Dr. Grumbach's clinical and research interests are non-invasive imaging and general cardiology. Her research interests focus on signaling pathways that regulate inflammation and hypertrophy in vascular disease. Studies are directed at understanding the interaction of different agonists in the activation of NF-kB in vascular smooth muscle cells and blood vessels.

Honors, Awards, and Organizations

• Merck, Sharp & Dohme Research Award, 1997
• Vascular Biology Working Group Fellowship 2002
• American Heart Association, Postdoctoral Fellowship 2003
• American College of Cardiology
• American Heart Association
• Diplomat of the American College of Physicians/ American Society of Internal Medicine

Recent Publications

1. Davis, M.E., Grumbach, I.M., Hutchins, A., Fukai, T., Harrison, D.G. Shear Stress Regulates Endothelial Nitric Oxide Synthase Promoter Activity Through Nuclear Factor Kappa-B Binding J Biol Chem 2004: 279(1):163-8.
2. Grumbach, I.M., Mertens, S.A., Harrison, D.G. A Negative Feedback Mechanism Involving Nitric Oxide and Nuclear Factor Kappa-B Modulates Endothelial Nitric Oxide Synthase Transcription. J Mol Cell Cardiol. 2005;39: 595-603.
3. Harrison, D.G., Widder, J., Grumbach, I.M., Chen, W., Weber, M., Searles, C. Endothelial mechanotransduction, nitric oxide and vascular inflammation. J Intern Med. 2006;259: 351-63.

Medical School:
Ruhr University Medical School, Bochum, Germany

Residency:
Georg August University Göttingen, Germany
Cook County Hospital, Chicago

Fellowship:
University of Illinois
Emory University