Department of Internal Medicine
David Elliott, M.D., Ph.D.
Professor and Division Director
Dr. Elliott's research interest focuses on the mechanisms that control inflammatory reactions. His studies include the liver granulomas that develop in murine schistosomiasis; the role of the neuropeptide somatostatin in the regulation of the granulomatous response; and soluble mediators released by granuloma cells that affect inflammatory responses. He employs the ELISA assays of lymphokine production, cellular cloning, Northern blot analysis of granuloma mRNA, reverse transcription PCR or granuloma lymphocyte mRNA, RNASE protection assays, and molecular cloning. His key interests are immunology, immunoregulation, granulomatous inflammation, schistosomiasis, and inflammatory bowel diseases, lymphokines, T cell receptor.
- Setiawan, T., Metwali, A., Blum, A.M., Ince MN, Urban, JF Jr, Elliott, D.E. and Weinstock, J.V. Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine.. Infection and Immunity 75:4655-63, 2007.
- Elliott DE, Metwali A, Leung J, Setiawan T, Blum AM, Ince MN, Bazzone LE, Stadecker MJ, Urban JF Jr, Weinstock JV. Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production. J Immunol 181:2414-9, 2008.
- Braus, N, and Elliott, DE. Advances in the Pathogenesis and Treatment of IBD. (In Press - Clinical Immunology), 2009 .
- Ince, M.N., Setiawan, T., Metwali, A., Blum, A., Urban, J.F. Jr., Flavell, R.A., Elliott, D.E., and Weinstock, J.V. Role of T Cell TGFb Signaling in the Induction of Intestinal Interleukin 10 Response and Helminthic Immune Modulation. (In Press – European J. Immunology), 2009 .
- Weinstock, JV., and Elliott, DE. Helminths and the IBD Hygiene Hypothesis. Inflammatory Bowel Diseases 15:128-33, 2009.