Dr. Macfarlane is the co-director of the Great Plains Regional Hemophilia Center, and the director of the adult hemophilia service at the University of Iowa. His research interests are in the biomedical mechanisms (particularly protein phosphorylation and methylation) by which blood platelets and other blood cells respond to pharmacological agonists or hormones. He has developed a cationic detergent gel system that is capable of resolving the nuclear phosphoproteins extracted from intact cells, which increase their phosphorylation when the cells are exposed to differentiating agents. This system is being used to purify these proteins from leukemia cells and the analogous proteins from blood platelets to study their function.

Honors, Awards, and Organizations

• American Heart Association
• British Microcirculation Society
• Central Society for Clinical Research
• Editor, Thrombosis Research
• International Society of Hemostasis and Thrombosis
• New York Academy of Sciences
• Royal College of Physicians of England, Licentiate
• Royal College of Surgeons of England, Member

Medical School:
London University

Graduate School:
Experimental Pathology,
University of London

Residency:
St. Bartholomew's Hospital, London, England

Fellowship:
Royal College of Surgeons, England 
The University of Iowa