Department of Internal Medicine
Cardiovascular Medicine Faculty
Medical School:
The University of Iowa
Residency:
University of Texas
Southwestern Medical Center
Fellowship:
The University of Iowa
Francis J. Miller, Jr., M.D.
Associate Professor
Dr. Miller's clinical interests include cardiology inpatient services and diagnostic cardiac catheterization. His research is directed at understanding molecular and cellular mechanisms involved in redox-mediated signaling by NADPH oxidases in the pathophysiology of vascular disease.
Honors, Awards, and Organizations
- Board Certification, Internal Medicine
- Board Certification, Cardiovascular Diseases
- North American Vascular Biology Organization
- American Heart Association, Council on Arteriosclerosis, Thrombosis, and Vascular Biology; Council on Basic Cardiovascular Sciences
- Chair, Midwestern Section of American Federation for Medical Research, 2007-08
- Society for Free Radical Biology and Medicine 2012-
- Editorial Board, Arteriosclerosis, Thrombosis, and Vascular Biology, 2002-10
- Editorial Board, American Journal of Physiology, Heart and Circulatory Physiology, 1999-04
- Peer Review Committees for the NIH, AHA and VA
- Associate Editor, Cardiovascular Therapeutics, 2010-
- President, American Federation for Medical Research, 2010-11
- Federation of American Societies for Experimental Biology, Board of Directors 2011-
Recent Publications
- Miller FJ Jr, Chu X, Stanic B, Tian X, Sharma RV, Davisson RL, Lamb FS. A differential role for endocytosis in receptor-mediated activation of Nox1. Antioxid Redox Signal. 2010 Mar 1;12(5):583-93. PubMed PMID: 19737091; PubMed Central PMCID: PMC2861543.
- Stanic B, Katsuyama M, Miller FJ Jr. An Oxidized Extracellular Oxidation-Reduction State Increases Nox1 Expression and Proliferation in Vascular Smooth Muscle Cells Via Epidermal Growth Factor Receptor Activation. Arterioscler Thromb Vasc Biol. 2010: 30:2234-2241. PubMed PMID: 20814013.
- Chu X, Filali M, Stanic B, Takapoo M, Sheehan A, Bhalla R, Lamb FS, Miller FJ Jr. A Critical Role for ClC-3 in Smooth Muscle Activation and Neotintima Formation. Arterioscler Thromb Vasc Biol. 2011. Feb;31(2):345-51. PMID: 21071705.
- Sheehan AL, Carrell S, Johnson B, Stanic B, Banfi B, Miller Jr FJ. Role for Nox1 NADPH oxidase in atherosclerosis. Atherosclerosis. 2011 Jun;216(2):321-6. PMID: 21411092.
- Zimmerman MC, Takapoo M, Jagadeesha DK, Stanic B, Banfi B, Bhalla RC, Miller FJ Jr. Activation of NADPH Oxidase 1 Increases Intracellular Calcium and Migration of Smooth Muscle Cells. Hypertension, 2011, Sep;58(3):446-53. PMID: 21810651
- Takapoo M, Chamseddine AH, Bhalla RC, Miller FJ Jr. Glutathione Peroxidase-Deficient Smooth Muscle Cells Cause Paracrine Activation of Normal Smooth Muscle Cells via Cyclophilin A. Vascular Pharmacology, 2011, 55(5-6):143-8. PMID: 21782974
- Xu S, Shriver AS, Jagadeesha DK, Chamseddine AH, Szőcs K, Weintraub NL, Griendling KK, Bhalla RC, and Miller FJ Jr.. Increased expression of Nox1 in neointimal smooth muscle cells promotes activation of matrix metalloproteinase-9. J Vasc Research, 2011, 49(3):242-8. PMID:22433789.
- Jagadeesha DK, Takapoo M, Banfi B, Bhalla RC, and Miller FJ Jr. Nox1 Transactivation of Epidermal Growth Factor Receptor Promotes N-Cadherin Shedding and Smooth Muscle Cell Migration. Cardiovascular Research, 2012, 93(3):406-13. PMID: 22102727
- Stanic B, Pandey D, Fulton DJ, Miller FJ Jr. Increased epidermal growth factor-like ligands are associated with elevated vascular NADPH oxidase in a primate model of atherosclerosis. Arterioscler Thromb Vasc Biol, 2012 32(10):2452-602012. PMID 22879585.
Links of Interest