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Glossary - C


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Cancer Chemotherapy: Chemical substances or medications used to kill cancer cells.

Cancer: A term for diseases in which abnormal cells divide without control and fail to die in a normal fashion. Cancer cells can invade nearby tissues and can spread through the bloodstream and lymphatic system to other parts of the body.

Cancerous: Containing cancer cells.

Carcinoma In Situ: A cancer that is confined superficially to its site of origin and has not invaded deeper to other parts of the organ.

CAT Scan: This test combines x-ray and computer technologies to produce highly detailed cross sectional tissue views.

Catheter (intravenous): A tube that is placed in a blood vessel to provide a pathway for drug or nutrients. With proper care, catheters can stay in place for several weeks or months.

Cell: The basic unit of any living organism.

Cell Differentiation: The process during which young, immature (unspecialized) cells take on individual characteristics and reach their mature (specialized) form and function for a particular tissue or organ.

Cell Motility: The ability of a cell to move.

Cell Proliferation: Cell growth and cell division that results in an increased number of cells.

Cellular Adhesion: The close bonding to adjoining cell surfaces.

Central Nervous System: Also called CNS. The brain and spinal cord.

Central Venous Catheter: One of numerous types of intravenous catheters designed for long-term use in giving drugs and total intravenous nutrition and in withdrawing blood samples. The intravenous tubing is surgically implanted into a large vein in the neck or shoulder and extends to a large blood vessel near the heart.

Cervical Nodes: Lymph nodes in the neck.

Chemoprevention: The use of drugs in an attempt to prevent disease.

Chemotherapy: A treatment that destroys cancer cells with drugs. Selected forms of chemotherapy work by inducing the differentiation of the cancer cell to a mature normal cell.

Chromosome: Part of a cell that contains genetic information. Normally, we humans have 46 chromosomes that appear as a long thread inside our cells.

Chronic Lymphocytic Leukemia (CLL): CLL is a disorder where too many lymphocytes, a type of white blood cell, are produced. This disease results in the abnormal accumulation of lymphocytes in the marrow, the bloodstream and the lymphatic system. CLL always involves the bone marrow, frequently involves the lymph nodes and less often infiltrates the spleen.

Chronic Myelogenous Leukemia (CML): CML is a disorder where too many granulocytes or myeloid cells, a type of white blood cell, are produced. This disease results in the abnormal accumulation of these cells in the marrow and the bloodstream and often the spleen. CML may occur at any age in either sex. It is uncommon before 10 years of age, and occurs at an average age of 45.

Clinical Trial: A study that uses new treatments to care for patients. During clinical trials, more information is collected about new treatments, their risks, and how well they do or do not work. If clinical trials show that the new treatment is better than the treatment currently being used, the new treatment may become the "standard" treatment.

CLL: See Chronic Lymphocytic Leukemia

CML: See Chronic Myelogenous Leukemia

CMV: See Cytomegalovirus.

CNS (Central Nervous System): The brain and the spinal cord.

CNS Prophylaxis: Chemotherapy or radiation therapy that is given to the central nervous system (CNS). This is preventive treatment. It is given to kill cancer cells that may be in the brain and spinal cord, even though no cancer has been detected there.

Colony-Stimulating Factors: Substances that stimulate the production of blood cells. Treatment with colony-stimulating factors (CSF) can help the blood-forming tissue recover from the effects of chemotherapy and radiation therapy. Factors are now available for red and white blood cells and platelet recovery.

Combination Therapy: This treatment uses a combination of surgery, radiation therapy, or chemotherapy to treat cancer.

Conditioning: The process of preparing the patient to receive stem cells for transplant. This is often done through the use of chemotherapy and radiation therapy.

Consolidation Therapy: Chemotherapy which is given only after a cancer is in remission. It is given to increase the chances that the remission will be long-lasting.

Confirmatory Typing: A repeat tissue typing test to confirm the compatibility of a volunteer or related donor with a patient. To determine if the relative or volunteer is interested in proceeding with testing, they are contacted by a member of the donor center. Arrangements are then made by the donor center for the drawing and shipping of the blood sample. The blood sample is tissue typed using DNA technology and is tested for infectious diseases.

CT (or CAT) scan: A test that takes a series of detailed pictures of areas inside your body. The pictures are created by a computer linked to an x-ray machine. Also called computed tomography scan or computed axial tomography scan.

Cutaneous: Related to the skin.

Cyclophosphamide: A drug used for immunosuppression and destruction of cancer cells. A commonly used brand name is Cytoxan.

Cyclosporine: An immunosuppressive drug used to treat and prevent graft-versus-host disease.

Cyst: A sac or capsule filled with fluid.

Cytology: The examination of cells – often obtained by a fine-needle aspiration – under a microscope to look for abnormalities.

Cytomegalovirus (CMV): A viral infection that can cause serious illness in immunosuppressed patients. New drugs are now available for prevention and treatment.