Department of Internal Medicine
Lawrence G. Hunsicker, M.D.
Lawrence Hunsicker, MD is Professor of Medicine in the University of Iowa College of Medicine. He retired in 2007 from his long tenure as the Medical Director of Organ Transplantation at University of Iowa Health Care and is now the Director of Transplant Research in the UIHC Organ Transplant Center.
Dr. Hunsicker has extensive experience in the design, execution, and analysis of clinical trials and national databases. He was the cofounder with Dr. Edmund Lewis of the Collaborative Study Group, an international collaboration of academic and practicing nephrologists and endocrinologists that designed and executed the Captopril Study in Type 1 Diabetic Nephropathy (Lewis et al., 1993), the first study that documented in man the ability of blockade of the renin-angiotensin-aldosterone system (RAAS) to slow the progression of diabetic kidney disease, and indeed, the first study that documented any way to affect the progression of kidney disease in humans. Subsequently this group completed and reported the Irbesartan in Diabetic Nephropathy Trial (IDNT) (Lewis et al., 2001) which showed the effectiveness of the angiotensin receptor blocker irbesartan in slowing the progression of the kidney disease of type 2 diabetes. Drs. Hunsicker and Clarke were PIs of the IDNT Data Center, responsible for quality control in the course of the study, for preparing and reporting to the DSMC, and at the end of the trial for performing the data analyses leading to the study publications. The CSG has subsequently completed a study of the impact of sulodexide on diabetic kidney disease, and, again, Dr. Hunsicker played a key role in the design and analysis of the results of this study (Heerspink, 2008).
Dr. Hunsicker was also one of the original 6 PIs of the MDRD Study (Klahr et al., 1994) and was intimately involved in the statistical analyses and reporting of that study. In the area of transplantation, Dr. Hunsicker has been involved from the beginning in the management of the data system for UNOS and was one of the primary architects of the center specific transplant data reports. His publications from the UNOS database include analyses of the impact of center size on transplant outcomes (Hosenpud et al, 1994 and Edwards et al, 1999), the size of the deceased organ donor pool (Sheehy et al., 2003), the outcomes of the use of heart-stopped organ donors (Doshi et al, 2007), and the effectiveness of liver allocation policy exceptions (Suleiman et al, 2008). He is on the Executive Committee of the FAVORIT study of the impact on CV outcomes of reduction of plasma homocysteine levels in stable recipients of kidney transplants and is a coauthor of the papers reporting the baseline characteristics of the patients in this study (Bostom et al, 2009) and of the major outcome paper (Bostom et al, 2011).
He was PI of the USRDS Economic Special Study Center and has published several studies using instrumental variable analysis to study the impact of variables not amenable to testing in controlled trials (Brooks et al, 2006; Zhao et al, 2008). He has served as a consultant to the Data Center for the Frequent Hemodialysis Studies responsible for development of the cost and cost effectiveness analysis. Finally, Dr. Hunsicker is the senior clinician in the Data Center for the Clinical Islet Transplantation (CIT) Consortium, working closely with Dr. Clarke and Ms. Ecklund. In this role he has been an active contributor to the design, execution, oversight, and reporting of these trials. He is the senior “external” study monitor, overseeing the review and coding of adverse events within the CIT studies.
Dr. Hunsicker has been a member of innumerable NIH Study Sections and national advisory committees. Thus, Dr. Hunsicker combines experience with clinical trial design, execution, and analysis, data management and analysis of large data sets, monitoring of study adverse events, clinical transplantation including renal and pancreas transplantation, and economic analysis.
Honors, Awards, and Organizations
- Alpha Omega Alpha
- American Association of Immunologists
- Diplomate, American Board of Internal Medicine and Board of Nephrology
- American College of Physicians, Fellow
- American Council of Transplantation, President, 1987-88
- American Rheumatism Association
- American Society of Nephrology
- The Transplantation Society
- American Society of Transplant Physicians, President, 1987-88
- Central Society for Clinical Research
- International Society of Nephrology
- National Kidney Foundation, Region III, President, 1981-89
- United States Renal Data System, Member, Scientific Advisory Committee, 1988- 1991
- Medical Director, Association of Organ Procurement Organizations, 1995 - 1998
- United Network for Organ Sharing
- Member, Scientific Advisory Committee, 1986 - 1996
- Vice Chairman, 1989-91
- Chair, 1991- 1993
- Chair, Membership and Professional Standards Committee, 1996 - 1997
- President, 1997 - 1998
- Chair, Data Working Group, 2001-06
- Member, FDA Advisory Committee on Antivirals (Immunosuppressives) 1993 –
- Member, HHS Secretary’s Advisory Council on Transplantation, 2001 - 2004
- American Society of Transplantation Roche Lifetime Achievement Award, 2000
- Regents Award for Faculty Excellence, 2003
- National Kidney Foundation David Hume Memorial Award, 2008
- Cleveland Clinic Kasperzak Award, 2010