Department of Internal Medicine
Rheumatology Faculty
John S. Cowdery, M.D.
Professor
Chief of Staff, Iowa City VAMC
Associate Dean for Veterans' Affairs
Dr. Cowdery's research interests include Laboratory research focuses the molecular mechanisms by which CpG DNA activates the inflammatory response (including the production of cytokines such as IL-12 and TNF-alpha) in macrophages. Current work addresses the proximal events in the recognition of CpG DNA by the receptor TLR9. Using macrophages that are stably transfected with epitope-tagged TLR9, we are attempting to dissect the molecular requirements for TLR9 binding of CpG DNA. As Chief of Staff at the Iowa City VAHCS, I am committed to the application of evidence-based clinical practices in all arenas of clinical service. I strongly support hypothesis-driven clinical initiatives that have the potential to expand our base of evidence-based medicine. His clinical interests include the use of immunomodulating agents in the treatment of rheumatic diseases, and the treatment of vasculitis.
Honors, Awards, and Organizations
- American Association of Immunologists
- Diplomate, American Board of Internal Medicine and Board of Rheumatology
- American Federation for Medical Research
- Central Society for Clinical Investigation
- Immunology Virology Pathology Study Section (NIH)
- Editorial Board, Journal of Musculoskeletal Medicine
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Medical School:
Emory University
Residency:
Emory University
The University of Iowa
Fellowship:
Arthritis Branch, NIH |
Recent Publications
- Cowdery, J.S., Chace, J.H., Yi, A.K., and Krieg, A.M.: Bacterial DNA Induces NK Cells to Produce Interferon-gamma InVivo and Increases the Toxicity of Lipopolysaccharide. J. Immunol., 156 :4570, 1996.
- Chace, J.H., Hooker, N.A., Mildenstein, K.L., Krieg, A.M., and Cowdery, J.S.: Bacterial DNA Induced NK Cell IFN- g Production is Dependent on Macrophage Secretion of IL-12. Clin.Immunol. Immunopathol., Vol 84, August, pp. 185-93, 1997.
- Cowdery, J.S., Boertz, N.J, Norian, L.A., Myung, P.S., and Koretzky, G.A.: Differential regulation of the IL-12 p40 promoter by CpG DNA and lipopolysaccharide. J. Immunol., 162:6770-75, 1999.
- Bradford M.A., Schroeder A.J., Morse H.C., Vogel S.N., and Cowdery J.S. CpG DNA-induced IL-12 p40 gene activation is independent of STAT1 activation or production of interferon consensus sequence binding protein. J. Biomed Sci, 9:688-696, 2002.
Links of Interest
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