Department of Internal Medicine
Cardiovascular Medicine Faculty
Graduate School:
Molecular and Cellular Biology,
State University of New York, Buffalo
Fellowship:
Roswell Park Cancer Institute,
Buffalo, New York
Curt D. Sigmund, Ph.D.
Professor of Medicine and Molecular Physiology and Biophysics
Director, Center of Functional Genomics of Hypertension
Dr. Sigmund's research interests focus on mechanisms of blood pressure regulation by the renin-angiotensin system. He utilizes a combination of molecular biological and physiological approaches to the problem. Currently, Dr. Sigmund is interested in constructing transgenic animal models of hypertension and in examining the molecular biology of the human renin-angiotensin system in transgenic mice.
Honors, Awards, and Organizations
- American Association for the Advancement of Science
- American Heart Association
- Council on High Blood Pressure Research
- American Physiological Society
Recent Publications
- Cvetkovic, B., Keen, H.L., Zhang, X., Davis, D., Yang, B., and Sigmund, C.D.: Physiological Significance of Two Common Haplotypes of Human Angiotensinogen Using Gene Targeting in the Mouse. Physiological Genomics 11: 253-262, 2002.
- Liu, X., Huang, X., Sigmund, C.D.: Identification of A Nuclear Orphan Receptor (Ear2) As A Negative Regulator of Renin Gene Transcription. Circulation Research 92: 1033-1040, 2003.
- Morimoto, S., Cassell, M.D., and Sigmund, C.D. Glial- and neuronal-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference. J. Biol. Chem. 277:33235-33241, 2002.
- Ryan, M.J., Didion, S.P., Davis, D.R., Faraci, F.M., and Sigmund, C.D. Endothelial Dysfunction and Blood Pressure Variability in Selected Inbred Mouse Strains. Arteriosclerosis, Thrombosis, and Vascular Biology 22: 42-48, 2002.
- Morimoto, S., Cassell, M.D., and Sigmund, C.D. The Brain Renin-Angiotensin System in Transgenic Mice Carrying a Highly Regulated Human Renin Transgene. Circulation Research 90:80-86, 2002.
- Stec, D.E., Keen, H.L., and Sigmund, C.D. Lower Blood Pressure in Floxed Angiotensinogen Mice After Adenoviral Delivery of Cre-recombinase. Hypertension 39: 629-633, 2002.
- Lazartigues, E., Dunlay, S.M., Loihl, A.K., Sinnayah, P., Lang, J.A., Espelund, J.J., Sigmund, C.D., and Davisson, R.L. Brain-Selective Overexpression of Angiotensin (AT1) Receptors Causes Enhanced Cardiovascular Sensitivity in Transgenic Mice. Circulation Research 90:609-616, 2002.
- Nistala, R. and Sigmund, C.D. A Reliable and Efficient Method for Deleting Operational Sequences in PACs and BACs. Nucleic Acids Research 30: e41, 2002.
- Morimoto, S., Cassell, M.D., and Sigmund, C.D. Neuron-Specific Expression of Human Angiotensinogen in Brain Causes Increased Salt Appetite. Physiological Genomics 9: 113-120, 2002.
- Didion, S.P., Ryan, M.J., Baumbach, GL., Sigmund, C.D., and Faraci, F.M.: Superoxide Contributes to Vascular Dysfunction in Mice That Express Human Renin and Angiotensinogen. Am.J.Physiol. Heart and Circ 283: H1569-H1576, 2002.
- Baumbach, G.L, Sigmund, C.D., and Faraci, F.M.: Cerebral Arteriolar Structure in Mice Overexpressing Human Renin and Angiotensinogen. Hypertension 41:50-55, 2003.
Links of Interest