Department of Internal Medicine
Nephrology Faculty
Medical School:
University of Illinois
Residency:
The University of Iowa
Chief Residency:
The University of Iowa, 2001-02
Kevin Glenn, M.D.
Assistant Professor
Dr. Glenn's research interests include the molecular biology of aging, specifically studying the accumulation of misfolded proteins in normal aging and determining whether this is a marker or a cause of aging. His clinical interest lies in the area of hospitalist medicine.
Recent Grants:
- VA –Career Development Award-2, “Hepatic protein degradation in A1AT deficiency and senescence.”
- Ellison Medical Foundation New Scholars in Aging Grant “ Do Misfolded Proteins Accumulate with Age or Senescence?”
Recent Publications
- A. Mallinger, H. M. Wen, G. M. Dankle, K. A. Glenn, Using a Ubiquitin Ligase as an Unfolded Protein Sensor. Biochemical and Biophysical Research Communications,(2011) ePub: 29 Dec 2011: DOI: 10.1016/j.bbrc.2011.12.109
- Mallinger, A.J., Wen, H.M., and Glenn, K.A.: Using a ubiquitin ligase as an unfolded protein sensor. 2010 Under review.
- Gordon KL, Glenn KA, and Gonzalez-Alegre P.: Exploring the Influence of TorsinA Expression on Protein Quality Control. Neurochem Res. 2010 Dec 16. [Epub ahead of print].
- Wen, H., Kim, N., Mallinger, A., Fuentes, E.J., Gonzalez-Alegre, P., and Glenn, K.A.: The F box protein FBG1 Sequesters APC2 and causes S-phase arrest. Cell Cycle. 2010 Nov 15;9(22). [Epub ahead of print].
- Glenn, K.A., Nelson, R.F., Wen, H.M., Mallinger, A.J., Paulson, H.L.: Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. J. of Biol. Chem. 283: 12717-12729, 2008.
- Nelson, R.F., Glenn, K.A., Zhang, Y., Wen, H., Knutson, T., Gouvion, C., Robinson, B., Zhou, Z., Yang, B., Smith, R.J.H., Paulson, H.: Selective Cochlear Degeneration in Mice Lacking the F-box Protein, Fbx2, a Glycoprotein-Specific Ubiquitin Ligase Subunit. J. Neuroscience 27: 5163-71, 2007.
- Nelson, R. F., Glenn, K. A., Miller, V. M., Wen, H., and Paulson, H.L. A Novel Route for F-box Protein-mediated Ubiquitination Links CHIP to Glycoprotein Quality Control. J. Biol. Chem. 281, 20242-20251, 2006.
- Zhang, C.C., Glenn, K.A., Kuntz, M.A., and Shapiro, D.J. High level expression of full-length estrogen receptor in Escherichia coli is facilitated by the uncoupler of oxidative phosphorylation, CCCP. Journal of Steroid Biochemistry and Molecular Biology 74, 169-178, 2000.
- Chusacultanachai, S., Glenn, K. A., Rodriguez, A. O., Read, E. K., Gardner, J. F., Katzenellenbogen, B. S., and Shapiro, D. J. Analysis of Estrogen Response Element Binding by Genetically Selected Steroid Receptor DNA Binding Domain Mutants Exhibiting Altered Specificity and Enhanced Affinity. J. Biol. Chem. 274, 23591-23598, 1999.
- Mattick, S., Glenn, K., de Haan, G., and Shapiro, D.: Analysis of Ligand Dependence and Hormone Response Element Synergy in Transcription by Estrogen Receptor. Journal of Steroid Biochemistry and Molecular Biology, 60 (5-6):285-294, 1997.
- Lee, Y.P., Adimoolam, S., Liu, M., Subbaiah, P.V., Glenn, K., and Jonas, A.: Analysis of Human Lecithin-Cholesterol Acetyl Transferase Activity by Carboxyl-Terminal Truncation. Biochem Biophys Acta 1344 (3):250-261, 1997.