Department of Internal Medicine

Hematology, Oncology and Blood &  Marrow Transplantation Faculty

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Anil Chauhan, M.Tech., Ph.D.
Assistant Professor

The major focus of research in Dr. Chauhan laboratory is on the role of adhesion molecules in thrombosis and inflammation. Dr. Chauhan laboratory uses intra vital microscopy to study interaction of platelet and leukocyte with endothelium followed by stimulation/ injury. Most of work involves genetically modified mice combined with disease models such as atherosclerosis and ischemic stroke.

Honors, Awards, and Organizations

• Young Investigator Award, The International Society on Thrombosis and Haemostasis, 2005
• Mary Rhodes Gibson Memorial Award in Hemostasis & Thrombosis, The American Society of Hematology, 2007
• ASH Scholar award, American Society of Hematology, 2009

Links of Interest

Video: Spontaneous thrombi in microvenule

Video: Recombinant ADAMTS13 inhibits thrombus growth in FeCl3-injured arterioles

Video: ADAMTS13 deficiency in mice results in increased leukocyte adhesion in inflamed venules

Recent Publications

1. Kisucka J, Chauhan AK, Zhao BQ, Patten IS, Yesilaltay A, Krieger, M ,Wagner DD. Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis. Blood 2009, Dec 24 [Epub ahead of print].
2. Banno F, Chauhan AK, Kokame K, Yang J, Miyata S, Wagner DD, Miyata T. The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation. Blood 2008, Dec 24, [Epub ahead of print].
3. Lu, F, Chauhan, AK, Fernandes, SM, Walsh, MT, Wagner, DD, Davis III, AE. The effect of C1 inhibitor on intestinal ischemia and reperfusion injury. Am J of Physiol Gastrointest Liver Physiol, 295 (5), G1042-9, 2008.
4. Kisucka, J*, Chauhan AK*, Patten IS, Yesilaltay, A, Neumann C, Van Etten, RA, Krieger M, Wagner DD. Peroxiredoxin1 plays an important role in preventing endothelial activation and early atherosclerosis. Circ Res, 103 (6), 598-605, 2008.* Both authors contributed equal to the work.
5. Bergmeier W, Chauhan AK, Wagner DD. Glycoprotein Ibα and von Willebrand factor in primary platelet adhesion and thrombus formation: lessons from mutant mice. Thromb & Haemost, 99 (2), 264-70, 2008.
6. Chauhan AK, Walsh MT, Zhu G, Ginsburg D, Wagner DD, Motto DG. The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis. Blood, 111 (7), 3452-3457, 2008.
7. Chauhan AK, Kisucka J, Cozzi MR, Walsh MT, Moretti FA, Battiston M, Mazzucato De Marco L, Baralle FE, Wagner DD, Muro AF. Prothrombotic effects of fibronectin isoforms containing the EDA domain. Arterioscler Thromb Vasc Biol, 28 (2), 296-301, 2007.  Comment in Arterioscler Thromb Vasc Biol, 28 (2), 203-204, 2008.
8. Frederix K*, Chauhan AK*, Kisucka J, Zhao BQ, Hoff EI, Sprok HM, Ten Cate H, Wagner DD. Platelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice. Brain Res, 1185, 239-245, 2007. * Both authors contributed equal to the work.
9. Chauhan AK, Kisucka J, Brill A, Walsh MT, Scheiflinger F, Wagner DD. ADAMTS13- a new link between thrombosis and inflammation. J. Exp. Med., 205 (9), 2065-74, 2008.
10. Moretti FA, Chauhan AK, Iaconcig A, Porro F, Baralle FE, Muro AF. A major fraction of fibronectin present in the extracellular matrix of tissues is plasma-derived. J Biol Chem, 282 (38): 28057-62, 2007.
11. Chauhan AK, Goerge T, Schneider SW, Wagner DD. Formation of platelet strings and microthrombi in the presence of ADAMTS13 inhibitor does not require P-selectin or β3 integrin.  J Thromb. Haemost, 5 (3): 583-589, 2007.
12. Chauhan AK, Kisucka J, Lamb CB, Bergmeier W, Wagner DD. von Willebrand Factor and Factor VIII are independently required to form stable occlusive thrombi in injured veins. Blood, 109 (6): 2424-2429, 2007.
13. Kamath A, Chauhan AK, Kisucka J, Loscalzo J, Handy D.E, Wagner D. D. Elevated levels of homocysteine compromise blood brain barrier integrity in mice. Blood, 107 (2), 591-593, 2006.
14. Chauhan AK, Motto DG, Lamb CB, Bergmeier W, Dockal M, Plaimauer B, Scheiflinger F, Ginsburg D, Wagner DD. Systemic anti-thrombotic effect of metalloproteinase ADAMTS13. J. Exp. Med., 203(3), 767-776, 2006.
15. Matuskova J, Chauhan AK, Cambien B, Astrof S, Dole VS, Piffath CL, Hynes RO, Wagner DD. Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Arterioscler Thromb Vasc Biol., 26(6), 1193-1195, 2006.
16. Yang D, Zhang Y, Nguyen, Koupenova M, Chauhan AK, Makitalo M, Jones MR, Seldin D, Toslelli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K. The A2b Adenosine receptor protects against inflammation and excessive vascular adhesion. J. Clin. Invest. 116(7), 1913-1923, 2006.
17. Chauhan AK, Porro F, Baralle FE, Muro AF. Impaired motor coordination in mice lacking the EDA exon of the fibronectin gene. Behav. Brain Res., 161, 31-8, 2005.
18. Motto DG, Chauhan AK, Zhu G, Homeister J, lamb CB, Desch KC, Zhang W, Tsai HM, Wagner DD, Ginsburg D. Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13- deficient mice. J. Clin. Invest. 115(10): 2752-61, 2005.
19. Chauhan AK, Iaconcig A, Baralle FE, Muro AF. Alternative splicing of fibronectin: a mouse model demonstrates the identity of in vitro and in vivo systems and the processing autonomy of regulated exons in the adult mice. Gene, 7, 324, 55-63, 2004.
20. Muro AF*, Chauhan AK *, Gajovic S, Iaconcig A, Porro F, Stanta S, Baralle FE. Regulated splicing of the fibronectin EDA exon (FN) is essential for proper skin wound healing and normal life span. J Cell Biol, Volume 162, Number 1, 149-170, 2003. * Both authors contributed equal to the work. Comment in, J Cell Biol , Volume 162, 2003.

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