Department of Internal Medicine

Cardiovascular Medicine Faculty

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Donald D. Heistad, M.D.
Zahn Professor of Cardiology (Internal Medicine and Pharmacology)

Dr. Heistad's clinical interests include general cardiology. His research interests focus on gene transfer to blood vessels, cerebral circulation, and vascular biology of atherosclerosis, hypertension, and diabetes.

Honors, Awards, and Organizations

• American Society for Clinical Investigation
• Association of American Physicians
• Association of University Cardiologists
• North American Vascular Biology Organization (Founding Member)
• Novartis Award, AHA Council for High Blood Pressure Research
• Carl Wiggers Award, American Physiological Society
• Distinguished Alumni Award, University of Chicago
• Editor-in-Chief, Arteriosclerosis, Thrombosis, and Vascular Biology
• Consulting Editor, Circulation Research and Circulation
• Eugene M. Landis Award, Microcirculatory Society
• Research Achievement Award, AHA

Recent Publications

1. Iida, S., Chu, Y., Weiss, R.M., Kang, Y-M., Faraci, F.M., and Heistad, D.D. Vascular Effects of a Common Gene Variant of Extracellular Superoxide Dismutase in Heart Failure. Am. J. Physiol: Heart, 291:H914-920, 2006.
2. Kitayama, J., Faraci, F.M., Gunnett, C.A., and Heistad, D.D. Impairment of Dilator Responses of Cerebral Arterioles During Diabetes Mellitus: Role of iNOS. Stroke, 37:2129-2133, 2006.
3. Chu, Y., Piper, R., Richardson, S., Watanabe, Y., Patel, P., and Heistad, D.D. Endocytosis of Extracellular Superoxide Dismutase into Endothelial Cells: Role of the Heparin-Binding Domain. Arterioscler. Thromb. Vasc. Biol., 26:1985-1990, 2006.
4. Toyoda, K., Faraci, F.M., Russo, A.J., Davidson, B.L., and Heistad, D.D.: Gene Transfer of Calcitonin Gene-Related Peptide to Cerebral Arteries. Am. J. Physiol.: Heart, 278:H586-594, 2000.
5. Lentz, S.R., Piegors, D., Malinow, M.R., and Heistad, D.D.: Supplementation of Atherogenic Diet with B Vitamins Does Not Prevent Atherosclerosis or Vascular Dysfunction in Monkeys. Circulation 103:1006-1011, 2001.
6. Heistad, D.D.: Gene Transfer to Blood Vessels: A Research Tool and Potential Therapy. Am. J. Hypertens., 14:28S-32S, 2001.
7. Gunnett, C.A., Lund, D.D., Chu, Y., Brooks, R.M., Faraci, F.M., and Heistad, D.D.: NO-Dependent Vasorelaxation is Impaired After Gene Transfer of Inducible NO Synthase. Arterioscler. Thromb. Vasc. Biol., 21:1281-1287, 2001.
8. Nakane,H., Chu, Y., Faraci, F.M., Oberley, L.W., and Heistad, D.D.: Gene Transfer of ECSOD Increases SOD Activity in Cerebrospinal Fluid. Stroke, 32:184-189, 2001.
9. Chu, Y., Heistad, D.D., Cybulsky, M.I., and Davidson, B.L. Vascular Cell Adhesion Molecule-1 (VCAM-1) Augments Adenovirus-Mediated Gene Transfer. Arterioscler. Thromb. Vasc. Biol., 21:238-242, 2001.
10. Didion, S.P., Heistad, D.D., and Faraci, F.M.: Mechanisms that Produce Nitric Oxide-Mediated Relaxation of Cerebral Arteries During Atherosclerosis. Stroke, 32:761-766, 2001.
11. Lentz, S.R., Piegors, D., Malinow, M.R., and Heistad, D.D.: Supplementation of Atherogenic Diet with B Vitamins Does Not Prevent Atherosclerosis or Vascular Dysfunction in Monkeys. Circulation 103:1006-1011, 2001.
12. Dayal, S., Bottiglieri, T., Arning, E., Maeda, N., Malinow, M.R., Heistad, D.D., Faraci, F.M., Lentz, S.R.: Endothelial Dysfunction and Elevation of S -Adenosylhomocysteine in Cystathione b -Synthase-Deficient Mice. Circ. Res., 88:1203-1209, 2001.
13. Faraci, F.M., Sobey, C.G., Chrissobolis, Lund, D.D., Heistad, D.D., and Weintraub, N.L.: Arachidonate Dilates the Basilar Artery by a Lipoxygenase-Dependent Mechanism and Activation of K+ Channels. Am. J. Physiol.: Reg., 281:R246-R253, 2001.
