To: Associate Professor of Clinical Medicine
Division: General Internal Medicine

Medical School
The University of Iowa

Graduate School
The University of Iowa

Residency
The University of Iowa

Fellowship
The University of Iowa

Faculty Appointment
University of Iowa, 2001-

Teaching

• Launched pilot project to introduce end of life care to M1 and M2 students as Hospice volunteers. This work was supported in part by a grant from the Council on Teaching. The results are published in the Journal of Palliative Medicine.
• Attended the Service Learning Institute in 2005, a training workshop for faculty interested
  in using the experience of community service to enhance their didactic goals.
• Designed and taught a course called “learning about living from the dying” to students
• Gives a lecture on Non-Pain Symptoms at the End of Life in the End of Life Curriculum for FCP IV on a yearly basis for the past 3 years. This year, Dr. Broderick also developed a new lecture in
  Hospice and Palliative Medicine.
• Nominated for FCP IV Teacher of the Year by second year students nominated me for FCP IV.
• Collaborates with Drs. Lobas and Rosenbaum for M2 segments "Giving Bad News" and "Death."
• Developed pilot Narcotic Teaching Team, the first systematic attempt to teach narcotic prescribing at this institution.
• Directs the Hospice and Palliative Care Physician Mentorship
• Mentor for Residents in the Continuity of Care Clinic (COC)

Scholarship/Professional Productivity

• Areas of research interest:
  • teaching end-of life care
  • efficacy of shared medical appointments

Clinical and Administrative Service

• Active participation in all aspects of divisional clinical programs
• Medical Director, Iowa City Hospice, 1997-2007
• Director of Palliative Medicine June, 2007-
  

Recent Publications

Shunkwiler, S.M., Broderick, A., Stansfield, R.B., Rosenbaum, M. Pilot of a Hospice-Based Elective to Learn Comfort with Dying Patients in Undergraduate Medical Education. J Palliative Med, 8(2):344-353, 2005.

To: Associate Professor of Medicine
Division: Gastroenterology and Hepatology

Medical School
Case Western Reserve University

Graduate School
London School of Economics

Residency
Case Western Reserve University
Cleveland Metropolitan General Hospital

Fellowship
University of Virginia

Faculty Appointment
St. Louis University, 1993-2001
The University of Iowa, 2001-

Teaching

• Teaches residents and fellows on the UIHC Liver Service, in clinic, during endoscopy sessions, and on the VA GI Service.
• Presents GI/Liver core conference and board review annually.
• Serves as research project mentor for residents and fellows.
• Liaison for the GI-Liver teaching in FCPIV. Dr. Brown lectures on metabolic, genetic and viral liver disease, conducts the review session, precepts for small group sessions and attends most of the other lectures.
• Runner-up for the FCP IV Teaching Award.
• Lectures on viral hepatitis for a College of Public Health course (Epidemiology of Infectious Diseases) annually.
• Invited speaker at the Annual GI Nurses Conference.
• Speaker, Iowa Physician Assistant Society CME conference.

Scholarship/Professional Productivity

• Areas of research interest:
• hepatic stellate cells (HSC) and liver fibrogenesis
• iron-liver interactions
• VA Merit Review grant: “The role of NADPH oxidases in the activation of hepatic stellate cells."
• Presented an oral presentation on proliferative effects of iron overload at the American Association for the Study of Liver Disease.
• Presented a poster at the AASLD showing increased hepatic telomerase activity in a rat model of iron overload.
• Collaborates with colleagues on both basic science and clinical research projects.

Clinical and Administrative Service

• Active participation in all aspects of divisional clinical programs
• Weekly liver clinic, full day of endoscopy each week, staffs the inpatient Liver Service at UIHC and GI service at the VA
• Director of Endoscopy, VAMC
• Manuscript reviewer for: Gastroenterology, Gut, Hepatology, American Journal of Pathology.
• Ph.D. Committee Member for Steve Bloomer, a PhD candidate in Exercise Science in Kevin Kregel’s lab, and Alix Ashare, PhD candidate in Translational Biomedicine.
• Director, GI Fellowship Program
• Committees: VA Research and Development Committee, VA Transfusion Committee
• Annual radio interview: Iowa Health Care Today, concerning hemochromatosis for Hemochromatosis Screening Awareness Month.

