Department of Internal Medicine

Cardiovascular Medicine Faculty

Long-Sheng Song

Medical School:
North China Coal Medical College
Tangshan, Hebei, China

Fellowship:
National Institute on Aging, NIH

Long-Sheng Song, M.D., M.S.
Assistant Professor

Dr. Song's research interests include gene regulation of Ca2+-signaling in cardiac excitation-contraction coupling; the cellular and molecular mechanisms of Ca2+-dependent arrhythmias during heart failure, and the roles of Ca2+ signaling dysfunction in other heart diseases.

Honors, Awards, and Organizations

Recent Publications

  1. Chen B, Wu Y, Mohler PJ, Anderson ME, Song LS. Local control of Ca(2+)-induced Ca(2+) release in mouse sinoatrial node cells. J Mol Cell Cardiol. 2009 Jul 15. [Epub ahead of print]
  2. Lehnart, S.E., Terrenoire, C., Reiken, S., Song, L.-S., Wehrens, X.H., Tillman, E.J., Mancarella, S., Cervantes, D., Coromillas, J., Lederer, W.J., Kass, R.S., and Marks, A.R. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci USA 2006, 103: 7906-7910.
  3. Song, L.-S., Sobie, E.A., McCulle, S., Lederer, W.J., Balke, C.W., and Cheng, H. Orphaned RyRs in the failing heart. Proc Natl Acad Sci USA, 103:4305-4310, 2006.
  4. Song, L.-S., Pi, Y.Q., Kim, S.J., Yatani, A., Guatimosim, S., Kudej, R.K., Zhang, Q., Cheng, H., Hittinger, L., Ghaleh, B., Vatner, D.E., Lederer, W.J., and Vatner, S.F. Paradoxical cellular Ca2+ signaling in compensated canine left ventricular hypertrophy. Circ Res, 97:457-464, 2005.
  5. Laure H, Song L-S, Molinski TF, Pessah IN, Cheng H, and Russell JT: Sparks and puffs in oligodendrocyte progenitor: Crosstalk between ryanodine receptors and IP3 receptors. J Neurosci, 21(11):3860-3870, 2001.
  6. Song L-S, Guia A, Muth JN, Wang S-Q, Rubio M, Xiao R-P, Josephson IR, Lakatta EG, Schwartz A, and Cheng H: Ca2+ signaling in cardiac myocytes overexpressing the a1 subunit of L-type Ca2+ channel. Circ Res, 90(2):174-181, 2002.
  7. Wang S-Q, Song L-S, Xu L, Messner G, Lakatta EG, Rios E, Stern M, and Cheng H: Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca2+ sparks. Biophys J, 83(1):242-251, 2002.
  8. Mohler PJ, Schott JJ, Gramolini AO, Dilly KW, Guatimosim S, duBell WH, Song L-S, Haurogne K, Kyndt F, Ali ME, Rogers TB, Lederer WJ, Escande D, Marec HL, and Bennett V: Ankyrin-B mutation causes type 4 long QT cardiac arrhythmia and sudden cardiac death. Nature, 421:634-639, 2003.
  9. Yang D, Song L-S, Zhu W, Chakir K, Wang W, Wu C, Wang Y, Xiao R-P, Chen SR, and Cheng H: Calmodulin regulation of excitation-contraction coupling in cardiac myocytes. Circ Res, 92(6):659-667, 2003.
  10. Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song L-S, Rosemblit N, D’Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, and Marks AR: FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell, 113(7):829-840, 2003.
  11. Shen, J-X, Wang SQ, Song L-S, Han T, and Cheng H: Polymorphism of Ca2+ sparks evoked from in-focus Ca2+ release units in cardiac myocytes. Biophys J, 86(1):182-190, 2004.
  12. Chen B, Cai J, Song L-S, Wang X, and Chen Z: Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes. Life Sci, 76:1111-1121, 2005.
  13. Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, Price EE Jr., Thiel W, Guatimosim S, Song L-S, Madu EC, Shah AN, Vishnivetskaya TA, Atkinson JB, Gurevich VV, Salama G, Lederer WJ, Colbran RJ, and Anderson ME: Calmodulin kinase II inhibition protects against structural heart disease: A novel approach for selectively targeting pathological responses to ß-adrenergic receptor signaling. Nature Med, 11:409-417, 2005.
  14. Sobie EA, Song L-S, and Lederer WJ: Local recovery of Ca2+ release in rat ventricular myocytes. J Physiol, 565:441-447, 2005.
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