Department of Internal Medicine

Cardiovascular Medicine Faculty

  Additional Publications

1. Toyoda, K., Faraci, F.M., Russo, A.J., Davidson, B.L., and Heistad, D.D.: Gene Transfer of Calcitonin Gene-Related Peptide to Cerebral Arteries. Am. J. Physiol.: Heart, 278:H586-594, 2000.
2. Lentz, S.R., Piegors, D., Malinow, M.R., and Heistad, D.D.: Supplementation of Atherogenic Diet with B Vitamins Does Not Prevent Atherosclerosis or Vascular Dysfunction in Monkeys. Circulation 103:1006-1011, 2001.
3. Heistad, D.D.: Gene Transfer to Blood Vessels: A Research Tool and Potential Therapy. Am. J. Hypertens., 14:28S-32S, 2001.
4. Gunnett, C.A., Lund, D.D., Chu, Y., Brooks, R.M., Faraci, F.M., and Heistad, D.D.: NO-Dependent Vasorelaxation is Impaired After Gene Transfer of Inducible NO Synthase. Arterioscler. Thromb. Vasc. Biol., 21:1281-1287, 2001.
5. Nakane,H., Chu, Y., Faraci, F.M., Oberley, L.W., and Heistad, D.D.: Gene Transfer of ECSOD Increases SOD Activity in Cerebrospinal Fluid. Stroke, 32:184-189, 2001.
6. Chu, Y., Heistad, D.D., Cybulsky, M.I., and Davidson, B.L. Vascular Cell Adhesion Molecule-1 (VCAM-1) Augments Adenovirus-Mediated Gene Transfer. Arterioscler. Thromb. Vasc. Biol., 21:238-242, 2001.
7. Didion, S.P., Heistad, D.D., and Faraci, F.M.: Mechanisms that Produce Nitric Oxide-Mediated Relaxation of Cerebral Arteries During Atherosclerosis. Stroke, 32:761-766, 2001.
8. Lentz, S.R., Piegors, D., Malinow, M.R., and Heistad, D.D.: Supplementation of Atherogenic Diet with B Vitamins Does Not Prevent Atherosclerosis or Vascular Dysfunction in Monkeys. Circulation 103:1006-1011, 2001.
9. Dayal, S., Bottiglieri, T., Arning, E., Maeda, N., Malinow, M.R., Heistad, D.D., Faraci, F.M., Lentz, S.R.: Endothelial Dysfunction and Elevation of S -Adenosylhomocysteine in Cystathione b -Synthase-Deficient Mice. Circ. Res., 88:1203-1209, 2001.
10. Faraci, F.M., Sobey, C.G., Chrissobolis, Lund, D.D., Heistad, D.D., and Weintraub, N.L.: Arachidonate Dilates the Basilar Artery by a Lipoxygenase-Dependent Mechanism and Activation of K+ Channels. Am. J. Physiol.: Reg., 281:R246-R253, 2001.
11. Gunnett, C.A., Lund, D.D., Chu, Y., Brooks, R.M., Faraci, F.M., and Heistad, D.D.: NO-Dependent Vasorelaxation is Impaired After Gene Transfer of Inducible NO Synthase. Arterioscler. Thromb. Vasc. Biol., 21:1281-1287, 2001.
12. Toyoda, K., Nakane, H., Faraci, F.M., and Heistad, D.D.: Cationic Polymer and Lipids Augment Adenovirus-Mediated Gene Transfer to Cerebral Arteries In Vivo. J. Cereb. Blood Flow Metab., 21:1125-1131, 2001.
13. Heistad, D.D.: "Landis Award: What's New in the Cerebral Circulation?" Microcirculation, 8:365-375, 2001.
14. Satoh, M., Perkins, E., Kimura, H., Tang, J., Chu, Y., Heistad, D.D., and Zhang, J.H.: Post-Treatment with Adenovirus-Mediated Calcitonin Gene-Related Peptide Gene Transfer Reverses Cerebral Vasospasm in Dogs. Neurosurgery (in press).
15. Lentz, S.R., Miller, F.M. Jr., Piegors, D, and Heistad, D.D.: Impaired Anticoagulant Response to Thrombin Improve During Regression of Atherosclersosis in Monkeys. Circulation, 106:842-846, 2002.