14. Gunnett, C.A., Lund, D.D., Chu, Y., Brooks, R.M., Faraci, F.M., and Heistad, D.D.: NO-Dependent Vasorelaxation is Impaired After Gene Transfer of Inducible NO Synthase. Arterioscler. Thromb. Vasc. Biol., 21:1281-1287, 2001.
15. Toyoda, K., Nakane, H., Faraci, F.M., and Heistad, D.D.: Cationic Polymer and Lipids Augment Adenovirus-Mediated Gene Transfer to Cerebral Arteries In Vivo. J. Cereb. Blood Flow Metab., 21:1125-1131, 2001.
16. Heistad, D.D.: "Landis Award: What's New in the Cerebral Circulation?" Microcirculation, 8:365-375, 2001.
17. Satoh, M., Perkins, E., Kimura, H., Tang, J., Chu, Y., Heistad, D.D., and Zhang, J.H.: Post-Treatment with Adenovirus-Mediated Calcitonin Gene-Related Peptide Gene Transfer Reverses Cerebral Vasospasm in Dogs. Neurosurgery (in press).
18. Lentz, S.R., Miller, F.M. Jr., Piegors, D, and Heistad, D.D.: Impaired Anticoagulant Response to Thrombin Improve During Regression of Atherosclerosis in Monkeys. Circulation, 106:842-846, 2002.
19. Hathaway, C., Heistad, D.D., Piegors, D.J., and Miller, F.M.: Regression of Atherosclerosis in Monkeys Reduces Vascular Superoxide Levels. Circ. Res. 90: 277-283, 2002.
20. Chu, Y., Heistad, D.D., Knudtson, K.L., Lamping, K.G., and Faraci F. M.: Quantification of mRNA for Endothelial Nitric Oxide Synthase in Mouse Blood Vessels: Real-time Polymerase Chain Reaction. Arterioscler., Thromb., Vasc. Biol., 22:611-616, 2002.
21. Lentz, S.R., Miller, F.M. Jr., Piegors, D.J., Erger, R.A., Fernández, J.A., Griffin, J.H., and Heistad, D.D.: Anticoagulant Responses to Thrombin are Enhanced During Regression of Atherosclerosis in Monkeys. Circulation, 106:842-846, 2002.
22. Gunnett, C.A., Heistad, D.D., and Faraci, F.M.: Interleukin-10 Protects Nitric Oxide-Dependent Relaxation During Diabetes: Role of Superoxide. Diabetes, 51:1931-1937, 2002.
23. Satoh, M., Perkins, E., Kimura, H., Tang, J., Chu, Y., Heistad, D.D., and Zhang, J.H.: Post-Treatment with Adenovirus-Mediated Calcitonin Gene-Related Peptide Gene Transfer Reverses Cerebral Vasospasm in Dogs. J. Neurosurgery, 97:136-142, 2002.
24. Gunnett, C.A., Lund, D.D., Howard, M.A., Chu, Y., Faraci, F.M., and Heistad, D.D.: Gene Transfer of Inducible Nitric Oxide Synthase Impairs Relaxation in Human and Rabbit Cerebral Arteries. Stroke, 33:2292-2296, 2002.
25. Lentz, S.R., Piegors, D., Fernandez, J.A., Erger, R.A., Arning, E., Malinow, M.R., Griffin, J.H., Bottiglieri, T., Haynes, W.G., and Heistad, D.D.: Effect of Hyper-homocysteinemia on Protein C Activation and Activity. Blood, 100:2108-2112, 2002.
26. Watanabe, Y., Chu, Y., Andresen, J.A., Nakane, H., Faraci, F.M., and Heistad, D.D.: Gene Transfer of Extracellular Superoxide Dismutase Reduces Vasospasm After Subarachnoid Hemorrhage. Stroke, 34:434-440, 2003.
27. Toyoda, K., Chu, Y., and Heistad, D.D.: Gene Therapy for Cerebral Vascular Disease: Update 2003. Brit. J. Pharmacol., 139:1-9, 2003.
28. Heistad, D.D.: Mikamo Lecture: A Radical View of the Superfamily of Cardiovascular Risk Factors. Circulation J. 67:805-809, 2003.
29. Li, L., Chu, Y., Fink, G.D., Engelhardt, J.F., Heistad, D.D., and Chen, A.F.: Endothelin-1 Stimulates Arterial VCAM-1 Expression via NADPH Oxidase-Derived Superoxide in Mineralocorticoid Hypertension. Hypertension, 42:997-1003, 2003.
30. Gunnett, C.A., Heistad, D.D., and Faraci, F.M.: Gene-Targeted Mice Reveal a Critical Role for Inducible Nitric Oxide Synthase in Vascular Dysfunction During Diabetes. Stroke, 34:2970-2974, 2003.
31. Lund, D.D., Gunnett, C.A., Chu, Y., Brooks, R.M., Faraci, F.M., and Heistad, D.D.: Gene Transfer of Extracellular Superoxide Dismutase Improves Relaxation of Aorta After Treatment with Endotoxin. Am. J. Physiol.:Heart, 56:H805-H811, 2004.
