Department of Internal Medicine

Cardiovascular Medicine Faculty

Donald Heistad photo

Medical School:
University of Chicago

Residency:
University of Chicago

Fellowship:
The University of Iowa

Donald D. Heistad, M.D.
Zahn Professor of Cardiology (Internal Medicine and Pharmacology)

Dr. Heistad's clinical interests include general cardiology. His research interests focus on pathophysiology of aortic valve stenosis; cerebral circulation, and vascular biology of atherosclerosis, hypertension, and diabetes.

Honors, Awards, and Organizations

Links of Interest

Recent Publications (selected from 500)

Miller, JD. Weiss R M., Serrano KM., Castaneda, LE, Brooks RM., and Heistad DD.. Evidence for Active Regulation of Pro-osteogenic Signaling in Advanced Aortic Valve Disease. Arterioscler. Thromb. Vasc. Biol., (in press), 2010.

Wakisaka, Y., Chu, Y., Miller, J.D., Rosenberg, G.A., and Heistad D.D. Critical Role for CuZn-Superoxide Dismutase in Preventing Spontaneous Intracerebral Hemorrhage During Acute and Chronic Hypertension in Mice. Stroke, 41:790-797, 2010.

Miller, J.D., Peotta, V.A., Chu, Y., Weiss, R.M., Zimmerman, K., Brooks, R.M., and Heistad, D.D. MnSOD Protects Against COX1-mediated Endothelial Dysfunction in Chronic Heart Failure. Am. J. Physiol: Heart, 298:H1600-1607, 2010.

Wakisaka, Y., Chu, Y., Miller, J.D., Rosenberg, G.A., and Heistad, D.D.: Spontaneous Intracerebral Hemorrhage During Acute and Chronic Hypertension in Mice. J. Cereb. Blood Flow Metab., 30:56-69, 2010.

Berry, C.J., Miller, J.D., McGroary, K.A., Thedens, D.R., Young, S.G., Heistad, D.D., and Weiss, R.M.: Biventricular Adaptation to Volume Overload in Mice with Aortic Regurgitation. J Cardiovasc Magnetic Resonance, 11:27-32, 2009.

Peña -Silva, R.A., Miller, J.D., Chu, Y., and Heistad, D.D.: Serotonin Produces Monoamine Oxidase-dependent Oxidative Stress in Human Heart Valves. Am. J. Physiol.: Heart, 297:H1354-H1360, 2009.

Lund, D.D., Chu, Y., Miller, J.D., and Heistad, D.D.: Protective Effect of Extracelluar Superoxide Dismutase on Endothelial Function During Aging. Am. J. Physiol: Heart, 296:H1920-1925, 2009.

Miller, J.D., Weiss, R.M., Serrano, K.M., Brooks, R.M., Berry, C.J., Zimmerman, K., Young, S.G., and Heistad, D.D.: Lowering Plasma Cholesterol Halts Progression of Aortic Valve Disease in Mice. Circulation, 119:2693-2701, 2009.

Laviña, B., Gracia-Sancho, J., Rodriguez-Vilarrupla, A., Chu, Y., Heistad, D.D., Bosch, J., and Garcia-Pagán, J.C.: Superoxide Dismutase Gene Transfer Reduces Portal Pressure in CCI 4 Cirrhotic Rats with Portal Hypertension. Gut, 58:118-125, 2009.

Heistad, D.D.: Endothelial Function in the Time of the Giants: Paul M. Vanhoutte Lecture. J. Cardiovasc. Pharmacol., 52:385-392, 2008.

Heistad, D.D., Watanabe, Y., Chu, Y.: Gene Transfer After Subarachnoid Hemorrhage: A Tool and Potential Therapy. Acta Neurochir Suppl 104: V-VI, 2008.

Heistad, D.D., Wakisaka, Y., Miller, J., Chu, Y., Pena-Silva R. Novel Aspects of Oxidative Stress in Cardiovascular Diseases. Circ. J., 73:201-207, 2008.

