Department of Internal Medicine
Cardiovascular Medicine Faculty
Graduate School:
Case Western Reserve University
Postdoctoral Fellowship:
Washington University
Thomas J. Hund, Ph.D.
Associate
Dr. Hund's reseach interests include computer modeling of the cardiac action potential, calcium transient and intracellular signaling pathways, the role of CaMKII in electrical remodeling and arrhythmias post-infarction, and regulation of gap junctions and cell-cell communication during myocardial ischemia.
Honors, Awards, and Organizations
- Ruth L. Kirchstein National Research Service Award, NIH, 2006
Select Publications
- Hund, T.J., Wright, P., Dun, W., Snyder, J.S., Boyden, P.A., and Mohler, P.J. Regulation of ankyrin-B-based targeting pathway following myocardial infarction. Cardiovasc Res. 2009;81:742-9.
- Thiel, W.H., Chen, B., Hund, T.J., Koval, O.M., Purohit, A., Song, L.S., Mohler, P.J., and Anderson, M.E. Proarrhythmic defects in Timothy Syndrome require calmodulin kinase II. Circulation. 2008;118:2225-2234.
- Le Scouarnec, S., Bhasin, N., Vieyres, C., Hund, T.J., Cunha, S.R., Koval, O., Marionneau, C., Chen, B., Wu, Y., Demolombe, S., Song, L.S., Le Marec, H., Probst, V., Schott, J.J., Anderson, M.E., and Mohler, P.J. Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease. Proc Natl Acad Sci.,USA. 2008;105:15617-22.
- Hund, T.J., Decker, K.F., Kanter, E., Mohler, P.J., Boyden, P.A., Schuessler, R.B., Yamada, K.A., Rudy, Y.. Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling. J Mol Cell Cardiol. 2008;45:420-8.
- Lowe, J.S., Palygin, O., Bhasin, N., Hund, T.J., Boyden, P.A., Shibata, E., Anderson, M.E., and Mohler, P.J. Voltage-gated Nav channel targeting in heart requires an ankyrin-G-dependent pathway. J Cell Biol. 2008;180:173-186.
- Hund, T.J., Lerner, D.L., Yamada, K.A., Schuessler, R.B., and Saffitz, J.E. Protein kinase Cε mediates salutary effects on electrical coupling induced by ischemic preconditioning. Heart Rhythm. 2007;4:1183-93
- Hund, T.J. and Rudy, Y. Rate dependence and regulation of the action potential and calcium transient in a canine cardiac ventricular cell model. Circulation. 2004; 110:3168-3174.
- Hund, T.J., Otani, N.F., Kucera, J.P., and Rudy, Y. Ionic charge conservation and long-term steady state in the Luo-Rudy dynamic model of the cardiac cell. Biophys J. 2001; 81:3324-31.