16. Hathaway, C., Heistad, D.D., Piegors, D.J., and Miller, F.M.: Regression of Atherosclerosis in Monkeys Reduces Vascular Superoxide Levels. Circ. Res. 90: 277-283, 2002.
17. Chu, Y., Heistad, D.D., Knudtson, K.L., Lamping, K.G., and Faraci F. M.: Quantification of mRNA for Endothelial Nitric Oxide Synthase in Mouse Blood Vessels: Real-time Polymerase Chain Reaction. Arterioscler., Thromb., Vasc. Biol., 22:611-616, 2002.
18. Lentz, S.R., Miller, F.M. Jr., Piegors, D.J., Erger, R.A., Fernández, J.A., Griffin, J.H., and Heistad, D.D.: Anticoagulant Responses to Thrombin are Enhanced During Regression of Atherosclerosis in Monkeys. Circulation, 106:842-846, 2002.
19. Gunnett, C.A., Heistad, D.D., and Faraci, F.M.: Interleukin-10 Protects Nitric Oxide-Dependent Relaxation During Diabetes: Role of Superoxide. Diabetes, 51:1931-1937, 2002.
20. Satoh, M., Perkins, E., Kimura, H., Tang, J., Chu, Y., Heistad, D.D., and Zhang, J.H.: Post-Treatment with Adenovirus-Mediated Calcitonin Gene-Related Peptide Gene Transfer Reverses Cerebral Vasospasm in Dogs. J. Neurosurgery, 97:136-142, 2002.
21. Gunnett, C.A., Lund, D.D., Howard, M.A., Chu, Y., Faraci, F.M., and Heistad, D.D.: Gene Transfer of Inducible Nitric Oxide Synthase Impairs Relaxation in Human and Rabbit Cerebral Arteries. Stroke, 33:2292-2296, 2002.
22. Lentz, S.R., Piegors, D., Fernandez, J.A., Erger, R.A., Arning, E., Malinow, M.R., Griffin, J.H., Bottiglieri, T., Haynes, W.G., and Heistad, D.D.: Effect of Hyper-homocysteinemia on Protein C Activation and Activity. Blood, 100:2108-2112, 2002.
23. Watanabe, Y., Chu, Y., Andresen, J.A., Nakane, H., Faraci, F.M., and Heistad, D.D.: Gene Transfer of Extracellular Superoxide Dismutase Reduces Vasospasm After Subarachnoid Hemorrhage. Stroke, 34:434-440, 2003.
24. Toyoda, K., Chu, Y., and Heistad, D.D.: Gene Therapy for Cerebral Vascular Disease: Update 2003. Brit. J. Pharmacol., 139:1-9, 2003.
25. Heistad, D.D.: Mikamo Lecture: A Radical View of the Superfamily of Cardiovas-cular Risk Factors. Circulation J. 67:805-809, 2003.
26. Li, L., Chu, Y., Fink, G.D., Engelhardt, J.F., Heistad, D.D., and Chen, A.F.: Endothelin-1 Stimulates Arterial VCAM-1 Expression via NADPH Oxidase-Derived Superoxide in Mineralocorticoid Hypertension. Hypertension, 42:997-1003, 2003.
27. Gunnett, C.A., Heistad, D.D., and Faraci, F.M.: Gene-Targeted Mice Reveal a Critical Role for Inducible Nitric Oxide Synthase in Vascular Dysfunction During Diabetes. Stroke, 34:2970-2974, 2003.
28. Lund, D.D., Gunnett, C.A., Chu, Y., Brooks, R.M., Faraci, F.M., and Heistad, D.D.: Gene Transfer of Extracellular Superoxide Dismutase Improves Relaxation of Aorta After Treatment with Endotoxin. Am. J. Physiol.:Heart, 56:H805-H811, 2004.
29. Chu, Y., Iida, S., Lund, D.D., Weiss, R.M., DiBona, G.F., Watanabe, Y., Faraci, F.M., and Heistad, D.D.: Gene Transfer of Extracellular Superoxide Dismutase Reduces Arterial Pressure in Spontaneously Hypertensive Rats: Role of Heparin Binding Domain. Circ. Res., 92:461-468, 2003.
