Department of Internal Medicine
Pulmonary, Critical Care and
Occupational Medicine Faculty
Education:
The University of Iowa
University of Iceland, Reykjavik
Martha Monick, Ph.D.
Research Professor
Dr. Monick's research interests center on the role of signaling pathways in pulmonary host defenses. Her work examines pathogenesis and treatment options for a number of pulmonary diseases. These include COPD/emphysema, asthma and viral lung diseases. The projects utilize primary human lung macrophages and airway epithelial cells as laboratory models. Her current projects include the role of autophagy in anti-viral immunity, the effect of sumoylation on respiratory syncytial virus replication, the effect of cigarette smoke on autophagy, ER stress and mitochondrial function in alveolar macrophages and the effects of particulates on macrophage biology.
Honors, Awards, and Organizations
- American Association of Immunologists, Member
- American Thoracic Society, Member
- International Cytokine Society, Member
- Society for Leukocyte Biology, Member
- American Society for Biochemistry and Molecular Biology, Member
- Editorial Boards
- Journal of Immunology
- Journal of Infectious Disease
- Best Abstract Award, ATS, 2004
- Exceptional Performance Award, University of Iowa, 2005 and 2008
Recent Publications
- Groskreutz, D.G., Monick, M.M., Babor, E.C., Nyunoya, T, Varga, S.M, Look, D.C., and Hunninghake, G.W. Cigarette Smoke Alters Respiratory Syncytial Virus-Induced Apoptosis and Replication. Am J Respir Cell Mol Biol. 41(2):189-98. 2009.
- Nyunoya T, Monick MM, Klingelhutz Al, Glaser H, Cagley JR, Brown CO, Matsumoto E, Aykin-Burns N, Spitz DR, Oshima J, Hunninghake GW. Cigarette smoke induces cellular senescence via Werner's syndrome protein. Am J Respir Crit Care Med. 15;179(4):27987. 2009.
- Hansdottir S, Monick MM, Hinde Sl, Lovan N, Look DC, Hunninghake GW. Respiratory epithelial cells convert inactive vitamin 0 to its active form: potential effects on host defense. J Immunol. 181 (10):7090-9. 2008.
- Monick, M.M., Powers, L.S., Barrett, C., Hinde, S., Ashare, A., Groskreutz, D., Nyunoya, T., Coleman, M., Spitz, D.R. and Hunninghake, G.W. ERK MAP kinase activity is required for ATP production and mitochondrial integrity in human alveolar macrophages. J. Immunol. 180(11):7485-96. 2008.
- Monick, M.M., Powers, L.S., Hassan, I., Groskreutz, D., Yarovinsky, T.O., Barrett, C.W., Castilow, E.M., Tifrea, D., Varga, S.M. and Hunninghake, G.W. Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL 17. J Immunol. 179(3):1648-58. 2007.
- Monick, M.M., Powers, L.S., Gross, T., Flaherty, D.S., Hunninghake, G.W. Active ERK Contributes to Protein Translation by Preventing JNK-dependent Inhibition of Protein Phosphatase 1. J Immunol. 177(3):1636-45, 2006.