32. Chu, Y., Iida, S., Lund, D.D., Weiss, R.M., DiBona, G.F., Watanabe, Y., Faraci, F.M., and Heistad, D.D.: Gene Transfer of Extracellular Superoxide Dismutase Reduces Arterial Pressure in Spontaneously Hypertensive Rats: Role of Heparin Binding Domain. Circ. Res., 92:461-468, 2003.
33. Heistad, D.D.: Perspective: Unstable Coronary Artery Plaques. New Engl. J. Med., 349:2285-2287, 2003.
34. Durham, P.L., Dong, P.X., Belasco, K.T., Kasperski, J., Gierasch, W.W., Edvinsson, L., Heistad, D.D., Faraci, F.M., and Russo, A.R.: Neuronal Expression and Regulation of CGRP Promoter Activity Following Viral Gene Transfer into Cultured Trigeminal Ganglia Neurons. Brain Res., 997:103-110, 2004.
35. Andresen, J.J., Faraci, F.M., and Heistad, D.D.: Vasomotor Responses in MnSOD-deficient Mice. Am. J. Physiol.: Heart, 56:H1141-H1148, 2004.
36. Yamaguchi, M., Zhou, C., Heistad, D.D., Watanabe, Y., and Zhang, J.H.: Gene Transfer of Extracellular Superoxide Dismutase Failed to Prevent Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage. Stroke, 35:2512-2517, 2004.
37. Watanabe, Y, and Heistad, D.D.: Targeting Cerebral Arteries for Gene Therapy. Exp. Physiol.: Transl. Integration, 90:327-331, 2005.
38. Watanabe, Y., Faraci, F.M., and Heistad, D.D.: Activation of Rho-Associated Kinase During Augmented Contraction of the Basilar Artery to Serotonin After Subarachnoid Hemorrhage. Am. J. Physiol. Heart, 288:H2653-H2658, 2005.
39. Iida, S., Baumbach, G.L., Lavoie, J.L., Faraci, F.M. Sigmund, C.D., and Heistad, D.D.: Spontaneous Stroke in a Genetic Model of Hypertension in Mice. Stroke, 36:1253-1258, 2005.
40. Iida, S., Francis, J., Chu, Y., Weiss, R.M., Gunnett, C.A., Faraci, F.M., and Heistad, D.D.: Gene Transfer of ECSOD Improves Endothelial Function in Rats with Heart Failure. Am. J. Physiol.: Heart, 289:H525-532, 2005.
41. Gunnett, C.A., Lund, D.D., Faraci, F.M., and Heistad, D.D.: Vascular Interleukin-10 Protects Against LPS-Induced Vasomotor Function. Am. J. Physiol.: Heart, 289:H624-H630, 2005.
42. Gunnett, C.A., Lund, D.D., McDowell, A., Faraci, F.M., and Heistad, D.D.: Mechanisms of iNOS Mediated Vascular Dysfunction. Arterioscler. Thromb. Vasc. Biol., 25:1617-1622, 2005.
43. Chu, Y., Alwahdani, A., Iida, S., Lund, D.D., Faraci, F.M., and Heistad, D.D.: Vascular Effects of Human Extracellular SODR213G Variant. Circulation, 112:1047-1053, 2005.
44. Ohashi, M., Faraci, F.M., and Heistad, D.D.: Peroxynitrite Hyperpolarizes Smooth Muscle and Relaxes Internal Carotid Artery in Rabbit via ATP-Sensitive K+ Channels. Am. J. Physiol.: Heart, 289:H2244-H2250, 2005.
45. Sethi, S., Iida, S., Sigmund, C.D., and Heistad, D.D.: Renal Thrombotic Microangiopathy in a Genetic Model of Hypertension in Mice. Exp. Biol. Med., 231:196-203, 2006.
46. Heistad, D.D. Duff Lecture: Oxidative Stress and Vascular Disease. Arterioscler. Thromb. Vasc. Biol., 26:689-695, 2006.
47. Brown, K.A., Chu, Y., Lund, D.D., Heistad, D.D., and Faraci, F.M.: Gene Transfer of Extracellular Superoxide Dismutase Protects Against Vascular Dysfunction with Aging. Am. J. Physiol., 290:H2600-H2605, 2006.
48. Iadecola, C., Goldman, S.S., Harder, D.R., Heistad, D.D., Katusic, Z.S., Moskowitz, M.A., Simard, J.M., Sloan, M.A., Traystman, R.J., and Velletri, P.A. Recommendations of the National Heart, Lung, and Blood Institute Working Group on Cerebrovascular Biology and Disease. Stroke, 37:1578-1581, 2006.

Links of Interest

• Community of Science Profile
• Department of Pharmacology
• Graduate Program in Neuroscience

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