Department of Internal Medicine

Allergy-Immunology Faculty

Graduate School:
MBA, Tippie College of Business,
The University of Iowa

Medical School:
Temple University

Residency:
Indiana University
Kansas University

Fellowship:
Harvard University

Special Training:
National Heart and Lung Institute,
NIH Scripps Clinic and
Research Foundation,
Visiting Investigator, 1986

John M. Weiler, M.D.
Professor Emeritus

Dr. Weiler's research interests center on the role of complement in a variety of biological situations. His molecular biology laboratory studies: C1 inhibitor; heparin interactions with Cl inhibitor; heparin and heparin sulfate interactions with a variety of other heparin binding products. In addition, he studies a variety of complement deficiency states.

Honors, Awards, and Organizations

• American Academy of Allergy, Asthma and Immunology, Fellow, Web Editor
• American Society for Biochemistry and Molecular Biology, Member
• American Association of Immunologists, Member
• American Board of Internal Medicine, Board of Diagnostic Laboratory Immunology, and Board of Allergy and Immunology, Certification
• American College of Physicians, Fellow
• NIH Research Development Career Awardee
• Veterans Administration: Clinical Investigator Career Awardee; Merit Review Board for Immunology, 1988-91 (Chairman, 1991); Program Specialist in Immunology, 1985-88; Research Associate Career Awardee
• Central Society for clinical Research, Member
• American College of Rheumatology, Fellow
• Annals of Allergy, Asthma and Immunology, Section Editor
• American Journal of Medicine and Sports, Editorial Board

Representative Publications

1. Weiler, J.M., Quinn, S.A., Woodworth, G.G., Brown, D.D., Layton, T.A., Maves, K.K. Does heparin prophylaxis prevent exacerbations of hereditary angioedema? J Allergy Clin Immunol 2002 Jun;109(6 Pt 1):995-1000
2. Wolff, M.W., Zhang, F., Roberg, J.J., Caldwell, E.E., Kaul, P.R., Serrahn, J.N., Murhammer, D.W.,  Linhardt, R.J., Weiler, J.M. Expression of C1 esterase inhibitor by the baculovirus expression vector system: preparation, purification, and characterization. Protein Expr Purif 2001 Aug;22(3):414-21
3. Edens, R.E., LeBrun, L.A., Linhardt, R.J., Kaul, P.R. and Weiler, J.M.:  Certain High Molecular Weight Heparin Chains have High Affinity for Vitronectin. Arch Biochem Biophys, 391 (2):278-285, 2001.
4. Bowen, B., Hawk, J.J., Sibunka, S., Hovick, S. and Weiler, J.M.: A Review of  the Reported Defects in the Human C1 Esterase Inhibitor Gene Producing Hereditary Angioedema including Four New Mutations. Clin. Immunol., 98 (2):157-163, 2001 .
5. Weiler JM, Bloomfield JR, Woodworth GG, Grant AR, Layton TA, Brown TL, McKenzie DR, Baker TW, Watson GS. Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator. Ann Intern Med. 2000 Mar 7;132(5):354-63.
6. Booth, B.A., Boes, M., Dake, B.L., Caldwell, E.E.O., Weiler, J.M., Bar, R.S.: Effect of IGFBP-Derived Peptides on Incorporation of (35) SO(4) into Proteoglycans.   Growth Horm. IGF Res., 10 (4):224-229, 2000.
7. Fromm, J.R., Hileman, R.E., Caldwell, E.E.O., Weiler, J.M., and Linhardt, R.J.: Pattern and Spacing of Basic Amino Acids in Heparin Binding Sites. Archives of Biochemistry and Biophysics 343:92-100, 1997.
8. Fromm, J.R., Hileman, R.E., Weiler, J.M., and Linhardt, R.J.: Interaction of Fibroblast Growth Factor-1 and Related Peptides with Heparin Sulfate and Its Oligosaccharides. Archives of Biochemistry and Biophysics 346:001-011, 1997.
9. Weiler, J.M., Layton, T., and Peter, M. Asthma in United States Olympic Athletes who Participated in the 1996 Summer Games. (In Press)
10. Caldwell, E.E.O., Nadkarni, V.D., Fromm, J.R., Linhardt, R.J., and Weiler, J.M.: Importance of specific amino acids in protein binding sites for Heparin and Heparan sulfate. Int. J. Biochem. Cell Biol ., 28:203-216, 1996.
11. Meltzer, E.O., Weiler, J.M., and Widlitz, M.D.: Comparative outdoor study of the efficacy, onset and duration of action, and safety of Cetirizine, Loratadine, and Placebo for seasonal allergic rhinitis. J. Allergy Clin. Immunol., 97:617-626, 1996 .
12. Weiler, J.M.: Exercise-induced asthma: A practical guide to definitions, diagnosis, prevalence, and treatment. Allergy and Asthma Proc., 17:315-325, 1996.

Recent Books and/or Chapters

1. Whaley, K., Loos, M., and Weiler, J.M., eds.: Complement in Health and Disease, 2nd Edition, Kluwer Academic Publishers, The Netherlands, 1993.
2. Edens, R.E., Linhardt, R.J., and Weiler, J.M.: Heparin is Not Just an Anticoagulant Anymore: Six and One-Half Decades of Studies on the Ability of Heparin to Regulate Complement Activity. In: Complement Profiles, J.M. Cruise and R.E. Lewis, Jr., eds. Karger, Basel, 1:96-120, 1993.
3. Weiler, J.M., ed.. Allergic and Respiratory Disease in Sports Medicine, Marcel Dekker, New York, 1997
4. Baker, W.H. and Weiler, J.M.. The Role of Exercise Training and Conditioning in Patients with Asthma. In: Allergic and Respiratory Disease in Sports Medicine, Marcel Dekker, New York, 179, 1997.

Links of Interest

• Community of Science Profile

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