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Biomedical Engineering Research
Multi-modality investigation of lung cancer nodules
Jessica deRyk
The registration of multi-modality lung nodule datasets including; computed tomography, micro-computed tomography, large image microscope array (LIMA) and pathology. Development of a classification algorithm to determine the three dimensional structure and tissue content of the nodule. Analysis of the classification findings, with an emphasis on the determined distribution of tissues within the nodule and their representation in the different datasets.
Novel laser scanning confocal microscopy (LSCM) techniques for imaging lung structure and function
Eman Namati
- In vivo molecular imaging of lung cancer
- In vivo molecular imaging of emphysema
- Development of fluorescent biomarkers.
In vivo small animal micro computed tomography imaging
Eman Namati
- High resolution in vivo lung imaging using novel respiratory gating techniques.
- In vivo assessment of emphysema in mice.
- In vivo early detection of lung cancer in mice
Complete three-dimensional anatomic and morphometric description of inter-species mouse airways using multi-modal techniques
Jacqueline Thiesse
This project is in developing a three-dimensional description of the mouse airways through multi modal techniques. The images acquired from each modality will provide differing and complementary information, ultimately leading to a more complete description. Of particular importance is in mimicing as closely as possible the in vivo conditions for a more accurate representation. This leads to a normal model that can be compared against disease models.
Lab specific software
Zaid Tofic
- Updating and re-programming the large image microscope array (LIMA) automation software
- Testing and of the quantitative imaging workstation software (QIWS) software
Multi-modal structural and functional description and analyses of the pulmonary airway mucosa
Melissa Suter
Functional imaging of the pulmonary mucosa via macro-optical imaging techniques including; a color analysis system and a fluorescent bronchoscopy imaging system. Fusion of the function macro-optical imaging data with 3D structural information from computed tomography. In addition, shape from shading methods were employed to extract airway geometry from bronchoscope images alone.
Virtual reality for the understanding of medical images
Kamalini Lecamwasam
Investigation of the validity and benefits of presenting3D computed tomorgaphy datasets in a virtual reality environment. Methods were developed for converting traditions medical image data to 3D fly-through models for display in a virtual reality cave.
Manipulating large image datasets
Scott Bond
Preliminary investigation into the manipulation of large image datasets and 3D visualization techniques
Three-dimensional geometric modeling of pulmonary surfactant in an idealized alveolar sac - an evaluation
Lynne Burrow
The role of the pulmonary surfactant layer lining the alveolar surface was investigated in this study by developing a finite element model to simulate the effect of surfactant inside a geometric alveolar sac. This was generated as an extension of a previous model.
Non-contact temperature measurement system
Tarun Kakaday
The design of a near infra-red system for the acquisition of non-contact temperature measurement in bronchial airways
Shape descrptor
Eman Namati
A robust shape descriptor based on empty morphological skeleton subsets.
The Large Image Microscope Array
Eman Namati
The design and development of the Large Image Microscope Array (LIMA) which is novel sectioning and imaging system for the application of aquiring true color digital images of fixed whole organs.
Magnetic camera capsule
James Leader
The proof of concept and design proposal for a system capable of floating a wireless miniature camera through the tracheobroncial tree.
Three-dimensional geometrical alveolar sac model
Jessica deRyk
This project involved the construction of a three dimensional, geometric alveolar sac Finite Element Model through which stress distribution due to normal conditions could be compared with those resulting from emphysemic conditions.
Color analysis system
Martin Donnelley
Preliminary development of a color analysis software system for the analysis of color bronchoscopic images.
Spatial distribution of hip capsule structural and material properties
Rohan Edmonds-Wilson
Experimental determination of quantitative, structural and material properties of the hip capsule.
Bronchoscopy color system
Melissa Suter
Development of intermediate hardware to gain digital video feed of color bronchoscopy proceedures. Development of a distortion correction algorithm for bronchoscopy images.
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