Dr. Kashiwada's research focuses on understanding the molecular mechanisms of lymphocyte activation, development, and differentiation by signaling molecules specifically expressed in hematopoietic cells.

Recent Publications

1. Kashiwada, M., McKeag, L., Showalter, B.M., Cattoretti, G., Al-Alem, U., Niki, M., Pandolfi, P.P., and Rothman, P.B.  Dok-1 and SHIP are required for normal T cell development. (Submitted).
2. Kashiwada, M., Giallourakis, C.C., Pan, P.Y. and Rothman, P.B. Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation. (2001) J Immunol., 167, 6382-6387.
3. Jiang, H., Foltenyi, K., Kashiwada, M., Donahue, L., Vuong, B., Hehn, B., and Rothman, P. Fes mediates the IL-4 activation of insulin receptor substrate-2 and cellular proliferation. (2001) J. Immunol., 166, 2627-2634.
4. Cox, D., Dale, B.M., Kashiwada, M., Helgason, C.D. and Greenberg, S. A regulatory role for Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) in phagocytosis mediated by Fc gamma receptors and complement receptor 3 (alpha(M)beta(2); CD11b/CD18). J. Exp. Med., 193, 61-71, 2001.
5. Giallourakis, C., Kashiwada, M., Pan, P.Y., Danial, N., Jiang, H., Cambier, J., Coggeshall, K. M. And Rothman, P. Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase. J. Biol. Chem., 275, 29275-29282, 2000.

Graduate School:
University of Tokyo

Postdoctoral Training:
Columbia University