Department of Internal Medicine
Pulmonary, Critical Care and
Occupational Medicine Faculty
Education:
Univeristy of Central Florida
University of Florida
Edgardo Rodriguez, Ph.D.
Assistant Professor
Dr. Rodriguez's research interests include the study of dominant neurodegenerative disorders and the development of gene therapies for the treatment of these diseases. His research has focused on the use and development of RNA interference as a therapeutic approach to neurological disease and as a molecular tool to understand gene function in the context of disease. A new and exciting area of studies involves the use of progenitor cells to model human disease in cell culture.
Honors, Awards, and Organizations
- American Society of Gene and Cell Therapy
- Society for Neuroscience
Recent Publications
- Rodríguez-Lebrón E, Gouvion CM, Moore SA, Davidson BL, Paulson HL. Allele-specific RNAi leads to neuropathological improvements in a transgenic model of Alzheimer’s disease. Molecular Therapy. 2009 Sep; 17(9); 1563–1573. NIHMSID: NIHMS 124126
- Denovan-Wright E, Attis M, Rodriguez-Lebron E, Mandel RJ. Sustained striatal CNTF expression negatively affects behavior and gene expression in normal and R6/1 mice. J of Neurosci Res. 2008 Jun;86(8):1748-57.
- Denovan-Wright E, Rodriguez-Lebron E*, Lewin AS, Mandel RJ. Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo. Neurobiol of Dis 2008 Mar;29(3):446-55. *Co-first author. PMCID: PMC2695881
- Miller VM, Nelson RF, Gouvion CM,…Rodriguez-Lebron E (5/9)…Paulson HL. CHIP suppresses polyglutamine aggregation in vitro and in vivo. J Neurosci 2005 Oct 5;25(40):9152-61.
- Rodriguez-Lebron E, Denovan-Wright EM, Nash K, Lewin AS, Mandel RJ. Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington’s disease transgenic mice. Mol Ther 2005 Oct;12(4); 618-33. PMCID: PMC2656966