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Department of Internal Medicine - Research
Iowa Cardiovascular Center
Program Project Grants
INTEGRATIVE NEUROBIOOLOGY OF CARDIOVASCULAR REGULATION (HL 14388)
This Program Project Grant, formerly titled "Regulation of the
Circulation in Pathological States," is under the direction of Dr. Francois Abboud,
Professor, Department of Internal Medicine, and Professor of Molecular Physiology and
Biophysics, as well as the Director of the Cardiovascular Center. Funding of this Program
Project Grant for the current 5-year period (January 1998 through December 2002) totally
approximately $10.8 million. This brings the total approved support for a period of
over 30 years period to $54.8 million. The grant involves approximately 20 scientists
from 7 different departments. The three major components of the work are: central mediation
of baroreflexes, endothelial-neural-vascular interactions, and reflex autonomic control
in selected physiologic and pathologic states. This is a productive Program Project
Grant in its 29 th year of funding, and has contributed substantially to cardiovascular
research.
CEREBRAL BLOOD VESSELS (NS 24621)
This program project grant, currently in its fifteenth year, was first funded in 1987 by the Neurological Institute of the National Institutes of Health, and was competitively renewed in 1997. The principal investigator is Dr. Frank Faraci, Professor of Medicine, Division of Cardiovascular Medicine. The major projects in this Program Project Grant address the basic mechanisms that regulate cerebral circulation and the choroid plexus. Studies include the influence of endothelium on cerebral vascular muscle and choroid plexus, responses to neurohumoral stimuli, mediators of vascular injury, and effects of chronic hypertension. The research team consists of 9 scientists from 3 departments. Funding for the fifteen-year period 1987-2002 totals more than $15 million (direct and indirect costs). The fourth competing renewal for this grant will be funded in March, 2002.
GENE THERAPY FOR CYSTIC FIBROSIS LUNG DISEASE (HL 51670)
Currently in the eighth year of a 10-year period, this program project grant is under the direction of Dr. Michael Welsh, Professor of Internal Medicine in the Pulmonary Division. The major components of this center include: gene transfer of airway epithelia: evaluation of the efficacy and safety of adenoviral vectors; gene transfer to humans with cystic fibrosis using an adenoviral vector; and assessment of the immune response to a vector designed for cystic fibrosis gene therapy. Nineteen investigators from 9 departments participate in this program which has been awarded a total of $10.9 million for the period, 1994-2004 (direct and indirect costs).
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