Recent Publications

Kyle E. Brown, Elizabeth M. Brunt, and Jay W. Heinecke. lmmunohistochemical detection of myeloperoxidase and its oxidation Products in Kupffer Cells of human liver.  American Joumal of Pathology (2001) 1159:2081-2088.

Kyle E. Brown, Kimberly A. Broadhurst, M. Meleah Mathahs, Elizabeth M. Brunt
and Warren N. Schmidt.  Expression of HSP47, a collagen-specific chaperone, in normal and diseased human liver.  Laboratory Investigation (2005) 85:789-797.

Brown, K.E., Dennery, P.A., Ridnour, L.A., Fimmel, C.J., Kladney, E.D., Brunt, R.M.,
Kyle E. Brown, M. Meleah Mathahs, Kimberly A. Broadhurst, and Jamie Weydert. Chronic iron overload stimulates hepatocyte proliferation and cyclin D1 expression in rodent liver.  Translational Research (2006) 148:55-62.

Kyle.E. Brown, M.Meleah. Mathahs, Kimberly A. Broadhurst, Mitchell C. Coleman, Lisa A. Ridnour, Douglas R. Spitz.  Increased telomerase activity in a rat model of iron overload: a role for altered thiol redox state?  Free Radical Biology and Medicine (2007) 42:228-235.

To: Associate Professor of Clinical Medicine
Division: General Internal Medicine

Medical School
University of Texas Southwestern

Residency
Duke University

Faculty Appointment
University of North Carolina, Chapel HIll, 1993-95
The University of Iowa, 2000-

To: Professor of Clinical Medicine
Division: Endocrinology and Metabolism

Medical School
University of Minnesota

Residency
University of Minnesota

Fellowship
Vanderbilt University

Faculty Appointment
Vanderbilt University, 1982-83
University of Wisconsin, 1987-2000
The University of Iowa, 2000-

Teaching

• Actively involved in the training of medical students, residents, and fellows on inpatient internal medicine wards at UIHC and the VAMC as well as the endocrinology and metabolism consult service.
• Actively involved in FCP IV, including small group sessions, the Clinician Mentor program, the endocrinology lecture series, case presentations, and exam questions submitted.
• Participates in Physical Exam Academy, as well as case presentations, tutorial guide, and 1 hour lecture on type 2 diabetes for FCP II.
• Presents at division conferences on a regular basis.
• Participates in the Iowa Basic Science Course in Otolaryngology
• Participates in the endocrinology board review course for internal medicine residents.
• Invited speaker, Endocrine Society 85th Annual Meeting in Philadelphia, Pennsylvania.
• Invited participant in the in the Head and Neck Cancer and Reconstruction Surgery Course sponsored by the Department of Otolaryngology.
• Coordinates the annual Joseph D. Brown Diabetes Conference

Scholarship/Professional Productivity

• Areas of Research Interest
  • Intensive insulin therapy
  • Diabetes mellitus and arteriosclerosis risk
• Participated in development of the Diabetes Disease Management Clinic in the Family Care Center.
• Participated in a UI Health Plans Performance Project: Evaluating Quality of Care Through Delta Tracking.
• Participating in the Diabetes Outcomes Taskforce
• Participate in UIHC committees working on standards and guidelines for perioperative diabetes management of patients under the care of the Cardiovascular and Thoracic Surgery service, and in developing guidelines for inpatient diabetes self-management.
• Worked to develop a web presence for "Diabetes Clinics and Services at the University of Iowa Hospitals and Clinics."
• Served as a consultant on grants submitted by Dr. William Doucette in the College of Pharmacy and Dr. Arthur Hartz in the Department of Family Medicine.
• Served as co-investigator on several clinical trials in the Lipid Research Clinic and am co-investigator on “ACCORD, Action to Control Cardiovascular Risk in Diabetes”.
• Principle investigator on an industry-sponsored trial entitled “ARISE: Aggressive Reduction of Inflammation Stops Events.”
• Investigator and consultant on a major NIH funded trial “Clinical Islet Transplantation: Data
  Coordinating Center.”
• Interview medical school applicants and applicants to the internal medicine residency program.
• Represent the Division of Endocrinology and Metabolism on the Clinical Leadership Council.

