Department of Internal Medicine
Pulmonary, Critical Care and
Occupational Medicine Faculty
John F. Engelhardt, Ph.D.
Professor of Medicine and Anatomy and Cell Biology
Roy J. Carver Chair in Molecular Medicine
Director, Gene Therapy Center for Cystic Fibrosis and Other Genetic Diseases and Director, Animal Models Core
Interim Head of Anatomy and Cell Biology
Research in Dr. Engelhardt's laboratory focuses on the development of gene therapies for inherited and environmentally induced diseases. Included in these areas of molecular medicine are four areas of research emphasis: 1) pathogenesis and treatment of cystic fibrosis lung disease, 2) mechanisms of submucosal gland development and the identification of stem cells in the airway, 3) redox-mediated mechanisms of ischemia/reperfusion injury in the liver and heart, and 4) biology of adeno-associated virus (AAV) transduction and development of this virus as a vector for gene therapy.
Honors, Awards, and Organizations
- Cystic Fibrosis Foundation Fellowship, 1991-1992
- Phi Kappa Phi Honor Society, Iowa State University, 1985
- High Scholarship Student Award, top 2% Iowa State University, 1985
- Goodspeed-Hayward Undergraduate Scholarship in Biochemistry, 1983-1985
- Philip C. and Ethel F. Ashby Lecturer, University of Oklahoma, 1999
- Roy J. Carver Chair in Molecular Medicine, 2004
- American Society for the Advancement of Science
- American Thoracic Society
- American Society for Cell Biology
American Society for Gene Therapy
- American Association of Anatomists
- American Society for Microbiology
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Education:
B.S., Biochemistry, Iowa State University, 1985
Ph.D., Human Genetics,
Johns Hopkins University, 1990
Fellowship:
University of Michigan |
Recent Publications
- Driskell, R.R., Liu, X., Luo, M., Filali, M., Zhou, W., Abbott, D., Cheng, N., Moothart, C., Sigmund, C.D., and Engelhardt, J.F. 2004. Wnt-Responsive Element Controls Lef-1 Promoter Expression During Submucosal Gland Morphogenesis. Am J Physiol Lung Cell Mol Physiol . (In Press)
- Liu, X., Yan, Z., Luo, M., Zak, R., Li, Z., Driskell, R.R., Huang, Y., Tran, N., and Engelhardt, J.F. 2004. Targeted correction of single-base-pair mutations with adeno-associated virus vectors under nonselective conditions. J Virol 78:4165-4175.
- Fan, C., Li, Q., Zhang, Y., Liu, X., Luo, M., Abbott, D., Zhou, W., and Engelhardt, J.F. 2004. IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. J Clin Invest 113:746-755.
- Click here for additional publications.
Links of Interest
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