Department of Internal Medicine
Gastroenterology-Hepatology Faculty
Medical School:
Wayne State University
Residency:
Johns Hopkins University
Fellowship:
The University of Iowa
Graduate School:
Wayne State University
David Elliott, M.D., Ph.D.
Professor
Dr. Elliott's research interest focuses on the mechanisms that control inflammatory reactions. His studies include the liver granulomas that develop in murine schistosomiasis; the role of the neuropeptide somatostatin in the regulation of the granulomatous response; and soluble mediators released by granuloma cells that affect inflammatory responses. He employs the ELISA assays of lymphokine production, cellular cloning, Northern blot analysis of granuloma mRNA, reverse transcription PCR or granuloma lymphocyte mRNA, RNASE protection assays, and molecular cloning. His key interests are immunology, immunoregulation, granulomatous inflammation, schistosomiasis, and inflammatory bowel diseases, lymphokines, T cell receptor.
Recent Publications
- Elliott, D.E., Blum, A.M., Li, J., Metwali, A., and Weinstock, J.V.: Preprosomatostatin Messenger RNA is Expressed by Inflammatory Cells and Induced by Inflammatory Mediators and Cytokines, J. Immunol. 1998; 160:3997-4003.
- Blum, A.M., Elliott, D.E., Metwali, A., Li, J., Qadir, K., Weinstock, J.V.: Substance P Regulates Somatostatin Expression in Inflammation. J. Immunol. 1998; 161: 6316-22. Developed several assays used in this study .
- Blum, A.M., Metwali, A., Kim-Miller, M., Li, J., Qadir, K., Elliott, D.E., Lu, B., Fabry, Z., Gerard, N., and Weinstock, J.V.: The Substance P Receptor is Necessary for Normal Granulomatous Response in Murine Schistosomiasis mansoni. J. Immunol. 1999; 162: 6080-85. Developed assays and helped design and troubleshoot the experiments.
- Elliott, D.E., Li, J., Blum, A., Metwali, A., Patel, Y.C., Weinstock, J.V.: SSTR2A is the Dominant Receptor Subtype Expressed by Inflammatory Cells, Is Widely Expressed and Directly Regulates T cell IFN g Release. European J. Immunol 1999; 29: 2454-63.
- Elliott, D.E., Urban, J.F., Curtis, A.K., Weinstock, J.V.: Does the failure to acquire Helminthic Parasites Predispose to Crohn's Disease. FASEB Journal 2000; 14: 1848-55.
Links of Interest