. Sci. 106:5972-5977, 2009. Chosen as a “From the Cover” article in PNAS and with a Commentary in Sci Signaling, 2:ec130, 2009. [PMID:19276108 ]
6. Singh, MV, Kapoun, A, Higgins, L, Kutschke, W, Thurman, JM, Singh, M, Yang, J, Guan, X, Lowe, J, Weiss, RM, Zimmerman, K, Zhang, R, Yull, FE, Blackwell, TS, Mohler, PJ, Anderson, ME. Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J. Clin. Invest. 119(4):986-996, 2009. Commentary in Nat Med 15:375, 2009. [PMID:19273909]
7. Erickson JR, Joiner MA, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O’Donnell S, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham A-JL, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell 2008; 133:462-474. Published with accompanying editorial 133: 397-399; Commentaries in Nat Med, 14:612, 2008 and Science Signaling, 1:ec161, 2008. [PMID:18455987]
8. Zhang R, Khoo MSC, Wu Y, Dzhura I, Ni G, Vishnivetskaya TA, Grueter C, Madu EC, Gurevich VV, Colbran RJ, Anderson ME. Calmodulin kinase II inhibition protects against structural heart disease. Nature Med 2005; 11:409-417. Published with an accompanying editorial. Selected as a recommended citation by the Faculty of 1000 Biology. [PMID:15793582]

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