Department of Internal Medicine
Hematology, Oncology and Blood & Marrow Transplantation Faculty
Medical School:
Rush Medical College
Residency:
University of Chicago
Fellowship:
University of Chicago
Special Training:
Rush University, Pharmacology
Raymond J. Hohl, M.D., Ph.D.
Holden Family Chair
Professor of Medicine and Pharmacology
Associate Chair, Department of Internal Medicine
Associate Director for Translational Research, Holden Comprehensive Cancer Center
Dr. Hohl's research interests focus on understanding the interactions between mevalonic acid and cholesterol biosynthesis and the proliferation of acute myeloid leukemia cells. These studies investigate the relative affinities of various growth regulating proteins, such as RAS and KREV1, for the isoprene intermediates of the mevalonic acid to cholesterol biosynthetic pathway. His clinical interests involve evaluation of the potential role for pharmacologic inhibitors of this biosynthetic pathway in the treatment of various hematologic malignancies and solid tumors. Additionally, he has continued interest in studying how various erythrocyte enzymothathies predispose the human red blood cell to drug-induced oxidative damage.
Honors, Awards, and Organizations
- Alpha Omega Alpha
- American Association for Cancer Research
- Diplomate, American Board of Internal Medicine, Board of Medical Oncology, and Hematology
- American College of Physicians, Fellow
- Carver Clinician Scientist Award, 1991
- American Society of Clinical Oncology, Young Investigator Award, 1992
- American Society of Hematology
- Paul E. Carson Pharmacology Award, 1988
- PMA Faculty Development Award in Clinical Pharmacology, 1992-95
- Outstanding Research Award-General Clinical Research Centers Program Directors' Association, 1996
- Laureate Award, Iowa Chapter of the American College of Physicians, 2001
Recent Publications
- Hamadmad, S., Henry, M., Hohl, R.J.: Erythropoietin Receptor Signal Transduction Requires Protein Geranylgeranylation, Journal of Pharmacology and Experimental Therapeutics, 316(1): 403-409, 2006.
- Holstein, S.A., Knapp, H.R., Clamon, G.H., Murry, D.J., Hohl, R.J.: Pharmacodynamic Effects of High Dose Lovastatin in Subjects with Advanced Malignancies, Cancer Chemotherapy and Pharmacology, 57(2): 155-164, 2006.
- Murthy, S., Tong, H., Hohl, R.J.: Regulation of Fatty Acid Synthesis by Farnesyl Pyrophosphate, Journal of Biological Chemistry, 280 (51): 41793-41804, 2005.
- Lewis, K., Holstein, S.A., Hohl, R.J.: Lovastatin Alters the Isoprenoid Biosynthetic Pathway in Acute Myelogenous Leukemia Cells In Vivo, Leukemia Research, 29: 527-533, 2005.
- Tong, H., Holstein, S.A., Hohl, R.J.: Simultaneous Determination of Farnesyl an Geranylgeranyl Pyrophosphate Levels in Cultured Cells, Analytical Biochemistry, 336: 51-59, 2005.
- Kim, M., Kleckley, T., Wiemer, A.J., Holstein, S.A., Hohl, R.J., Wiemer, D.F.: "Synthesis and Activity of Fluorescent Isoprenoid Pyrophosphate Analogues", Journal of Organic Chemistry, 69: 8186-8193, 2004.
- Holstein, S.A., Hohl, R.J.: Omnipresent Isoprenoids: Remarkable Diversity of Form and Function, Lipids, 39 (4): 293-309, 2004.
- Ownby, S.E., Hohl, R. J.: Isoprenoid Alcohols Restore Protein Isoprenylation in Time-Dependent Manner Independent of Protein Synthesis, Lipids, 38, 687-804, 2003.
- Holstein, S.A., Hohl, R.J.: Monoterpene Regulation of Ras-Related Protein Expression. Journal of Lipid Research, 44: 1209-1215, 2003.
- Holstein, S.A., Wohlford-Lenane, C.L., Wiemer, D.F., Hohl, R.J.: Isoprenoid Pyrophosphate Analogues Regulate Expression of Ras-Related Proteins. Biochemistry, 42: 4384-4391, 2003.
- Chen, X., Wiemer, A.J., Hohl, R.J., Wiemer, D.F.: Stereoselective Synthesis and Bioactivity of the 5'-Hydroxy-5'-Phosponate Derivatives of Cytidine and Cytosine Arabinoside. The Journal of Organic Chemistry, 67: 9331-9339, 2002.
- Chen, X., Wiemer, A.J., Hohl, R.J., Wiemer, D.F.: Stereoselective Synthesis and Bioactivity of the 5'-Hydroxy-5'- Phosponate Derivatives of Cytidine and Cytosine Arabinoside. The Journal of Organic Chemistry, 67: 9331-9339, 2002.
Links of Interest