Department of Internal Medicine

Pulmonary, Critical Care and
Occupational Medicine Faculty

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David Stoltz, M.D., Ph.D.
Assistant Professor

Dr. Stoltz's clinical interests include general pulmonary diseases and lung infections. His research focuses on the pathogenesis of cystic fibrosis related airway disease with a particular emphasis on studying airway epithelial and smooth muscle cells, the role of paraoxonases (PONs) on Pseudomonas aeruginosa quorum-sensing regulation, mucociliary clearance, and advanced airway imaging modalities and analysis.

Honors, Awards, and Organizations

• American Thoracic Society
• American College of Chest Physicians
• American Physiological Society
• Parker B. Francis Pulmonary Fellowship Award, 2007
• Plenary Speaker, North American Cystic Fibrosis Conference, 2010
• Gilead Research Scholar in Cystic Fibrosis, 2012
• Junior Physician Investigator Award, American Federation for Medical Research (AFMR), 2012
• American Asthma Foundation Early Excellence Award (Sandler), 2012
• NIH Director’s New Innovator Award, 2012

Select Publications

1. Stoltz DA, Ozer EA, Taft PJ, Barry M, Liu L, Kiss PJ, Moninger TO, Parsek MR, Zabner J. Drosophila are Protected from Pseudomonas aeruginosa Lethality by Transgenic Expression of Paraoxonase-1. J Clin Invest 118(9):3123-31, 2008.
2. Rogers CS*, Stoltz DA*, Meyerholz DK*, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray Jr PB, Zabner J, Prather RS, Welsh MJ. Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Piglets. Science 321:1837-41, 2008. *Contributed equally to this work.
3. Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA IV, Chang EH, Taft PJ, Ludwig PS, Estin M, Hornick EE, Launspach JL, Samuel M, Rokhlina T, Karp PH, Ostedgaard LS, Uc A, Starner TD, Horswill AR, Brogden KA, Prather RS, Richter SS, Shilyansky J, McCray PB Jr, Zabner J, Welsh MJ. Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth. Science Transl Med 2:29ra31, 2010.
4. Meyerholz, DK, Stoltz DA, Namati E, Ramachandran S, Pezzulo AA, Smith AR, Rector MV, Suter MJ, Kao S, McLennan G, Tearney GJ, Zabner J, McCray PB, and Welsh MJ. Loss of CFTR Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children.  Am J Respir Crit Care Med 182:1251-61, 2010.
5. Rogan MP, Reznikov LR, Pezzulo AA, Gansemer ND, Samuel M, Prather RS, Zabner J, Fredericks DC, McCray PB, Welsh MJ, Stoltz DA. Pigs and Humans with Cystic Fibrosis have Reduced Insulin-like Growth Factor 1 (IGF1) Levels at Birth.  PNAS 107:20571-75, 2010.
6. Chen JH, Stoltz DA, Karp PH, Ernst SE, Pezzulo AA, Moninger TO, Rector MV, Reznikov LR, Launspach JL, Chaloner K, Zabner J, Welsh MJ. Loss of Anion Transport Without Increased Sodium Absorption Characterizes Newborn Porcine Cystic Fibrosis Airway Epithelia.  Cell 143:911-23, 2010.
7. Ostedgaard LO, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rokhlina T, Ernst SE, Hanfland RA, Reznikov LR, Ludwig PS, Rogan MP, Davis GJ, Dohrn CL, Wohlford-Lenane C, Taft PJ, Rector MV, Hornick E, Nassar BS, Samuel M, Zhang Y, Richter SS, Uc A, Shilyansky J, Prather RS, McCray, Jr. PB, Zabner J, Welsh MJ, Stoltz DA. The DF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs.  Science Transl Med 3(74):74ra24, 2011.
8. Bauer C, Adam R, Stoltz DA, Beichel RR.  Computer-Aided Analysis of Airway Trees in Micro-CTs Scans of Ex Vivo Porcine Lung Tissue.  Comput Med Imaging Graph, 2012, in press.

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