Clinical and Administrative Service

• Active participation in all aspects of divisional clinical programs.
• Diabetes Outcomes Task Force
• Participate in specialty clinics at the University of Iowa Hospitals and Clinics, including the diabetes clinic, endocrinology clinic, lipid clinic and insulin pump clinic, Endocrinology Head and Neck Tumor Clinic
• Participate regularly in endocrinology and diabetes clinics at the Veteran’s Affairs Medical Center and attend one outreach clinic each month in Burlington, Iowa.

Representative Publications

Doelle, GC: The Clinical Picture of Metabolic Syndrome. Postgraduate Medicine 116(1);30-38,2004.

Gudmundsdottir, A., Doelle, G.C.: Hypercalcemia and Hypocalcemia, In: Endocrine Disease: Early Diagnosis and Treatment, Bar, R.S., (ed.), Totowa, NJ, Humana Press, Inc., 2002.

Teaching:

• Mentoring residents and medical students in our general medicine primary care, acute care and consult clinics and on inpatient services.
• Volunteered to teach every course in the medical school’s Foundations of Clinical Practice series, mentoring small groups of medical students for a semester.
• Presented regional and national workshops, Internal Medicine and Psychiatry Grand Rounds, CME lectures for our regional ACP, Family Practice, Nurse Practitioner and Physician Assistant meetings, and continue to lecture to residents and medical students.
• Helped create curricula to introduce residents to evidence-based medicine, standardize our approach to perioperative risk assessment, and ensure coverage of important ambulatory care topics.
• Coordinate, schedule and teach the Internal Medicine Ambulatory Block Curriculum.
• Created and oversaw the General Medicine Consult Service Curriculum and taught the perioperative risk assessment component.
• Helped create an ambulatory care curriculum for our resident general medicine clinic.
• I developed interactive sessions on colon and prostate cancer screening and have lead the colon cancer discussions for the four Ambulatory Practice Modules for M3 students.
• Lecture on perioperative cardiac risk assessment as part of the residents’ board review sessions.
• Invited to give a joint injection and aspiration workshop for the University of Iowa physician assistant students.
• Co-presented (with Dr. Scott Vogelgesang) joint injection and aspiration workshops for the state-wide physician assistant and nurse practitioner conferences.
• Teaching Honors and Evaluations:
  • Nominated for a University of Iowa Collegiate Teaching Award, 1997
  • Nominated for the teacher of the year by internal medicine residents, 2000
  • Received the 2000 David E. Rogers award for my workshop “Controversies in DVT Prophylaxis: Orthopedic Hip and Knee Surgery” given in Boston at the national Society of General Internal Medicine (SGIM) meeting. This award is given to the top three workshops given by junior faculty.
  • Nominated for the SGIM Midwest Clinician Educator Award, 2000

Scholarship/Professional Productivity

• Contributed to the study design and edited the grant and paper for Mike Ernst’s clinical trial comparing the 24-hour effectiveness of hydrochlorothiazide and chlorthalidone. The paper was published in Hypertension this year.
• Reviewed the grant and served on the monitoring board for Barry Carter’s NIH-funded study entitled “Collaborative Management of Hypertension”.
• Volunteered to examine patients as part of University of Iowa Ophthalmology research studies since 1998.
• Restructured the resident primary care clinic to create teams of faculty, residents and nurses to improve patient care and continuity.
• Presented (with Dr. Gwen Beck) our new resident clinic model at the 2006 and 2007 national Society of General Internal Medicine (SGIM) meetings.

Clinical and Administrative Service

• Medical Director, General Medicine Clinic in the Family Care Center (FCC).
• Member of the FCC team participating in the statewide Chronic Care Improvement Learning Collaborative.
• Member of SGIM and SGIM’s Medical Residents Clinic Director’s interest group.
• Served on the review committee for the University of Iowa PA program in 2005.
• Received an Above and Beyond the Call of Duty award from a patient in 1999, FCC nurses in 2000 and  UIHC social workers in 2005.
• Interviews internal medicine resident applicants each year.
• Serves on the PA/ARNP sub panel to review the credentialing and privileging of these providers.
• Member of the Flock’s medical student community at the University of Iowa.
• Volunteer at the Iowa City Free Medical Clinic.

