Department of Internal Medicine
Cardiovascular Medicine Faculty
Medical School:
Ain Chams University, Egypt
Residency:
Milwaukee County Hospital
Fellowship:
Marquette University
The University of Iowa
François M. Abboud, M.D.
Edith King Pearson Chair in Cardiovascular Research
Professor of Medicine and Molecular Physiology and Biophysics
Associate Vice President for Research
Founding Director, UI Cardiovascular Research Center (1974-2012)
Former Head, Department of Internal Medicine (1976-2002)
Research interests are directed toward the neural regulation of the circulation and its translational significance in hypertension. Specific studies examine the cellular and molecular mechanisms of baroreceptor and chemoreceptor activation, and the role of mechanosensitive and chemosensitive ion channels in isolated neurons and glomus cells, and in transgenic mice.
Human studies have focused on the integrated control of sympathetic activity in physiologic and pathologic states (e.g., sleep apnea and hypertension).
Dr. Abboud directs an interdisciplinary cardiovascular research training program and a Program Project Grant on The Integrative Neurobiology of Cardiovascular Regulation since 1971. He was the founding director of the Cardiovascular Research Center from 1974-2012.
Honors, Awards, and Organizations
- American Association for the Advancement in Sciences
- American Medical Association
- American Association for University Professors
- Society of the Sigma XI
- American College of Physicians (Master,1991)
- American Society for Experimental Biology and Medicine, 1962 (Council, 2003-2008)
- Association of University Cardiologists
- American Society for Clinical Investigation (President-Elect nominee 1976)
- American College of Cardiology (Distinguished Scientist Award in Basic Science, 2004)
- Association Patient-Oriented Research (Founding Member, 2000)
- ASPET Award for Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 1972
- Alpha Omega Alpha (Honorary)
- Award for Outstanding Work in Science as related to Medicine of American College of Physicians-American Society of Internal Medicine, 2000
- Carl Ludwig Distinguished Lecturer (American Physiological Society), 2000
- Research Achievement Award of American Heart Association, 1999
- American Academy of Arts and Sciences, 1997 (Regional Council, 2003), Membership Committee Chair Class II (Biological Sciences) 2002-2004
- Advisory Council National Heart Lung & Blood Institute, 1995-99
- Gold Heart Award, American Heart Association, 1995
- Honorary Doctor of Science, Medical College of Wisconsin, 1994
- Robert H. Williams Distinguished Chairman of Medicine Award, Association of Professor of Medicine, 1993
- Frances Gilman Blake Award, Association of American Physicians, 1992
- Distinguished Service Award, Central Society for Clinical Research, 1992
- Doctor Honoris Causa diploma, University of Lyon, France, 1991
- President, National American Heart Association, 1990-91
- President, Association of American Physicians, 1990-91
- CIBA Award for Hypertension Research, 1990
- Carl J. Wiggers Award (American Physiological Society), 1988
- Institute of Medicine (National Academy of Sciences), 1988 (Nominating Committee, 1994-1999), Chair Section 4
- President, Central Society for Clinical Research, 1986
- Editor-in-Chief, Circulation Research (American Heart Association), 1981-86
- Co-Editor, Handbook of Physiology: Peripheral Circulation & Organ Blood Flow, (American Physiological Society), 1983
- Editor, Neurogenic Control of the Circulation (American Physiological Society), 1982
- Editorial Advisory Board, Clinical Autonomic Research, 1990
- Editor-in-Chief, Proceedings of the Association of American Physicians, 1995-99
- Associate Editor, Physiology in Medicine (Annals of Internal Medicine), 2000-2005
- Associate Editor, Advances in Internal Medicine, 1991-96
- Consulting Editor, Circulation Research, 1991-
- Associate Editor, Hypertension, American Heart Association, 1989-90
- Editorial Board, Medicine, 1992-
- Editorial Board, American Journal of Physiology, 1976-81
- Editorial Board, Journal of Clinical Investigation, 1971-76
- Editorial Board, Journal of Laboratory and Clinical Medicine, 1969-73
- Associate Editor, Journal of Laboratory and Clinical Medicine, 1970-73
- President, American Federation for Clinical Research, 1971
- Distinguished Scientist Award (American Heart Association), 2007
- Walter B. Cannon Award and Lecturer (American Physiological Society), 2009
- Kober Medal, Association of American Physicians, 2009
- Ben Qurrah Award, Arab American Medical Association, Houston, 2010
Selected Publications
- Li, Z., Chapleau, M.W., Bates, J.N., Bielefeldt, K., Lee, H-C, and Abboud, F.M.: Nitric Oxide as an Autocrine Regulator of Sodium Currents in Baroreceptor Neurons. Neuron, 20:1039-1049,1998.
