Department of Internal Medicine
Hematology, Oncology and Blood & Marrow Transplantation Faculty
Medical School:
Rush Medical College
Residency:
University of Chicago
Fellowship:
University of Chicago
Special Training:
Rush University, Pharmacology
Raymond J. Hohl, M.D., Ph.D.
Holden Family Chair
Professor of Medicine and Pharmacology
Associate Chair of Technology Transfer
Associate Director, Clinical and Translational Research, Holden Comprehensive Cancer Center
Dr. Hohl's research interests focus on understanding the interactions between mevalonic acid and cholesterol biosynthesis and the proliferation of acute myeloid leukemia cells. These studies investigate the relative affinities of various growth regulating proteins, such as RAS and KREV1, for the isoprene intermediates of the mevalonic acid to cholesterol biosynthetic pathway. His clinical interests involve evaluation of the potential role for pharmacologic inhibitors of this biosynthetic pathway in the treatment of various hematologic malignancies and solid tumors. Additionally, he has continued interest in studying how various erythrocyte enzymothathies predispose the human red blood cell to drug-induced oxidative damage.
Honors, Awards, and Organizations
- Alpha Omega Alpha
- American Association for Cancer Research
- Diplomate, American Board of Internal Medicine, Board of Medical Oncology, and Hematology
- American College of Physicians, Fellow
- Carver Clinician Scientist Award, 1991
- American Society of Clinical Oncology, Young Investigator Award, 1992
- American Society of Hematology
- Paul E. Carson Pharmacology Award, 1988
- PMA Faculty Development Award in Clinical Pharmacology, 1992-95
- Outstanding Research Award-General Clinical Research Centers Program Directors' Association, 1996
- Laureate Award, Iowa Chapter of the American College of Physicians, 2001
Recent Publications [view PubMed listing]
- Wiemer, A.J., Yu, J.S., Shull, L.W., Barney, R.J., Wasko, B.M., Lamb, K.M., Hohl, R. J., Wiemer, D.F.: Pivaloyloxymethyl-modified Isoprenoid Bisphosphonates display enhance Inhibition of Cellular Geranylgeranyl, Bioorganic & Medicinal Chemistry, 16 (7), 3652-3660, 2008
- Tong, H., Wiemer, A.J., Neighbors, J., Hohl, R.J.: Quantitative Determination of Farnesyl and Geranylgeranyl Diphosphate Levels in Mammalian Tissue, Analytical Biochemistry, 378, 138-143, 2008
- Holstein, S.A., Stokes, J.B., Hohl, R.J.: Renal Failure and Recovery Associated with Second-Generation Bcr-Abl Kinase Inhibitors in Imatinib- Resistant Chronic Myelogenous Leukemia, Leukemia Research, 33(2), 344-347, 2009
- Kuder, C.H., Neighbors, J.D., Hohl, R.J., Wiemer, D.F.: Synthesis and Biological Activity of a Fluorescent Schweinfurthin Analogue, Bioorganic Medicinal Chemistry, 17, 4718-4723, 2009
- Wiemer, A.J. Hohl, R.J., Wiemer, D.F.: The Intermediate Enzymes of Isoprenoid Metabolism as Anticancer Agents, Anticancer Agents Med Chem, 9 (5), 526-542, 2009
- Holstein, S.A., Tong, H., Hohl, R.J: Differential Activities of Thalidomide and Isoprenoid Biosynthetic Pathway Inhibitors in Multiple Myeloma Cells, Leukemia Research, 34 (3), 344-351, 2009
- Holstein, S.A., Tong, H., Hohl, R.J.: Quantitative Determination of Geranyl Diphosphate Levels in Cultured Human Cells, Lipids, 44 (11), 1055-1062, 2009
- Ulrich, N. C., Kodet, J. G., Mente, N. R., Kuder, C. H., Beutler, J. A., Hohl, R. J., Wiemer, D. F.: Structural Analogues of Schweinfruthin F: Probing the Steric, Electronic and Hydrophobic Properties of the D-Ring Substructure, Biorg. Med. Chem, 18 (4), 1676-1683, 2010.
Links of Interest