Department of Internal Medicine
Cardiovascular Medicine Faculty
Medical School:
University of North Carolina
Residency:
Duke University Medical Center
The University of Iowa
Fellowship:
The University of Iowa
Robert B. Felder, M.D.
Professor
Dr. Felder's laboratory utilizes electrophysiological, immunohistochemical and molecular techniques to explore the contribution of the brain to the pathophysiology of cardiovascular disease states. The primary focus is upon heart failure in rodent models, with an emphasis on the forebrain influences of pro-inflammatory cytokines and the renin-angiotensin-aldosterone system on volume regulation and sympathetic drive.
Honors, Awards, and Organizations
- Alpha Omega Alpha
- American College of Physicians - Fellow , 1983-2004
- American Heart Association - Fellow, Council on Circulation, 1986-1999
- American Heart Association - Fellow, Council for High Blood Pressure Research, 1988-2004
- American Heart Association - Fellow, Council on Clinical Cardiology, 1979-2004
- Central Society for Clinical Research, 1986-2003
- Society for Neuroscience
- American Physiological Society - Fellow, Cardiovascular Section
- International Society for Autonomic Neuroscience
- Clinician Scientist Award, American Heart Association, 1980-1985
- Established Investigator Award, American Heart Association, 1985-90
- Editorial Board, American Journal of Physiology, Heart and Circulatory Physiology, 1991-98
- Editorial Board, American Journal of Physiology, Regulatory, Integrative and Comparative Physiology, 1994-1998
- Cardiovascular Regulation Study Committee, American Heart Association, 1994-1998
- Hypertension and Microcirculation Study Section, National Institutes of Health, 2012-2018
Selected Recent Publications
- Wei, S.G., Zhang, Z.H., Yu, Y., Weiss, R.M., Felder, R.B.: Central Actions of the Chemokine Stromal Cell-Derived Factor-1 Contribute to Neurohumoral Excitation in Heart Failure Rats. Hypertension, 59:991-998, 2012.
- Zhang, Z.H., Yu, Y., Wei, S.G., Felder, R.B.: Aldosterone-Induced Brain MAPK Signaling and Sympathetic Excitation Are Angiotensin-II Type-1 Receptor Dependent. Am. J. Physiol., 302:H742–H751, 2012.
- Yu, Y., Zhang, Z.H., Wei, S.G., Weiss, R.M., Felder, R.B.: Peroxisome Proliferator-Activated Receptor-γ Regulates Inflammation and Renin-Angiotensin System Activity in Hypothalamic Paraventricular Nucleus and Ameliorates Peripheral Manifestations of Heart Failure. Hypertension, 59:477-484, 2012.
- Yu, Y., Zhang, Z.H., Wei, S.G., Serrats, J., Weiss, R.M., and Felder, R.B.: Brain Perivascular Macrophages and the Sympathetic Response to Inflammation in Rats after Myocardial Infarction (Subject of Editorial Comment). Hypertension, 55:652-659, 2010.
- Wei, S.G., Yu, Y, Zhang, Z.H., and Felder, R.B.: Angiotensin II Upregulates Hypothalamic AT1 Receptor Expression in Rats via the Mitogen-Activated Protein Kinase Pathway. Am. J. Physiol. Heart. Circ. Physiol. 296:H1425-1433, 2009.
- Wei, S.G., Yu,Y., Zhang, Z.H., Weiss, R.M., and Felder R.B.: Mitogen-Activated Protein Kinases Mediate Upregulation of Hypothalamic Angiotensin II Type 1 Receptors in Heart Failure Rats. (Subject of Editorial Comment). Hypertension, 52:679-686, 2008.
- Wei, S.G., Yu, Y., Zhang, Z.H., Weiss, R.M., and Felder, R.B.: Angiotensin II Triggered p44/42 Mitogen-Activated Protein Kinase Mediates Sympathetic Excitation in Heart Failure Rats. Hypertension, 52:342-350, 2008.
- Yu, Y., Wei, S.G, Zhang, Z.H., Gomez-Sanchez, E.P., Weiss, R.M., and Felder, R.B.: Does Aldosterone Upregulate the Brain Renin-Angiotensin System in Rats with Heart Failure? (Subject of Editorial Comment). Hypertension, 51:727-733, 2008.
- Kang, Y.M., Zhang, Z.H., Xue, B., Weiss, R.M., and Felder, R.B: Inhibition of Brain Pro-inflammatory Cytokine Synthesis Reduces Hypothalamic Excitation in Rats with Ischemia-Induced Heart Failure. Am. J. Physiol., 295:H227-H236, 2008
- Zhang, Z.H., Yu, Y., Kang, Y.M., Wei, S.G., and Felder, R.B: Aldosterone Acts Centrally to Increase Brain Renin-Angiotensin System Activity and Oxidative Stress in Normal Rats. Am. J. Physiol., 294: H1067-H1074, 2008.
- Yu, Y., Zhang, Z.H., Wei, S.G., Chu, Y., Weiss, R.M., Heistad, D.D., and Felder, R.B: Central Gene Transfer of Interleukin-10 Reduces Hypothalamic Inflammation and Evidence of Heart Failure in Rats after Myocardial Infarction. (Subject of Editorial Comment). Circ. Res., 101:304-312, 2007.