Ai, L., Rouhanizadeh, M., Wu, J. C., Takabe, W., Yu, H., Alavi, M, Li, R., Chu, Y., Miller, J., Heistad, D., and Hsiai, T.: Oscillatory Shear Stress Influences Spatial Variations in Vascular MnSOD Expression and Nitrotyrosine Formation. Am. J. Physiol.: Cell Physiol., 294:C1576-1585, 2008.

Miller, J.D., Chu, Y., Brooks, R.M., Richenbacher, W.E., Pe~na-Silva, R., and Heistad, D.D. Dysregulation of Antioxidant Mechanisms Contributes to Increased Oxidative Stress in Calcific Aortic Valvular Stenosis in Humans. J. Amer. Coll. Cardiol., 52:843-850, 2008.

Wakisaka, Y., Miller, J.D., Chu, Y., Baumbach, G.L., Wilson, S., Faraci, F.M., Sigmund, C.D., and Heistad, D.D. Oxidative Stress Through Activation of NAD(P)H Oxidase in Hypertensive Mice with Spontaneous Intracranial Hemorrhage. J. Cereb. Blood Flow Metab., 28:1175-1185, 2008.

Lund, D.D., Brooks, R.M., Faraci, F.M., and Heistad, D.D. Role of Angiotensin II in Endothelial Dysfunction Induced by Lipopolysaccharide in Mice. Am. J. Physiol: Heart, 293:H3726-H3731, 2007.

Lund, D.D., Chu, Y., Brooks, R.M., Faraci, F.M., and Heistad, D.D. Effects of a Common Human Gene Variant of ECSOD on Endothelial Function After Endotoxin in Mice. J. Physiol. (London), 584.2:583-590, 2007.

Yu, Y., Zhang, Z-H., Wei, S-G., Chu, Y., Weiss, R.M., Heistad, D.D., and Felder, R.B. Central Gene Transfer of Interleukin-10 Reduces Hypothalamic Inflammation and Evidence of Heart Failure in Rats After Myocardial Infarction. Circ. Res., 101:304-312, 2007.

Hansson, G.K., and Heistad, D.D.:  Editorial: Two Views on Plaque Rupture. Arterioscler. Thromb. Vasc. Biol., 27:697, 2007.

Kitayama, J., Faraci, F.M., Lentz, S.R., and Heistad, D.D. Cerebral Vascular Dysfunction During Hypercholesterolemia. Stroke, 38:2136-2141, 2007.

Chu, Y., Miller, J.D., and Heistad, D.D. Gene Therapy for Stroke: 2006 Overview. Current Hypertens Rep., 9:19-24, 2007.

Tsimikas, S., Aikawa, M., Miller, F.J. Jr., Miller, E.R., Torzewski, M., Lentz, S.R., Bergmark, C., Heistad, D.D., Libby, P., Witztum, J.L. Concomitant Depletion of Oxidized Phospholipids from Atherosclerotic Lesions Following Dietary Lipid Lowering: A Potential Biomarker of Early Atherosclerosis Regression. Arterioscler. Thromb. Vasc. Biol., 27:175-181, 2007.

Heistad, D.D. Gene Therapy for Cardiovascular Disease,” 8th Intl Conference on Vascular Endothelium: Translating Discoveries into Public Health Practice, Centers for Disease Control and Prevention. Vasc. Pharmacol., 45: 331-333, 2006.

Weiss, R.M., Ohashi, M.; Miller, J.D., Young, S.G., and Heistad, D.D. Calcific Aortic Valve Stenosis in Old Hypercholesterolemic Mice. Circulation, 114:2065-2069, 2006.

Kitayama, J., Chu, Y., Faraci, F.M., and Heistad, D.D. Modulation of Dilator Responses of Cerebral Arterioles by Extracelluar Superoxide Dismutase. Stroke, 37:2802-2806, 2006.

Ohashi, M., Runge, M.S., Faraci, F.M., and Heistad, D.D. MnSOD Deficiency Increases Endothelial Dysfunction in apoE-Deficient Mice. Arterioscler. Thromb. Vasc. Biol., 26:2331-2336, 2006.

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