Department of Internal Medicine

Cardiovascular Medicine Faculty

Mark E. Anderson, M.D., Ph.D.
Professor of Medicine and Physiology
Potter-Lambert Chair and Director of Cardiology

Dr. Anderson is clinically trained as a cardiac electrophysiologist. His research is focused on cellular signaling and ionic mechanisms that cause heart failure and sudden cardiac death. The multifunctional Ca2+/calmodulin dependent protein kinase II (CaMKII) is upregulated in heart disease and arrhythmias. Work in the Anderson laboratory implicates CaMKII as a signal that drives myocardial hypertrophy, apoptosis, mechanical dysfunction and electrical instability. The laboratory work ranges from molecular structure activity analysis of CaMKII to systems physiology using genetically modified mice to dissect cellular mechanisms of CaMKII signaling in heart.

Honors, Awards, and Organizations

American Society of Clinical Investigation
Established Investigator, American Heart Association
Association of American Physicians

Mark Anderson photo

Medical School:
University of Minnesota

Residency:
Stanford University

Fellowship:
Stanford University

Recent Publications

Zhang, R., Khoo, M.S.C., Wu, Y., Dzhura, I., Ni, G., Vishnivetskaya, T.A., Grueter, C., Madu, E.C., Gurevich, V.V., Colbran, R.J., Anderson, M.E. Calmodulin kinase II inhibition protects against structural heart disease. Nature Med., 2005; 11:409-417. Published with accompanying editorial.
Zhang, R., Dzhura, I., Grueter, C., Thiel, W., Colbran, R.J., Anderson, M.E. A dynamic a-b inter-subunit agonist signal-ing complex is a novel feedback mechanism for regulating L-type Ca2+ channel opening. FASEB J., 2005; 10.1096/fj.04-3283fje.
Khoo, M.S.C., Kannankeril, P.J., Li, J., Zhang, R., Kupershmidt, S., Zhang, W., Atkinson, J.B., Colbran, R.J., Roden, D.M., Anderson, M.E. Calmodulin kinase II activity is required for normal atrioventricular nodal conduction. Heart Rhythm. 2005; 2:634-640. Published with accompanying editorial.
Chad E. Grueter, Sunday A. Abiria, Igor Dzhura, Yuejin Wu, Amy-Joan Hamm, Peter J. Mohler, Mark E. Anderson, Roger J. Colbran. Molecular basis for facilitation of native Ca2+ channels by CaMKII. Accepted for Publication. Molecular Cell. (Anderson and Colbran are co-corresponding authors) 2006.
Yingbo Yang, Rong Zhang, Chad Grueter, Mark E. Anderson. Calmodulin kinase inhibition protects against myocardial apoptosis in vivo: excitation-apoptosis coupling Am J Physiol 2006 Accepted for publication.
Michelle S.C. Khoo, Rong Zhang, Gemin Ni, Chad Grueter, Yingbo Yang, Wei Zhang, Lisa Mendes, Eric N. Olson, Roger J. Colbran, Mark E. Anderson. Death, cardiac dysfunction and arrhythmias due to up-regulation of calmodulin kinase II in calcineurin-induced cardiomyopathy Accepted for publication Circulation 2006.

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