Department of Internal Medicine
Cardiovascular Medicine Faculty
Isabella M. Grumbach, M.D., Ph.D.
Dr. Grumbach's clinical and research interests are non-invasive imaging and general cardiology. Her research interests focus on signaling pathways that regulate inflammation and hypertrophy in vascular disease. Studies are directed at understanding the interaction of different agonists in the activation of NF-kB in vascular smooth muscle cells and blood vessels.
Honors, Awards, and Organizations
- Merck, Sharp & Dohme Research Award, 1997
- Vascular Biology Working Group Fellowship 2002
- American Heart Association, Postdoctoral Fellowship 2003
- American College of Cardiology
- American Heart Association
- Diplomat of the American College of Physicians/ American Society of Internal Medicine
- 1. Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009 ;106:5972-7 PMCID: 2667018
- 2. Li H, Li W, Gupta AK, Mohler PJ, Anderson ME, Grumbach IM. Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H688-98. Epub 2009 Dec 18. PMID: 20023119
- 3. Koval OM, Guan X, Wu Y, Joiner ML, Gao Z, Chen B, Grumbach IM, Luczak ED, Colbran RJ, Song LS, Hund TJ, Mohler PJ, Anderson ME. CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4996-5000. Epub 2010 Mar 1. PMID: 20194790
- 4. Li W, Li H, Sanders PN, Mohler PJ, Backs J, Olson EN, Anderson ME, Grumbach IM. The multifunctional Ca2+/calmodulin-dependent kinase IId (CaMKIId) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle regulation by p21. J Biol Chem. 2011 Mar 11; 286 (10): 7990-7999. Epub 2010 Dec 30. PMID: 21193397
- 5. Swaminathan PD, Purohit A, Soni S, Voigt N, Singh M, Glukhov A, Gao Z, He J, Luczak E, Joiner M,
- Kutschke W, Yang J, Donahue JK, Weiss R, Grumbach IM, Ogawa M, Chen P-S, Efimov IR, Dobrev D,
- Mohler P, Hund T, Anderson ME. Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J.Clin. Invest., 2011 (accepted). Published with an accompanying editorial.