Department of Internal Medicine

Infectious Diseases Faculty

Jack T. Stapleton, M.D.
Professor and Division Director
Director, University of Iowa HIV Program
Director, Helen C. Levitt Center for Viral Pathogenesis and Disease

As Director of the University of Iowa HIV clinic, Dr. Stapleton is dedicated to overseeing and providing excellent medical care for people infected with the human immunodeficiency virus (HIV) and/or hepatitis C virus (HCV). His laboratory research focuses on the interactions between flaviviruses and HIV in vitro and in vivo. This work originated as epidemiologic and laboratory studies of the effects of co-infection of GB virus type C (GBV-C, a human flavivirus) and HIV, and has expanded to include studies of several other flaviviruses including HCV, Dengue virus and Yellow Fever virus. In addition, Dr. Stapleton has several clinical studies under way related vaccines (HPV, HSV, smallpox) and to the natural history, management and therapy of HIV, hepatitis C virus, and GBV-C.

Honors, Awards, and Organizations

Alpha Omega Alpha
Diplomate, American Board of Internal Medicine and Board of Infectious Diseases
Fellow, American College of Physicians
American Society for Microbiology
American Society for the Study of Liver Disease
Fellow, Infectious Diseases Society of America
Member, HIV Medicine Association
Member, American Association of HIV Medicine
Participation in VA and NIH study sections
Member, Hepatitis Working Group, Multicenter AIDS Cohort Study
Association of American Physicians
FDA Vaccines and Related Biological Products Advisory Committee (VRBPAC)
Editorial Advisory Board, Journal of Infectious Diseases

Jack Stapleton photo

Medical School:
University of Kansas

Residency:
University of North Carolina

Fellowship:
University of North Carolina

Recent Publications

Williams, C.F., Klinzman, D., Yamashita, T., Xiang, J., Polgreen, P.M., Rinaldo, C., Liu, C., Phair, J., Margolick, J.B., Zdunek, D., Hess, G., Stapleton, J.T. Persistent GB virus C infection and survival in HIV-infected men. N. Engl. J. Med. 350:981-990, 2004.
Xiang, J., George, S.L., Wünschmann, S., Chang, Q., Klinzman, D., Stapleton, J.T. GB virus C infection inhibits HIV-1 replication by increasing RANTES, MIP-1a, MIP-1b, and SDF-1. Lancet, 363:2040-2046, 2004.
Xiang J, Martinez-Smith C, Gale Jr. M, Chang Q, LaBrecque DR, Schmidt WN, Stapleton JT. GB Virus type C NS5A sequence polymorphisms: Association with interferon susceptibility and inhibition of PKR-mediated eIF-2a phosphorylation. J Interferon Cytokine Res, 25:261-270, 2005.
Xiang, J., McLinden, J.H., Chang, Q., Kaufman, T.M., Stapleton, J.T. An 85 amino acid segment of the GB Virus type C NS5A phosphoprotein inhibits HIV-1 replication in CD4+ Jurkat T-cells. Proc Natl. Acad. Sci. USA, 103:15570-15575, 2006.
Wünschmann, S., Müller, H.M., Stipp, C.S., Hemler, M.E., Stapleton, J.T. In Vitro interaction between hepatitis C virus (HCV) envelope glycoprotein E2 and serum lipoproteins (LPs) results in enhanced cellular binding of both HCV E2 and LPs. J. Infect. Dis, 194:1058-1067, 2006.
McLinden, J.H., Kaufman, T.M., Xiang, J., Chang, Q., Klinzman, D., Engel, A.M., Hess, G., Schmidt, U., Houghton, M., Stapleton, J.T. Characterization of an immunodominant antigenic site on GB virus C glycoprotein E2 that is involved in cell binding. J. Virol., 80:12131-12140. 2006.
Kaufman TM, McLinden JH, Xiang J, Engel AM, Stapleton JT. The GBV-C envelope glycoprotein E2 does not interact specifically with CD81. AIDS 21:10451048, 2007.
Chamie G, Bonacini M, Bangsberg DR, Stapleton JT, Hall C, Overton ET, Scherzer R, Tien PC. Factors associated with seronegative chronic hepatitis C virus infection in HIV-infection. Clin Infect Dis 44:577-583, 2007.
Handelsman E, Cheng I, Thompson B, Hershow R, Mofenson LM, Hollinger FB, Chen KT, Burchett SK, Klinzman D, Stapleton JT and the Women and Infants Transmission Study Group (WITS). Impact of GB Virus type C Infection on Mother-to-Child HIV Transmission in the Women and Infants Transmission Study Cohort. HIV Medicine, 8:561- 567. 2007.
Stapleton JT. A new variable influencing HCV-related liver disease in HIV-HCV co-infected individuals? Gastroenterology, 133:2042-2045, 2007.
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Links of Interest

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