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The Adult Blood and Marrow Transplantation Program


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Glossary - H


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HCT: See Hematocrit

Hematocrit (HCT): A blood test the tells the percentage of red blood cells in the blood.

Hematologist: A doctor who specializes in the study of diseases of the blood.

Hematology: A medical specialty that focuses on diseases of the blood and blood-forming organs.

Hematopoiesis: The process where blood cells are produced, mature and become specific types of blood cells.

Hematopoietic Stem Cells: Blood forming stem cells capable of producing all the components of blood and marrow. These cells are capable of both replacing themselves and maturing to white blood cells, red blood cells, and platelets.

Hematuria: Blood in the urine.

Hemoglobin: The material in red blood cells that carries oxygen.

Hemorrhagic Cystitis: A condition where the bladder tissue is ulcerated, usually due to infection or the toxic effects of certain types of chemotherapy.

Hepafilters: Air filters that remove very small particles, including bacterial or fungal agents but not viruses, from the air.

Hepatitis: Inflammation of the liver. It may be caused by a variety of reasons, including viral infections, bacterial invasion and physical or chemical agents.

Hepatitis B: A type of hepatitis that is carried and passed on through the blood.

Heredity or Hereditary: Qualities or traits transferred through the genes from one generation to another.

Herpes Simplex: A viral infection that usually produces small, temporary, irritating and sometimes painful fluid-filled blisters on the skin and mucous membranes. Herpes simplex type I is responsible for cold sores most often on the lips or in the mouth while type II is responsible for genital (most often) sores.

Herpes Zoster: A virus, otherwise known as the chickenpox virus. When it recurs on a strip of skin in an adolescent or adult it is sometimes called shingles. The virus – previously dormant in a nerve root along side the spinal cord – inflames nerves and results in painful skin eruptions that follow the route of these underlying nerves.

Histocompatibility: The state of similarity between tissues of the donor and the patient (recipient). The level of histocompatability describes how well a patient and donor are matched. The major histocompatability determinants in humans are called human leukocyte antigens (HLA). The closer the match, the less likely the donated stem cells and the patient's body will react against each other (see GVHD.)

HLA: See Human Leukocyte Antigens

HLA Typing:The process used to determine a person's HLA.

Hodgkin’s Disease: A type of cancer that affects the lymph nodes which are a part of our body’s immune system. Hodgkin's disease is a type of lymphoma. This cancer occurs most frequently in young adults.

Hospice: A community organization of nurses, pharmacists and physicians that provides supportive care to meet the special needs of dying patients and their families.

HTLV: See Human T-Cell Lymphotropic Virus

Human Leukocyte Antigens (HLA): A series of antigens found on white blood cells and most other cells of the body that are used to determine tissue type. Your HLA allows your immune system to recognize self from non-self. When these proteins are the same for both donor and recipient, an allogeneic stem cell transplant is much more likely to be successful. In stem cell transplantation, the HLA antigens routinely typed for are HLA-A, B, and DR.

Human T-Cell Lymphotropic Virus (HTLV): A rare virus transmitted by cellular components of blood. Two forms of the virus have been identified, HTLV-I and HTLV-II. These viruses can be associated with liver disease and in some populations, an aggressive form of leukemia or lymphoma.

Hyperplasia: Excessive growth of normal cells, which increases the size of an organ. In some cases hyperplasia can become malignant or cancerous.