Department of Internal Medicine
Hematology, Oncology and Blood &
Marrow Transplantation Faculty
Steven R. Lentz, M.D., Ph.D.
Professor and Division Director
Sebelin Funded Hamilton Hematology Chair
In the clinic, Dr. Lentz cares for patients with hemostatic and hematological disorders.
The major focus of research in Dr. Lentz's laboratory is endothelial function in vascular diseases and tissue injury, with particular emphasis on structure, function, and regulation of hemostatic proteins. Current areas of investigation include the following:
Antithrombotic function in hyperhomocysteinemia. This project originated from studies in this laboratory on prothrombotic effects of elevated levels of homocysteine, an amino acid that is associated with venous thrombosis, stroke, myocardial infarction, and peripheral vascular disease. We were among the first to demonstrate impaired vascular function in moderate hyperhomocysteinemia. In collaboration with investigators at McMaster University, we recently demonstrated that hyperhomocysteinemia alters lipid biosynthesis via the ER stress/SREBP pathway, which may represent a novel mechanism for the development of hepatic steatosis and vascular disease in hyperhomocysteinemia. Current studies are directed toward investigating the mechanisms of vascular dysfunction in hyperhomocysteinemia using molecular genetic approaches. |
Medical School:
Washington University
Graduate School:
Molecular Biology,
Washington University
Residency:
Barnes Hospital
Fellowship:
Washington University |
Structure and function of keratinocyte thrombomodulin. This project originated from our discovery that the anticoagulant protein thrombomodulin is expressed in a highly regulated fashion by keratinocytes in squamous epithelium. Our recent studies in genetically-altered mice suggest that thrombomodulin regulates tissue repair during cutaneous wound healing.
Signal transduction by thrombin and collagen. Thrombin is a multifunctional serine protease that acts as a pivotal enzyme in blood coagulation. We have characterized thrombin receptor signal transduction in platelets and T cell lines, and demonstrated functional crosstalk between thrombin receptors and the T cell antigen receptor. In collaborative studies, we have demonstrated that the adapter protein SLP-76 is essential for platelet signal transduction in response to collagen, but not thrombin. Currently, we are using genetic approaches in mice to define the hemostatic consequences of impaired collagen signal transduction.
Honors, Awards, and Organizations
- Alpha Omega Alpha
- American Association for the Advancement of Science
- Associate Editor, Arteriosclerosis, Thrombosis, and Vascular Biology
- Diplomate, American Board of Internal Medicine and Board of Hematology
- American College of Physicians
- American Federation for Medical Research
- Fellow, American Heart Association Council on Arteriosclerosis, Thrombosis, and Vascular Biology
- American Society for Biochemistry and Molecular Biology
- American Society for Clinical Investigation
- American Society of Hematology
- Central Society for Clinical Research
- Department of Veterans Affairs, Career Development Award
- International Society on Thrombosis and Haemostasis
- Investigator, Cancer and Leukemia Group B
- Phi Beta Kappa
Recent Publications
- Dayal, S., Arning, E., Bottiglieri, T., Böger, R.H., Sigmund, C.D., Faraci, F.M., and Lentz, S.R. Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke (2004) 35:1957-1962.
- Devlin, A.M., Bottiglieri, T., Domann, F.E., and Lentz, S.R. Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. J. Biol. Chem. (2005) 280:25506-25511.
- Dayal, S., Devlin, A.M., McCaw, R.B., Liu, M.L., Arning, E., Bottiglieri, T., Shane, B., Faraci, F.M., and Lentz, S.R. Cerebral vascular dysfunction in methionine synthase-deficient mice. Circulation (2005) 112:737-744
- Jobe, S.M., Leo, L., Eastvold, J., Dickneite, G., Ratliff, T.L., Lentz, S.R., and Di Paola, J. Role of FcRγ and factor XIIIA in coated platelet formation. Blood (in press).
- Click here for additional publications.
Links of Interest
Back to Hematology-Oncology Faculty List
|