Recent Publications

Ernst, M., Carter, B., Goerdt, C., Stiffens, J., Phillips, B., Zimmerman, M., Bergus, G. Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure. Hypertension 47:352-358, 2006.

Teaching

• Participates in the FCP II Clinical Shadowing Program
• Mentors female premedical students through Medicus Premedical Society.
• Works with third and fourth year medical students and residents in Acute Care Clinic
• Prepared topics for the General Medicine Ambulatory Curriculum on Obstructive Sleep Apnea, Proteinuria, Allergic Rhinitis, Erectile Dysfunction, Infectious Mononucleosis/CMV, and Contact Dermatitis/ Seborrheic Dermatitis/Eczema.
• Facilitated a small group in FCP III Patient Centered Learning
• Assisted as a small group learning facilitator in the Health Promotion/Disease Prevention session for the Ambulatory Practice Module course, reviewing the pros and cons of prostate cancer screening
• Learning facilitator for FCP II: Physical Exam Skills, and FCP III: Physical Findings.
• Learning facilitator for FCP III, Human Sexuality.
• Facilitated a small group in FCP II, Case-Based Learning II.
• Participates in the Men’s Health Session for the Ambulatory Practice Module, with prepared talks and small group discussions on Erectile Dysfunction, Scrotal Pain, Scrotal Mass, Alcohol and Violence, and other topics.
• Participates in an Outpatient Continuity Elective of M4s and COC with residents.
• Case author for the FCP II: Case-Based Learning.

Scholarship/Professional Productivity

• Areas of research interest:
  • Gender Issues in Medicine
• Built a substantial faculty practice in the Family Care Center.
• Assisted in reviewing Essentials of Clinical Geriatrics and The Pharmacologic Basis of Therapeutics (Goodman and Gilman) for McGraw Hill Publishing.
• Reviewed vignette abstracts for the 2004 Midwest Regional SGIM meeting.
• Submitted a workshop entitled, “Couples in Medicine: ‘Stress is Inevitable. Struggling is Optional,’” to the 2003 Midwest Regional SGIM meeting in Chicago.
• Invited speaker, VA Women’s Health Fair in, Bettendorf, Iowa, on “Heart Disease in Women.”
• Presented to our division in November of 2003 on “Gender Issues in Medicine: An Overview."
• Developed, “A Study of Gender and Factors Associated with Faculty Career Satisfaction,” an anonymous survey which was sent to all University of Iowa Carver College of Medicine faculty (N ≈ 815), requesting their perceptions regarding various dimensions of their university work life.

Clinical and Administrative Service

• Regularly meets with new faculty and fellowship recruits
• Assisted with the College of Medicine’s admissions interview process
• Participated in Internal Medicine Residency interviews.
• Receive the Above and Beyond the Call of Duty Award from a nurse in the Call Center, after observing my care and concern for a patient. (2001)
• Attended Departmental, Division, and Family Care Center meetings and contributed my thoughts and insights.
• Participated in two focus groups: one exploring interprofessional relationships between primary care physicians and chiropractors, and the other discussing the beliefs and values that motivate physicians to disclose their own medical errors.
• Internal Medicine physician representative for the Family Care Center Quality and Performance Improvement Committee (2003-2004).
• Founding member and co-chair of the University of Iowa Women in Medicine and Science program.
• Serve as one of only five University-wide faculty representatives to the Council on the Status of Women (2003-06)
• Member of the subcommittee for Faculty Recruitment and Retention, and Co-chair of the Jean Y. Jew Women’s Rights Award subcommittee.
• Asked to serve on a College of Medicine committee formed to address the recent findings summarized in the recent University-wide Report of the Gender Equity Task Force.

