Department of Internal Medicine
Nephrology Faculty
Medical School:
University of Illinois
Residency:
The University of Iowa
Chief Residency:
The University of Iowa, 2001-02
Kevin Glenn, M.D.
Assistant Professor
Dr. Glenn's research interests include the molecular biology of aging, specifically studying the accumulation of misfolded proteins in normal aging and determining whether this is a marker or a cause of aging. His clinical interest lies in the area of hospitalist medicine.
Recent Grants:
- Ellison Medical Foundation New Scholars in Aging Grant “ Do Misfolded Proteins Accumulate with Age or Senescence?”
- Carver Collaborative Pilot Grant “Protein Quality Control in DYT1 Dystonia” with Dr. Pedro Gonzalez
- VA –Research Career Development Award, “Novel Ubiquitin Ligases in Liver Protein Quality Control.”
Recent Publications
- Mallinger, A.J., Wen, H.M., and Glenn, K.A.: Using a ubiquitin ligase as an unfolded protein sensor. 2009 Submitted.
- Glenn, K.A., Nelson, R.F., Wen, H.M., Mallinger, A.J., Paulson, H.L.: Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. The J. of Biol. Chem. 283: 12717-12729, 2008.
- Nelson, R.F., Glenn, K.A., Zhang, Y., Wen, H., Knutson, T., Gouvion, C., Robinson, B., Zhou, Z., Yang, B., Smith, R.J.H., Paulson, H.: Selective Cochlear Degeneration in Mice Lacking the F-box Protein, Fbx2, a Glycoprotein-Specific Ubiquitin Ligase Subunit. J. Neuroscience 27: 5163-71, 2007.
- Nelson, R. F., Glenn, K. A., Miller, V. M., Wen, H., and Paulson, H.L. A Novel Route for F-box Protein-mediated Ubiquitination Links CHIP to Glycoprotein Quality Control. J. Biol. Chem. 281, 20242-20251, 2006.
- Zhang, C.C., Glenn, K.A., Kuntz, M.A., and Shapiro, D.J. High level expression of full-length estrogen receptor in Escherichia coli is facilitated by the uncoupler of oxidative phosphorylation, CCCP. The Journal of Steroid Biochemistry and Molecular Biology 74, 169-178, 2000.
- Chusacultanachai, S., Glenn, K. A., Rodriguez, A. O., Read, E. K., Gardner, J. F., Katzenellenbogen, B. S., and Shapiro, D. J. Analysis of Estrogen Response Element Binding by Genetically Selected Steroid Receptor DNA Binding Domain Mutants Exhibiting Altered Specificity and Enhanced Affinity. J. Biol. Chem. 274, 23591-23598, 1999.
- Mattick, S., Glenn, K., de Haan, G., and Shapiro, D.: Analysis of Ligand Dependence and Hormone Response Element Synergy in Transcription by Estrogen Receptor. J Steroid Biochem Molec Biol, 60 (5-6):285-294, 1997.
- Lee, Y.P., Adimoolam, S., Liu, M., Subbaiah, P.V., Glenn, K., and Jonas, A.: Analysis of Human Lecithin-Cholesterol Acetyl Transferase Activity by Carboxyl-Terminal Truncation. Biochem Biophys Acta 1344 (3):250-261, 1997.