Department of Internal Medicine
Pulmonary, Critical Care and
Occupational Medicine Faculty
Medical School:
The University of Iowa
Residency:
The University of Iowa
Fellowship:
University of California,
San Francisco
University of Texas
Michael J. Welsh, M.D.
Professor of Medicine, Molecular Physiology and Biophysics, and Neurosurgery
Roy J. Carver Biomedical Chair in Internal Medicine
Investigator, Howard Hughes Medical Institute
Director, Pappajohn Institute
Director, Cystic Fibrosis Research Center
Co-Director, Medical Scientist Training Program
Dr. Welsh's clinical interests include the diagnosis and therapy of lung disease, especially airway diseases. His research focuses in three main areas. First, his lab is working to understand the biology and pathogenesis of cystic fibrosis and on developing new treatments. Second, he investigates the physiology and cell biology of airway epithelia, including the cilia that cover their surface. Third, he is investigating the biology of acid sensing ion channels in the central and peripheral nervous systems with an emphasis on their role in fear and neurological diseases.
Honors, Awards, and Organizations
- Alpha Omega Alpha
- Cecile Lehman Mayer Research Award, American College of Chest Physicians
- National Pulmonary Faculty Training Award
- Established Investigator Award, American Heart Association
- Doris F. Tulcin Cystic Fibrosis Research Award
- Paul di Sant'Agnese Distinguished Scientific Achievement Award
- J. Burns Amberson Award, American Thoracic Society
- Treasurer, Association of American Physicians
- Merit Award from NHLBI
- President, American Society for Clinical Investigation
- Institute of Medicine
- American Academy of Arts and Sciences
- American Society for Clinical Investigation Award, Finalist Prize
- Regents Award for Faculty Excellence
- Fellow, American Association for the Advancement of Science
- Roy J. Carver Biomedical Research Chair in Internal Medicine and Molecular Physiology and Biophysics
- National Academy of Sciences
- Vice-President, Association of American Physicians
- President, Association of American Physicians
- Francis Blake Award of the Association of American Physicians
- Second Annual Distinguished Mentoring Award, Roy J and Lucille A Carver College of Medicine
Recent Selected Publications
- Liu, L, Li, Y, Wang, R, Yin, C, Dong, Q, Hing H, Kim C, and Welsh MJ. Drosophila Hygrosensation Requires the TRP Channels Water Witch, Nanchung, and Inactive. Nature, 450:294-298, 2007.
- Ziemann AE, Schnizler MK, Albert GW, Severson MA, Howard MA III, Welsh MJ, and Wemmie JA. Seizure Termination by Acidosis Depends on ASIC1a. Nat. Neurosci., 11:816-822, 2008.
- Rogers CS, StoltZ DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray, Jr. PB, Zabner J, Prather RS and Welsh MJ. Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs. Science. 321:1837-1841, 2008.
- Flynn AN, Itani OA, Moninger TO, and Welsh MJ. Acute Regulation of Tight Junction Ion Selectivity in Human Airway Epithelia. Proc. Natl. Acad. Sci. USA, 106:3591-3596, 2009.
- Sun Y, Liu L, Ben-Shahar Y, Jacobs J, Eberl D, and Welsh MJ. TRPA Channels Distinguish Gravity Sensing from Hearing in Johnston's Organ. Proc. Natl. Acad. Sci. USA, 106:1306-1311, 2009.
- Shah AS, Ben-Shahar Y, Moninger TO, Kline JN, and Welsh MJ. Motile Cilia of Human Airway Epithelia are Chemosensory. Science, 325:1131-1134, 2209.
- Zha X-M, Costa V, Harding AMS, Reznikov L, Benson CJ, and Welsh MJ. ASIC2 subunits Target Acid-Sensing Ion Channels to the Synapse via an Association with PSD-95. J. Neurosci. 29:8438-8446, 2009.
- Ziemann AE, Allen JE, Dahdaleh NS, Drebot II, Coryell M, Wunsch AM, Lynch CM, Faraci FM, Howard MA, Welsh MJ, and Wemmie JA. The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior. Cell 139:1012-1021, 2009.
Links of Interest