Recent Publications

to be added

Teaching:

• Teaches students, residents, fellows and pharmacy students on the inpatient medicine, or hospitalist service, at UIHC and Iowa City VA.
• Teaches three lectures during FCP-I in evidence based medicine (EBM) and biostatistics and one FCP-IV lecture on pneumonia
• Facilitated a Case-Based-Learning group for FCP-IV.
• Assistant Residency Program Director (2002-03)
• Facilitated resident noon conferences, Morbidity, Mortality, and Improvement conference, resident board review sessions, physical diagnosis rounds, and lectures on VTE for the departments of orthopedics, surgery, and neurosurgery.
• Taught summer course in biostatistics for the K-30 program in clinical investigation
• Published work in VTE in Clinics of North America (2003) and Just the Facts in Perioperative Medicine (2006) has been used in the peri-operative consultation curriculum.

Scholarship/Professional Productivity

• Recently completed two studies: the VA-funded “Randomized Controlled Trial of Enhanced Pharmacy Care in Older Veteran Outpatients” and the AHRQ-funded “Multi-Center Trial of Academic Hospitalists.”
• Authored or co-authored 47 peer-reviewed abstracts that have been presented at regional, national, and international meetings, many of which are manuscripts in preparation.
• Participated in multi-institutional collaborations.
• Published four book chapters, two of which are updated annually on the widely used on-line clinical resources, UpToDate and the American College of Physicians PIER resource.
• Authored two invited editorials.
• VA Research Career Development Award (1/04-12/06), “Improving Medication Prescribing, Delivery, and Effectiveness in Veterans.”
• VA Merit grant, “Implementing Evidence-Based Treatment of Hypertension” (7/05-6/08; $884,300)
• Submitted my second VA HSR&D Merit grant, entitled “Impact of Hospitalists on Hospitalized Medical Patients in VHA.”
• Developed collaborative relationships both within UI and externally.
• Co-investigator on five recent VA and NIH grant submissions:
  • “Patient and Provider Attitudes in the Healthcare Context” (VA HSR&D Merit Review Grant) with Alan Christensen, PhD (Department of Psychology)
  • “Pharmacist Continuity of Care” (NHLBI) with Barry Carter, PharmD (College of Pharmacy)
  • “Low Literacy Intervention to Improve Medication and Appointment Adherence” (NIH R01) with Ahsan Arozullah MD at the University of Illinois-Chicago
  • “Development and Validation of Disease Specific Health Literacy Measures” (VA HSR&D) with Dr. Arozullah
  • “Guideline Adherence in Elders with Heart Failure and Multiple Comorbidities” (VA HSR&D) with Michael Steinman MD at UCSF.

Clinical and Administrative Service

• Chair the UIHC Diagnostic Services Subcommittee
• Serve on the UIHC Pharmacy and Therapeutics, Medication Safety, and Medication Use Evaluation Subcommittees
• Appointed to the VA VISN 23 Formulary Committee.
• Served on the Department Search Committee for the Gastroenterology Division Chief and co-chaired the Department Research Day.
• Served as a mentor to Kent Ray, General Medicine Fellow 2004-06.
• Member of doctoral committee for Jamie Cvengros, PhD candidate in the Department of Psychology.
• Participated in the MSTP Clinical Connections program annually; facilitated the MSTP student Patient-Based Learning (PBL) group (2005 and 2006)
• Ad hoc reviewer for eight journals, including JAMA and the Annals of Internal Medicine.
• Appointed an ad hoc member of the VA HSR&D Scientific Review Board (i.e., “study section”) in Implementation Science and was recently appointed as a new 3-year member.
• Established regional and national recognition in the Society of General Internal Medicine (SGIM) and Society of Hospital Medicine (SHM).
• Served on the Midwest Regional SGIM Council from 2002-2005 and was a member of the 2005 SGIM Annual Meeting Committee.
• Review research abstracts for the SGIM Annual Meeting, as well as the VA HSR&D Annual Meeting.
• Participant in the UIHC hospitalist group since its inception in 2000 and the results of our first year of service were published in the American Journal of Managed Care in August 2004.
• Charter Member of the Society of Hospital Medicine (SHM) and at the annual meeting have presented abstracts, chair the Research Interest Group, and chaired the Abstract Review Committee.
• Appointed the Chair of the Hospitalist Field Advisory Committee for VA Central Office.
  