- Somers, V.K., Dyken, M.E., Clary, M.P., and Abboud, F.M.: Sympathetic Neural Mechanisms in Obstructive Sleep Apnea. J. Clin. Invest., 96:1897-1904, 1995.
- Drummond, H.A., Price, M.P., Welsh, M.J., and Abboud, F.M.: A Molecular Component of the Arterial Baroreceptor Mechanotransducer. Neuron, 21:1435-1441, 1998.
- Bielefeldt, K., Whiteis, C.A., Chapleau, M.W., and Abboud, F.M.: Nitric Oxide Enhances Slow Inactivation of Voltage-Dependent Sodium Currents in Rat Nodose Neurons. Neurosci. Lett., 271(3):159-162, 1999.
- Yermolaiva, O., Leonard, A.S., Schnizler, M.K., Abboud, F.M., Welsh, M.J.: Extracellular Acidosis Increases Neuronal Cell Calcium by Activating Acid-Sensing Ion Channel 1a. PNAS 101(17):6752-6757, 2004 Apr 27.
- Snitsarev, V., Whiteis, C.A., Chapleau, M., and Abboud, F.M.: Neuronal Prostacyclin is an Autocrine Regulator of Arterial Baroreceptor Activity. Hypertension, 46 (3):540-546, 2005 Sept.
- Snitsarev, V., Whiteis, C.A., Chapleau, M.W., and Abboud, F.M.: Mechano- And Chemo-sensitivity of Rat Nodose Neurones – Selective Excitatory Effects of Prostacyclin. J Physiol, 582(1):177-194, 2007.
- Tan, Z., Lu, Y., Whiteis, C.A., Benson, C., Chapleau, M.W., and Abboud, F.M.: Acid Sensing Ion Channels (ASICs) Contribute to Transduction of Extracellular Acidosis in Rat Carotid Body Glomus Cells. Circ. Res. 101:1009-1019, 2007.
- Hattori T, Chen J, Harding AM, Price MP, Lu Y, Abboud FM, Benson CJ. ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons. Circ Res. 2009 Jul 31;105(3):279-86. Epub 2009 Jul 9.
- Lu, Y., Ma, X., Sabharwal, R., Snitsarev, V., Morgan, D., Rahmouni, K., Drummond, H., Whiteis, C., Costa, V., Price, M., Benson, C., Welsh, M.J., Chapleau, M.W., and Abboud, F.M.: The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation. Neuron 64(6):885-97, 2009. PMC2807410.
- Tan, Z.Y., Lu, Y., Whiteis, C.A., Simms, A., Paton, J.F.R., Chapleau, M., Abboud, F.M.: Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR. Circ. Res. 106:536-545, 2010. PMC2846115.
- Abboud, F.M.: Walter B. Cannon Award Lecture, 2009, Physiology in Perspective: The Wisdom of the Body: In Search of Autonomic Balance: The Good, the Bad and the Ugly. Am J Physiol Regul Integr Comp Physiol. 298:1449-1467, 2010.
- Abboud, F.M., Harwani, S.C., and Chapleau, M.W.: Autonomic Neural Regulation of the Immune System: Implications for Hypertension and Cardiovascular Disease. Hypertension vol. 59:755-62, 2012.
- Harwani, S., Chapleau, M.W., Legge, K.L., Ballas, Z.K., and Abboud, F.M.: Neurohumoral Regulation of the Innate Immune Response is Pro-inflammatory in the Pre-hypertensive Spontaneously Hypertensive Rat, A. Genetic Model of Essential Hypertension. Circ. Res. (Published online, 2012.)
- Petroff, E., Snitsarev, V., Gong, H., Abboud, F.M.: Acid Sensing Ion Channels Regulate Neuronal Excitability by Inhibiting BK Potassium Channels. Biochem. and Biophys. Res Communications (BBRC). (Published online, 2012.)
- Lu, Y., Whiteis, C., Sluka, K.A., Chapleau, M.W., and Abboud, F.M.: Responses of Carotid Body Glomus Cells to Hypoxia and Acidosis are Uncoupled, and Linked to ASIC3 Expression. J. Physiol. (Submitted, 2012.)
Links of Interest