Department of Internal Medicine
Cardiovascular Medicine Faculty
Medical School:
Aims Chams University, Egypt
Residency:
Milwaukee County Hospital
Fellowship:
Marquette University
The University of Iowa
Francois M. Abboud, M.D.
Edith King Pearson Chair in Cardiovascular Research
Professor of Medicine and Molecular Physiology and Biophysics
Director, Cardiovascular Research Center
Associate Vice President for Research
Former Head, Department of Internal Medicine (1976-2002)
Research interests are directed toward the neural regulation of the circulation. Specific studies examine the cellular and molecular mechanisms of mechanical activation of baroreceptor neurons and the role of stretch-activated ion channels in the generation of baroreceptor nerve activity in isolated neurons and in transgenic mice.
Human studies have focused on the integrated control of sympathetic activity in physiologic and pathologic states (e.g., sleep apnea and hypertension).
Dr. Abboud directs an interdisciplinary cardiovascular research training program and a Program Project Grant on Integrative Functions in Neurovascular Control, now in its 38th year. He has been director of the Cardiovascular Research Center since 1974.
Honors, Awards, and Organizations
- American Association for the Advancement in Sciences
- American Medical Association
- American Association for University Professors
- Society of the Sigma XI
- American College of Physicians (Master,1991)
- American Society for Experimental Biology and Medicine, 1962 (Council, 2003-2008)
- Association of University Cardiologists
- American Society of Clinical Investigation
- American College of Cardiology (Distinguished Scientist Award in Basic Science, 2004)
- Associate Editor Physiology in Medicine ( Annals of Internal Medicine ), 2002-2005
- Association Patient-Oriented Research (Founding Member, 2000)
- ASPET Award for Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 1972
- Alpha Omega Alpha (Honorary)
- Award for Outstanding Work in Science as related to Medicine of American College of Physicians-American Society of Internal Medicine, 2000
- Carl Ludwig Distinguished Lecturer (American Physiological Society), 2000
- Research Achievement Award of American Heart Association, 1999
- American Academy of Arts and Sciences, 1997 (Regional Council, 2003)
- Advisory Council National Heart Lung & Blood Institute, 1995-99
- Gold Heart Award, American Heart Association, 1995
- Honorary Doctor of Science, Medical College of Wisconsin, 1994
- Robert H. Williams Distinguished Chairman of Medicine Award, Association of Professor of Medicine, 1993
- Frances Gilman Blake Award, Association of American Physicians, 1992
- Distinguished Service Award, Central Society for Clinical Research, 1992
- Doctor Honoris Causa diploma, University of Lyon, France, 1991
- President, American Heart Association, 1990-91
- President, Association of American Physicians, 1990-91
- CIBA Award for Hypertension Research, 1990
- Carl J. Wiggers Award (American Physiological Society), 1988
- Institute of Medicine (National Academy of Sciences), 1988
- President, Central Society for Clinical Research, 1986
- Editor-in-Chief, Circulation Research (American Heart Association), 1981-86
- Co-Editor, Handbook of Physiology: Peripheral Circulation & Organ Blood Flow, (American Physiological Society), 1983
- Editor, Neurogenic Control of the Circulation (American Physiological Society), 1982
- Editorial Advisory Board, Clinical Autonomic Research, 1990
- Editor-in-Chief, Proceedings of the Association of American Physicians, 1995-99
- Associate Editor, Advances in Internal Medicine, 1991-96
- Consulting Editor, Circulation Research, 1991-
- Associate Editor, Hypertension, American Heart Association, 1989-90
- Editorial Board, Medicine, 1992-
- Editorial Board, American Journal of Physiology, 1976-81
- Editorial Board, Journal of Clinical Investigation, 1971-76
- Editorial Board, Journal of Laboratory and Clinical Medicine, 1969-73
- Associate Editor, Journal of Laboratory and Clinical Medicine, 1970-73
- President, American Federation for Clinical Research, 1971
- Walter B. Cannon Award and Lecturer (American Physiological Society), 2009
- Kober Medal, Association of American Physicians, 2009
Selected Publications
- Li, Z., Chapleau, M.W., Bates, J.N., Bielefeldt, K., Lee, H-C, and Abboud, F.M.: Nitric Oxide as an Autocrine Regulator of Sodium Currents in Baroreceptor Neurons. Neuron, 20:1039-1049,1998.
- Somers, V.K., Dyken, M.E., Clary, M.P., and Abboud, F.M.: Sympathetic Neural Mechanisms in Obstructive Sleep Apnea. J. Clin. Invest., 96:1897-1904, 1995.
- Drummond, H.A., Price, M.P., Welsh, M.J., and Abboud, F.M.: A Molecular Component of the Arterial Baroreceptor Mechanotransducer. Neuron, 21:1435-1441, 1998.
- Bielefeldt, K., Whiteis, C.A., Chapleau, M.W., and Abboud, F.M.: Nitric Oxide Enhances Slow Inactivation of Voltage-Dependent Sodium Currents in Rat Nodose Neurons. Neurosci. Lett., 271(3):159-162, 1999.
- Yermolaiva, O., Leonard, A.S., Schnizler, M.K., Abboud, F.M., Welsh, M.J.: Extracellular Acidosis Increases Neuronal Cell Calcium by Activating Acid-Sensing Ion Channel 1a. PNAS 101(17):6752-6757, 2004 Apr 27.
- Snitsarev, V., Whiteis, C.A., Chapleau, M., and Abboud, F.M.: Neuronal Prostacyclin is an Autocrine Regulator of Arterial Baroreceptor Activity. Hypertension, 46 (3):540-546, 2005 Sept.
- Snitsarev, V., Whiteis, C.A., Chapleau, M.W., and Abboud, F.M.: Mechano- And Chemo-sensitivity of Rat Nodose Neurones – Selective Excitatory Effects of Prostacyclin. J Physiol, 582(1):177-194, 2007.
- Tan, Z., Lu, Y., Whiteis, C.A., Benson, C., Chapleau, M.W., and Abboud, F.M.: Acid Sensing Ion Channels (ASICs) Contribute to Transduction of Extracellular Acidosis in Rat Carotid Body Glomus Cells. Circ. Res. 101:1009-1019, 2007.
Links of Interest