Department of Internal Medicine
Cardiovascular Medicine Faculty
Medical School:
The University of Iowa
Residency:
University of Texas
Southwestern Medical Center
Fellowship:
The University of Iowa
Francis J. Miller, Jr., M.D.
Associate Professor
Dr. Miller's clinical interests include cardiology inpatient services and diagnostic cardiac catheterization. His research is directed at understanding molecular and cellular mechanisms involved in redox-mediated signaling by NADPH oxidases in the pathophysiology of vascular disease.
Honors, Awards, and Organizations
- Board Certification, Internal Medicine
- Board Certification, Cardiovascular Diseases
- American Physiological Society, Cardiovascular Section
- North American Vascular Biology Organization
- American Heart Association, Council on Arteriosclerosis, Thrombosis, and Vascular Biology; Council on Basic Cardiovascular Sciences
- Central Society for Clinical Research
- Chair, Midwestern Section of American Federation for Medical Research, 2007-08
- Society for Free Radical Biology and Medicine
- Editorial Board, Arteriosclerosis, Thrombosis, and Vascular Biology, 2002-
- Editorial Board, American Journal of Physiology, Heart and Circulatory Physiology, 1999-04
- Peer Review Committees for the NIH, AHA and VA
Recent Publications
- Chamseddine, A.H., and Miller, F.J.: gp91phox contributes to NADPH oxidase activity in aortic fibroblasts, but not smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 285(6):H2284-2289, 2003.
- Thomas, M., Gavrila, D., McCormick, M.L., Miller, F.J. Jr., Daugherty, A., Cassis, L.A., Dellsperger, K.C., and Weintraub, N.L.: Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Circulation 114:404-413, 2006
- Miller, F.J. Jr., Filali M, Huss GJ, Stanic B, Chamseddine A, Barna TJ, and Lamb FS. Cytokine activation of NF-kB in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. Circulation Research, 101:663-671, 2007. Published with accompanying editorial.
- Roghair, R.D., Miller, F.J. Jr. Scholz, T.D, Lamb, F.S., and Segar, J.L. Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone. Pediatric Res; 63(4):370, 2008.
- Tannous P, Zhu H, Johnstone JL, Shelton JM, Miller FJ Jr., Rothemel BA, Hill JA. Intracellular Protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation, 117:3070-8, 2008.
- Jagadeesha DK, Miller, F.J. Jr., Bhalla RC. Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury. J Vascular Research. 46;109-18, 2008
Links of Interest