Department of Internal Medicine
Rheumatology Faculty
Graduate School:
Cellular and Molecular Biology, University of Michigan
Fellowship:
University of North Carolina
Gail Bishop, Ph.D.
Holden Chair in Cancer Biology
Professor of Microbiology & Internal Medicine
Assoc. Director for Basic Science Research,
Holden Comprehensive Cancer Center
Director, Graduate Program in Immunology
Dr. Bishop's research investigates molecular mechanisms of lymphocyte activation and tolerance, in normal and malignant B cells.
Honors, Awards, and Organizations
- American Association of Immunologists
- American Society for Microbiology
- American Society for Biochemistry & Molecular Biology
- University of Michigan Rackham Fellowship, 1982-1983
- Damon Runyon Cancer Fund Fellow, 1984-1986
- National Arthritis Investigator Award, 1987-1990
- Carver Foundation Faculty Fellow, 1994-1997
- College of Medicine Endowed Chair in Medicine & Microbiology, 2001
- Donald Dorfman Lymphoma Research Award, 2003
- Graduate College Outstanding Mentor Award, 2003
Recent Publications
- Hostager, B.S., Haxhinasto, S.A., Rowland, S. and Bishop, G.A. TRAF2-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J. Biol. Chem.278:45382-45390, 2003.
- Haxhinasto, S.A. and Bishop, G.A. Synergistic B cell activation by CD40 and the B cell antigen receptor: Role of BCR-mediated kinase activation and TRAF regulation. J. Biol. Chem.279:2575-2582, 2004.
- Xie, P., Hostager, B.S. and Bishop, G.A. Requirement for TRAF3 in signaling by the EBV-encoded oncoprotein LMP1, but not CD40, in B lymphocytes. J. Exp. Med. 199:661-671, 2004.
- Stunz, L.L., Busch, L.K., Munroe, M.E., Sigmund, C.D., Tygrett, L.T., Waldschmidt, T.J., and Bishop, G.A. Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. Immunity 21:255-266, 2004.
- Hostager, B.S. and Bishop, G.A. Role of TRAF2 in the activation of IgM secretion by CD40 and CD120b. J. Immunol. 168:3318-3322, 2002.
- Brown, K.D., Hostager, B.S. and Bishop, G.A. Regulation of TRAF2 signaling by self-induced degradation. J. Biol. Chem., 277:19433-19438, 2002.
- Haxhinasto, S.A., Hostager, B.S. and Bishop, G.A. Cutting Edge : Molecular mechanisms of synergy in signaling to B cells by CD40 and the BCR: Role for TRAF2 in receptor interaction. J. Immunol. 169:1145-1150, 2002.
- Bishop, G.A., Hostager, B.S. and Brown, K.D. " Mechanisms of tumor necrosis factor receptor associated factor (TRAF) regulation in B lymphocytes", J. Leuk. Biol. 72:19-23, 2002.
- Bishop, G.A. and Busch, L.K. "Molecular mechanisms of B lymphocyte transformation by Epstein-Barr virus", Microbes & Infection 4:853-857, 2002.
- Baccam, M., Woo, S.-Y., Vinson, C. and Bishop, G.A. CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: Involvement of NF-kB, AP-1, and C/EBP. J. Immunol. 170:3099-3108, 2003.
- Haxhinasto, S.A. and Bishop, G.A. A novel interaction between PKD and TRAFs regulates BCR-CD40 synergy. J. Immunol. 171:4655-4662, 2003.
- Bishop, G.A. and Hostager, B.S. "The CD40-CD154 interaction in B cell-T cell liaisons". Cytokine & Growth Factor Reviews 14:297-309, 2003.
- Bishop, G.A., Haxhinasto, S., Stunz, L., and Hostager, B.S. "Antigen-specific, T-dependent B cell activation". CRC Critical Reviews in Immunology 23:149-198, 2003.
- Bishop, G.A. and Hostager, B.S. "Signaling complexes of TNF-receptor family molecules", Chapter 56, Handbook of Cellular Signaling, R. Bradshaw & E. Dennis, Eds., Elsevier Science, 2003.
- Bishop, G.A. "TRAF regulation of B lymphocyte function", invited review for Nature Immunology, in press, 2004.
Links of Interest