Department of Internal Medicine
Infectious Diseases Faculty
Mary E. Wilson, M.D.
Kate Daum Professor of Internal Medicine and Microbiology
Dr. Wilson's research interests focus on visceral leishmaniasis, a disease prevalent in many underdeveloped nations. Her studies address several aspects of the pathogenesis of this disease: first, the molecular determinants governing the expression of gp63, a surface protease important for parasite virulence; second, virulence characteristics of Leishmania including their utilization of iron and their resistance to toxic oxidants; third, the cell-mediated immune response to Leishmania and recombinant antigens responsible for eliciting these responses. The latter project is being extended to studies of immunogenetics and immunology in patients with visceral leishmaniasis in a collaborative project with an investigator in Brazil.
Honors, Awards, and Organizations
- American Association of Immunologists
- Diplomate, American Board of Internal Medicine and Board of Infectious Diseases
- American Society for Microbiology
- American Society of Cell Biology
- American Society for Tropical Medicine and Hygiene
- Infectious Diseases Society of America
- NIH Physician Scientist Award
- NIH FIRST Award
- Phi Beta Kappa
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Medical School:
University of Rochester
Residency:
University of Michigan
Fellowship:
University of Virginia |
Recent Publications
- Gomes, N.A., Gattass, C.R., Barreto-de-Souza, V., Wilson, M.E., and DosReis, G.A.: Transforming growth factor beta regulates CTLA-4 suppression of cellular immunity in murine kala-azar. J. Immunol. 164:2001-8,2000.
- Streit, J.A., Recker, T.J., Donelson, J.E. and Wilson, M.E.: BCG expressing Lcr1 of Leishmania chagasi induces protective immunity in susceptible mice. Exp.Parasitol. 94: 33-41, 2000.
- Miller, M.A., McGowan, S.E., Gantt, K.R., Champion, M., Novick, S., Andersen, K.A., Bacchi, C., Yarlett, N., Britigan, B.E., and Wilson, M.E.: Inducible resistance to oxidant stress in the protozoan Leishmania chagasi. J. Biol. Chem. 275:33883-33889, 2000.
- Brittingham, A., Miller, M.A., Donelson, J.E., and Wilson, M.E.: Regulation of GP63 mRNA stability in promastigotes of virulent and attenuated Leishmania chagasi. Mol. Biochem. Parasitol. 112:51-59, 2001.
Links of Interest
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