30. Heistad, D.D.: Perspective: Unstable Coronary Artery Plaques. New Engl. J. Med., 349:2285-2287, 2003.
31. Durham, P.L., Dong, P.X., Belasco, K.T., Kasperski, J., Gierasch, W.W., Edvinsson, L., Heistad, D.D., Faraci, F.M., and Russo, A.R.: Neuronal Expression and Regulation of CGRP Promoter Activity Following Viral Gene Transfer into Cultured Trigeminal Ganglia Neurons. Brain Res., 997:103-110, 2004.
32. Andresen, J.J., Faraci, F.M., and Heistad, D.D.: Vasomotor Responses in MnSOD-deficient Mice. Am. J. Physiol.: Heart, 56:H1141-H1148, 2004.
33. Yamaguchi, M., Zhou, C., Heistad, D.D., Watanabe, Y., and Zhang, J.H.: Gene Transfer of Extracellular Superoxide Dismutase Failed to Prevent Cerebral Vaso-spasm After Experimental Subarachnoid Hemorrhage. Stroke, 35:2512-2517, 2004.
34. Watanabe, Y, and Heistad, D.D.: Targeting Cerebral Arteries for Gene Therapy. Exp. Physiol.: Transl. Integration, 90:327-331, 2005.
35. Watanabe, Y., Faraci, F.M., and Heistad, D.D.: Activation of Rho-Associated Kinase During Augmented Contraction of the Basilar Artery to Serotonin After Subarachnoid Hemorrhage. Am. J. Physiol. Heart, 288:H2653-H2658, 2005.
36. Iida, S., Baumbach, G.L., Lavoie, J.L., Faraci, F.M. Sigmund, C.D., and Heistad, D.D.: Spontaneous Stroke in a Genetic Model of Hypertension in Mice. Stroke, 36:1253-1258, 2005.
37. Iida, S., Francis, J., Chu, Y., Weiss, R.M., Gunnett, C.A., Faraci, F.M., and Heistad, D.D.: Gene Transfer of ECSOD Improves Endothelial Function in Rats with Heart Failure. Am. J. Physiol.: Heart, 289:H525-532, 2005.
38. Gunnett, C.A., Lund, D.D., Faraci, F.M., and Heistad, D.D.: Vascular Interleukin-10 Protects Against LPS-Induced Vasomotor Function. Am. J. Physiol.: Heart, 289:H624-H630, 2005.
39. Gunnett, C.A., Lund, D.D., McDowell, A., Faraci, F.M., and Heistad, D.D.: Mechanisms of iNOS Mediated Vascular Dysfunction. Arterioscler. Thromb. Vasc. Biol., 25:1617-1622, 2005.
40. Chu, Y., Alwahdani, A., Iida, S., Lund, D.D., Faraci, F.M., and Heistad, D.D.: Vascular Effects of Human Extracellular SODR213G Variant. Circulation, 112:1047-1053, 2005.
41. Ohashi, M., Faraci, F.M., and Heistad, D.D.: Peroxynitrite Hyperpolarizes Smooth Muscle and Relaxes Internal Carotid Artery in Rabbit via ATP-Sensitive K+ Chan-nels. Am. J. Physiol.: Heart, 289:H2244-H2250, 2005.
42. Sethi, S., Iida, S., Sigmund, C.D., and Heistad, D.D.: Renal Thrombotic Microangiopathy in a Genetic Model of Hypertension in Mice. Exp. Biol. Med., 231:196-203, 2006.
43. Heistad, D.D. Duff Lecture: Oxidative Stress and Vascular Disease. Arterioscler. Thromb. Vasc. Biol., 26:689-695, 2006.
44. Brown, K.A., Chu, Y., Lund, D.D., Heistad, D.D., and Faraci, F.M.: Gene Transfer of Extracellular Superoxide Dismutase Protects Against Vascular Dysfunction with Aging. Am. J. Physiol., 290:H2600-H2605, 2006.
45. Iadecola, C., Goldman, S.S., Harder, D.R., Heistad, D.D., Katusic, Z.S., Moskowitz, M.A., Simard, J.M., Sloan, M.A., Traystman, R.J., and Velletri, P.A. Recommendations of the National Heart, Lung, and Blood Institute Working Group on Cerebrovascular Biology and Disease. Stroke, 37:1578-1581, 2006.

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