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Department of Internal Medicine

Cardiovascular Medicine Faculty


Christopher J. Benson, M.D.
Associate Professor

Dr. Benson's research interests include the study of ion channels involved in sensation. We have focused on a class of ion channels called Acid-sensing Ion Channels (ASICs), which play a role in responses to nociceptive, taste, and mechanical stimuli. We have discovered that ASICs are highly expressed in cardiac sensory neurons and we believe they are particularly important as pH sensors in the setting of myocardial ischemia. In addition, we are interested in how cardiac afferent activation might trigger deleterious neural reflexes in cardiac disease states. Our lab is also interested on the general physiology of ASIC channels, and has discovered several proteins and signaling pathways that modulate ASIC function. Our research methods utilize electrophysiology, whole animal recordings, molecular and cell biology, and protein biochemistry techniques.

Honors, Awards, and Organizations

  • Alpha Omega Alpha, 1990
  • Minnesota Medical Foundation Institutional Medical Student Research Award, 1990
  • American Heart Association Postdoctoral Fellowship Award, 1995
  • NIH K08 Mentored Clinical Scientist Development Award, 1999-2005
  • NIH R01, "Acid-Sensing Ion Channels in Cardiac Ischemia", 2004-active
  • Cardiovascular Fellowship Research Director, 2004-

Christopher Benson photo

Medical School:
University of Minnesota

Residency:
University of Minnesota

Fellowship:
Oregon Health Sciences University

Recent Publications

  1. Price, M.P., Thompson, R.J., Eshcol, J.O., Wemmie, J.A., and Benson, C.J.: Stomatin modulates gating of ASIC channels. J. Biol. Chem. 279(51):53886-53891, 2004.
  2. Hruska-Hageman, A.M., Benson, C.J., Leonard, A.S., Price, M.P., and Welsh, M.J.: PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+-gated current. J. Biol. Chem. 279(45):46962-46968, 2004.
  3. Benson, C.J., Xie, J., Wemmie, J.A., Price, M.P., Henss, J.M., Welsh, M.J., and Synder, P.M.: Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc. Natl. Acad. Sci. U.S.A, 99:2338-43, 2002.
  4. Click to view additional publications.

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