Department of Internal Medicine
Pulmonary, Critical Care and
Occupational Medicine Faculty
Medical School:
Universidad Central de Venezuela
Residency:
University of Texas Southwestern Medical School
Parkland Memorial Hospital, Dallas, Texas
Fellowship:
The University of Iowa
Joseph Zabner, M.D.
Sterba Professor in Internal Medicine
Director, Division of Pulmonary, Critical Care and Occupational Medicine
Vice Chair for Translational Research
Dr. Zabner's research interests are in gene transfer to human airway epithelia in particular to develop gene therapy for cystic fibrosis. Dr. Zabner also has an interest in the fluid composition of the airway surface liquid, and how it affects innate immunity. His clinical interests are in cystic fibrosis and non-cystic fibrosis bronchiectasis.
Honors, Awards, and Organizations
- American Board of Internal Medicine, Board of Pulmonary Diseases, and Board of Critical Care Medicine
- American College of Chest Physicians
- American Thoracic Society
Recent Publications
- Zabner, J., Seiler, M.P., Launspach, J.L., Karp, P.H., Kearney, W.R., Look, D.C., Smith, J.J., Welsh, M.J.: The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing. Proc Natl Acad Sci 10:11614-9, 2000.
- Walters, R.W., Yi, S.M., Keshavjee, S., Brown, K.E., Welsh, M.J., Chiorini, J.A., Zabner, J.: Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer. J Biol Chem 8:20610-6, 2001.
- Walters, R.W., Pilewski, J.M., Chiorini, J.A., Zabner, J. Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5. J Biol Chem, 28:23709-13, 2002.