Department of Internal Medicine
Cardiovascular Medicine Faculty
Medical School:
The University of Iowa
Residency:
University of Texas,
Southwestern
Fellowship:
The University of Iowa
Peter Snyder, M.D.
Professor of Medicine and Molecular Physiology and Biophysics
Vice Chair for Faculty Advancement
Director of Cardiovascular Research Programs
Dr. Snyder's clinical interest is general cardiology. His research interest is understanding function and regulation of the DEG/ENaC family of ion channels. Defects in those channels cause hypertension and contribute to the pathogenesis of cystic fibrosis.
Honors, Awards, and Organizations
- Alpha Omega Alpha
- Astra-Merck Young Investigator Award, 1998
- American Heart Association Katz Basic Science Research Prize for Young Investigators, 1998
- American Society for Clinical Investigation, 2002
- Gill Heart Institute Young Physician Scientist Award, 2002
- American Society of Hypertension Young Scholar Award, 2003
- Association of University Cardiologists, 2003
- Association of American Physicians, 2009
Recent Publications
- Collier, D.M., Snyder, P.M.: Identification of Epithelial Na+ Channel (ENaC) Intersubunit Cl- Inhibitory Residues Suggests a Trimeric Alpha Gamma Beta Channel Architecture. J. Biol. Chem., 286(8):6027-32, 2011. Epub 2010 Dec 13
- Zhou, R., Kabra, R., Olson, D.R., Piper, R.C., Snyder, P.M.: Hrs Controls Sorting of the Epithelial Na+ Channel Between Endosomal Degradation and Recycling Pathways. J. Biol. Chem., 285(40):30523-30, 2010. Epub 2010 Jul 30
- Ben-Shahar, Y., Lu, B., Collier, D.M., Snyder, P.M., Schnizler, M., Welsh, M.J.: The Dosophila Gene CheB42a is a Novel Modifier of Deg/ENaC Channel Function. PLoS One, 5(2):e9395, 2010.
- Yang, T., Gurrola II, J.G., Wu, H., Chiu, S.M., Wangemann, P., Snyder, P.M., and Smith, R.J.H.: Mutations of KCNJ10 Together with Mutations of SLC26A4 Cause Digenic Nonsyndromic Hearing Loss Associated with Enlarged Vestibular Aqueduct Syndrome. Am. J. Hum. Genet., 84:1-7, 2009.
- Zha, X.M., Wang, R., Collier, D.M., Snyder, P.M., Wemmie, J.A., Welsh, M.J.: Oxidant Regulated Inter-subunit Disulfide Bond formation Between ASIC1a Subunits. Proc. Natl. Acad., 106(9):3573-3578, 2009.
- Collier, D.M., Snyder, P.M.: Extracellular Chloride Regulates the Epithelial Sodium Channel. J. Biol. Chem., 284(43):29320-293205, 2009.
- Snyder PM. Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2. Sci Signal. 2009 Jul 14;2(79):pe41.
- Collier, D.M., and Snyder, P.M.: Extracellular Protons Regulate Human ENaC by Modulating Na+ Self-inhibition. J. Biol. Chem., 284(2):792-8, 2009.
- Kabra, R., Knight, K.K., Zhou, R., and Snyder, P.M.: Nedd4-2 Induces Endocytosis and Degradation of Proteolytically Cleaved Epithelial Na+ Channels. J. Biol. Chem., 283:6033-6039, 2008.
- Knight, K.K., Wentzlaff, D.M., and Snyder, P.M.: Intracellular Sodium Regulates Proteolytic Activation of the Epithelial Sodium Channel. J. Biol. Chem., 283(41):27477-82, 2008.
- Zhou, R., Patel, S.V., and Snyder, P.M.: Nedd4-2 Catalyzes Ubiquitihation and Degradation of Cell Surface ENaC. J. Biol. Chem., 282:20207-20212, 2007.
- Knight, K.K., Olson, D.R., Zhou, R., and Snyder, P.M.: Liddle's Syndrome Mutations Increase Na+ Transport Through Dual Effects on Epithelial Na+ Channel Surface Expression and Proteolytic Cleavage. Proc. Nat'l. Acad. Sci. U.S.A>, 103:2805-2808, 2006.
- Zhou, R. and Snyder, P.M.: Nedd4-2 Phosphorylation Induces Serum and Glucocorticoid-Regulated Kinase (SGK) Ubiquitination and Degradation. J. Biol. Chem., 280:4518-4523, 2005.
- Snyder, P.M.: Regulation of Epithelial Na+ Channel Trafficking. Endocrinology, 106:5079-5085, 2005.
- Snyder, P.M., Olson, D.R., Kabra, R., Ahou, R., Steines, J.C.: cAMP and Serum and Glucocorticoid-Regulated Kinase (SGK) Regulate the Epithelial Na(+) Channel Through Convergent Phosphorylation of Nedd4-2. J. Biol. Chem., 279:45753-45758, 2004.
Links of Interest