• Medical director of the UIHC Anticoagulation Case Management Service (ACMS).
• Presented at the Society of General Internal Medicine (SGIM) Annual Meeting Thrombosis Interest Group and have spoken locally and nationally on VTE prophylaxis.
• Invited speaker at the University Health System Consortium (UHC) annual meeting in 2003.

Recent Publications

Hoth, A.B., Carter, B.L., Ness, J., Bhattacharyya, A., Schorr, R.I., Rosenthal, G.E., Kaboli, P.J.  Development and Reliability Testing of the Clinical Pharmacist Recommendation Taxonomy. Pharmacotherapy 2007; 27(5): 639-646.

Steinman, M.A., Landefeld, C.S., Rosenthal, G.E., Berthenthal, D., Kaboli, P.J. Conflicts and Concordance Between Measures of Medication Prescribing Quality. Med Care 2007 (Jan); 45(1): 95-99.

Kaboli, P.J., Shivapour, D.M., Henderson, M.S., Barnett, M.J., Ishani, A., Carter, B.L. Patient and Provider Perceptions of Hypertension Treatment: Do They Agree?  J Clin Hypertens 2007 (June); 19(6):416-423.

Mark Karwal, M.D.

Teaching

• Teaches students, residents, and fellows in clinic
• Teaches fellows, students, and residents in the tumor boards for breast cancer, GI cancers, and general surgery conferences.
• Teaches in the continuing education programs, giving lectures in Iowa and across the
  country.
• Presented an update on Breast Cancer for the Surgical CME program several times over the past few years.

Scholarship/Professional Productivity

• Areas of research interest:
• Breast Cancer
• Major investigator for the Dept of Internal Medicine in the NSABP.
• Principal investigator for 7 industry sponsored trials, including a trial of Epothilone B for breast cancer, Taxotere and Xeloda versus Taxotere and Gemcitabine for metastatic breast cancer, healing touch as a supportive care for breast cancer patients, a phase III trial of a novel agent for hepatocellular cancer called Thymitaq.

Clinical and Administrative Service

• Central medical oncologist for the management of breast cancer at the University of Iowa, working closely with the general surgery service.
• Developed the multidisciplinary breast cancer tumor board
• Works with the transplant service to maintain a state of the art program for patients with hepatic cancers, both primary and metastatic to the liver.
• Monthly outreach to Fort Madison providing the only medical oncology care in the community.

Recent Publications

Bushnell, D., Menda, Y., O’Dorisio, T., Madsen, M., Miller, S., Carlisle, T., Squires, S., Kahn, D., Walkner, W., Connolly, M., O’dorisio, S., Karwal, M., Ponto, J., Bouterfa, H. Effects of intravenous amino acid administration with Y-90 DOTA-Phe 1-Tyr3-Octreotide (SMT487[OctreoTher) treatment. Cancer Biother Radiopharm. 2004 Feb; 19(1):35-41.

Dahl, K.A., Kernstine, K.H., Vannatta, T.L., Karwal, M.W., Thomas, K.W., Schraith, D.F. Tracheobronchial amyloidosis: a surgical disease with long-term consequences. J Thorac Cardiovasc Surg. 2004 Nov; 128(5):789-92.

To: Professor of Medicine
Division: Pulmonary, Critical Care and Occupational Medicine

Medical School
University of Missouri, Kansas City

Residency
University of Colorado

Fellowship
Washington University, St. Louis

Faculty Appointment
Washington University, 1995-2001
University of Iowa, 2001-

To: Professor of Clinical Medicine
Division: General Internal Medicine

Medical School
Universidade Federal de Pernambuco

Residency
Hospital Central do IASERJ
The University of Iowa

Fellowship
The University of Iowa

Faculty Appointment
University of Iowa, 1995-

To: Professor of Medicine
Division: Gastroenterology and Hepatology

Graduate School
University of Illinois

Medical School
University of Tennessee

Residency
University of Tennessee

Fellowship
The University of Iowa

Faculty Appointment
University of Iowa, 1995-

To: Associate Professor of Clinical Medicine
Division: Nephrology

Medical School
St. Louis University

Residency
Mayo Graduate School of Medicine, Rochester

Fellowship
The University of Iowa

Faculty Appointment
University of Iowa, 1996-